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5,8,11,14-Eicosatetraynoic Acid (5,8,11,14 Eicosatetraynoic Acid)

A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).
Also Known As:
5,8,11,14 Eicosatetraynoic Acid; Ro 3-1428; Ro 3 1428; Ro 31428; ETYA; 5,8,11,14-Eicosatetraynoic acid
Networked: 37 relevant articles (5 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Woo, Joo Hong: 1 article (01/2012)
2. Kim, Hyunmi: 1 article (01/2012)
3. Lee, Jee Hoon: 1 article (01/2012)
4. Jou, Ilo: 1 article (01/2012)
5. Joe, Eun-hye: 1 article (01/2012)
6. Lee, Crystal J J: 1 article (07/2011)
7. Gonçalves, Luisa L: 1 article (07/2011)
8. Wells, Peter G: 1 article (07/2011)
9. Saensuk, Theeranuch: 1 article (11/2010)
10. Monthanapisut, Paopanga: 1 article (11/2010)

Related Diseases

1. Pulmonary Edema
2. Neoplasms (Cancer)
06/01/1990 - "The consequences of incubating human cancer cells with ETYA, a competitive analogue of arachidonic acid, and the reported responses of cells cultured with polyunsaturated fatty acids indicate that polyunsaturated fatty acid analogues or their modified congeners could represent potential cytotoxic anticancer agents. "
03/01/1986 - "Nordihydroguaiaretic acid (NDGA), quercetin, eicosatetraynoic acid (ETYA), phenidone, and esculetin, agents known to inhibit cellular lipoxygenase (LO) activity, also inhibit human natural killer cell-mediated cytotoxicity (NK-CMC) of K562 tumor target cells (TC) in a dose-dependent fashion. "
07/01/1986 - "Rat splenic natural killer (NK) cell activity against 51Cr-labeled YAC-1 or TMT-081 tumor cells can be augmented by culturing at 37 degrees C for 18 hr. Inhibitors of the lipoxygenase pathway of arachidonic acid metabolism, NDGA, alpha-phenanthroline, quercetin, ETYA, BW755C, esculetin, and timegadine, inhibited this NK activation and also inhibited NK cytotoxicity when added directly to the NK assay. "
11/01/2010 - "In this study we investigate effects of sulindac (the non-selective COX inhibitor), aspirin (the irreversible, preferential COX-1 inhibitor), NS-398 (the selective COX-2 inhibitor), NDGA (nordihydroguaiaretic acid, the selective LOX inhibitor) and ETYA (5,8,11,14-eicosatetraynoic acid, the COX and LOX inhibitor) on cell viability, MMP-2 and MMP-9 activities, and in vitro invasion of cancer cells derived from primary and metastatic head and neck, and colon cancers. "
07/01/1985 - "Inhibitors of various parts of the arachidonic acid cascade were found to affect the TPA-induced CL response in a manner that corresponds to their effects in vivo tumor promotion experiments: agents which are predominantly lipoxygenase inhibitors, i.e., nordihydroguaiaretic acid, benoxaprofen, or agents which are effective against both lipoxygenase or cyclooxygenase, i.e., 5,8,11,14-eicosatetraynoic acid and phenidone, are effective in diminishing the CL response. "
3. Weight Gain
4. Fever (Fevers)
5. Asthma (Bronchial Asthma)

Related Drugs and Biologics

1. 5,8,11,14-Eicosatetraynoic Acid (5,8,11,14 Eicosatetraynoic Acid)
2. Arachidonic Acid (Vitamin F)
3. Acids
4. Lipoxygenase (Lipoxygenase-1)
5. Nordihydroguaiaretic Acid (Masoprocol)
6. Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
7. Lipoxygenase Inhibitors
8. Phosgene
9. Indomethacin (Indometacin)
10. Prostaglandins