7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide

7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.

Also Known As:

7,8-BaP-9,10-Diol Epoxide; Anti-BaPDE; BPDE; Benzo(a)pyrene-7,8-diol 9,10-Epoxide; Anti BaPDE; 7,8-Dihydroxy-9,10-Epoxy-7,8,9,10-Tetrahydrobenzo(a)pyrene; Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide; Benzo(10,11)chryseno(3,4-b)oxirene-7,8-diol, 7,8,8a,9a-tetrahydro-

Networked: 193 relevant articles (9 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wu, Xifeng: 12 articles (09/2008 - 01/2002)
2.	Spitz, Margaret R: 12 articles (06/2008 - 01/2002)
3.	Zhang, Huidong: 9 articles (06/2022 - 02/2018)
4.	Wei, Qingyi: 8 articles (01/2012 - 10/2003)
5.	Wang, Li-E: 7 articles (01/2012 - 10/2003)
6.	Huang, Wenxin: 6 articles (06/2022 - 01/2021)
7.	Tian, Peng: 6 articles (01/2022 - 01/2021)
8.	Dai, Mengyuan: 5 articles (06/2022 - 01/2021)
9.	Liang, Tingting: 5 articles (01/2022 - 01/2021)
10.	Mi, Chenyang: 5 articles (01/2022 - 01/2021)

Related Diseases

1.	Neoplasms (Cancer) 09/16/1997 - "The results of the present study suggest that differences in the ability of OSCs to modulate GST activity toward anti-BPDE may, at least in part, account for their differential chemopreventive efficacy against BP-induced cancer in mice." 03/01/2018 - "In conclusion, this study demonstrates a profound role of PARylation in BPDE-induced genotoxic stress response with significant functional consequences and potential relevance with regard to B[a]P-induced cancer risks." 01/01/2014 - "As expected, BPDE caused significant DNA fragmentation in tumor compared to negative control tissues. " 10/01/2007 - "Chronic exposure of wild-type (Cdc25B+/+) MEFs to anti-BPDE (0.1 micromol/L) caused neoplastic transformation characterized by colony formation in culture and tumor production in nude mice. " 09/01/2003 - "The volume of tumor in groups treated with both CHL and BPDE (0.43 +/- 0.13) cm(2), (0.22 +/- 0.04) cm(2) and (0.10 +/- 0.06) cm(3) was significantly smaller (P < 0.05) and dose-dependent, as compared with that in the group treated with BPDE alone (1.71 +/- 0.37) cm(3). "
2.	Carcinogenesis 02/03/2010 - "In conclusion, this whole-genome time-course study has identified a dynamically regulated transcriptional signature after low-dose BPDE exposure, which may help to understand the complex mechanisms of mutagenesis and carcinogenesis induced by BPDE." 02/01/2009 - "These results may help to explain epithelial cell transformation following exposure to anti-BPDE, and suggest an oncogenic role for HER2/neu in anti-BPDE-induced carcinogenesis." 11/01/2021 - "In the present study, a malignant transformation model of human bronchial epithelial cells induced by benzo (a) pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) was established to observe the regulatory patterns between TP53 and PPP1R13L during carcinogenesis. " 01/01/2021 - "This study found that EGR1 was significantly downregulated during human bronchial epithelial cell transformation and mice lung carcinogenesis upon exposure to B[a]P and its active form BPDE, respectively. " 09/10/2011 - "In our study, we used the malignant transformation of human bronchial epithelial cells (16HBE-T) induced by anti-BPDE to explore the mechanisms of human lung carcinogenesis. "
3.	Lung Neoplasms (Lung Cancer) 07/15/2007 - "In conclusion, the present study points towards an important role of p53 in regulation of cellular responses to BPDE in human lung cancer cells." 01/01/2021 - "We identified 15 CpGs associated with BPDE-Alb adducts (P-meta < 1.0 × 10-5), among which the methylation levels at five loci (cg06245338, cg24256211, cg15107887, cg02211741, and cg04354393 annotated to UBE2O, SAMD4A, ACBD6, DGKZ, and SLFN13, respectively) mediated a separate 38.5%, 29.2%, 41.5%, 47.7%, 56.5%, and a joint 58.2% of the association between BPDE-Alb adducts and lung cancer risk. " 07/15/2007 - "The H460 human lung cancer cell line (wild-type p53) was relatively more sensitive to BPDE-mediated growth inhibition and enrichment of sub-diploid apoptotic fraction compared with H1299 cells. " 07/01/2004 - "The predicted BPDE spectrum strongly resembles the G-->T mutation spectrum compiled from known lung cancer mutation data from smokers and further supports evidence that BPDE contributes to the overall smoking-related mutation distribution in lung cancer. " 10/01/2003 - "After exposing the cells to 4 microM BPDE for 5 h, we observed a significantly lower AC in lung cancer patients (155.2+/-143.9%) than in the controls (216.6+/-184.6%) (P<0.05). "
4.	Spontaneous Abortion (Miscarriage) 01/01/2023 - "These findings provided new insights into BaP/BPDE-induced trophoblast cell pyroptosis and miscarriage and might be helpful for further assessment of the toxicological effects of BaP/BPDE on the female reproduction." 10/01/2023 - "Overall, this study uncovered the crosstalk among BaP/BPDE exposure, ferroptosis, angiogenesis, and miscarriage, discovering novel toxicological effects of BaP/BPDE on human reproductive health. " 10/01/2023 - "We found that BaP/BPDE exposure caused ferroptosis and then directly suppressed angiogenesis and eventually induced miscarriage. " 10/01/2023 - "However, till now, BaP/BPDE exposure, ferroptosis, defective angiogenesis, and miscarriage have never been correlated; and their regulatory mechanisms have been rarely explored. " 10/01/2023 - "BaP/BPDE suppressed endothelial cell angiogenesis to induce miscarriage by promoting MARCHF1/GPX4-mediated ferroptosis."
5.	Xeroderma Pigmentosum (Kaposi's Disease) 01/01/1986 - "Xeroderma pigmentosum fibroblasts, complementation group A (XP12BE) had 20-25% more ESS at each dose than the BPDE-treated normal (HSBP) cells. " 05/15/1991 - "We have now determined the kinds and location of independent mutations induced by BPDE in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene of synchronized repair-deficient xeroderma pigmentosum cells (XP12BE, complementation group A), treated at S or in G1. " 06/01/1982 - "The cytotoxic and mutagenic effect of (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti BPDE) in normally excising diploid human cells treated just prior to onset of S was compared with that of cells allowed approximately 16 h for excision repair before onset of S and with that observed in excision-deficient xeroderma pigmentosum (XP12BE) cells. " 12/01/1987 - "Results of the studies in diploid human cells indicated that when compared on the basis of equal numbers of DNA adducts, BPDE is more effective than 1-NOP in inducing mutations in DNA repair-proficient cells, but when compared in repair-deficient xeroderma pigmentosum human cells that do not remove such adducts from their DNA, the frequency of mutants induced per adduct is equal. " 01/01/2002 - "First, we treated apparently normal and xeroderma pigmentosum lymphoblastoid cell lines with various doses of benzo(a)pyrene diol epoxide (BPDE) and harvested cells at different time points. "

Related Drugs and Biologics

1.	Benzo(a)pyrene
2.	Carcinogens
3.	DNA Adducts
4.	DNA (Deoxyribonucleic Acid)
5.	Glutathione (Reduced Glutathione)
6.	diallyl trisulfide
7.	allyl sulfide
8.	dipropyl sulfide
9.	amsonic acid (DAS)
10.	Transferases

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Ligation
4.	Lasers (Laser)
5.	Hepatectomy