5,7-Dihydroxytryptamine (5,7 Dihydroxytryptamine)

Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.

Also Known As:

5,7 Dihydroxytryptamine; 3-(2-Aminoethyl)-1H-indole-5,7-diol; 5,7-Dihydroxytryptamine Creatine Sulfate; 5,7 Dihydroxytryptamine Creatine Sulfate; Creatine Sulfate, 5,7-Dihydroxytryptamine; Sulfate, 5,7-Dihydroxytryptamine Creatine; 1H-Indole-5,7-diol, 3-(2-aminoethyl)-

Networked: 86 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Tryptamines: 1679
        Dihydroxytryptamines
        5,7-Dihydroxytryptamine: 86
        5-hydroxytryptamine-4,7-dione
        6,6'-bis(5-hydroxytryptamine-4,7-dione)

Experts

1.	Bromek, Ewa: 2 articles (01/2019 - 01/2016)
2.	Daniel, Władysława A: 2 articles (01/2019 - 01/2016)
3.	Haduch, Anna: 2 articles (01/2019 - 01/2016)
4.	Rysz, Marta: 2 articles (01/2019 - 01/2016)
5.	Huang, Li: 2 articles (04/2011 - 11/2010)
6.	Lei, Jing: 2 articles (04/2011 - 11/2010)
7.	Sui, Mei-Yu: 2 articles (04/2011 - 11/2010)
8.	Tan, Yong-Xiang: 2 articles (04/2011 - 11/2010)
9.	You, Hao-Jun: 2 articles (04/2011 - 11/2010)
10.	Clark, J David: 1 article (12/2019)

Related Diseases

1.	Shock 10/01/2004 - "In this study, we recorded from serotonergic neurons throughout the CNS, which were prelabeled with 5,7-dihydroxytryptamine, during an in vitro analog of sensitization training, tail-nerve shock. " 01/01/1986 - "9-16 days after injection of 5,7-dihydroxytryptamine which elicits degeneration of serotonergic nerve cell terminals, pairing of food and electrical shock had no effect on responses of injected animals to food, while definite food-aversive reactions were observed in control animals. " 11/01/2000 - "5-HT depletion by intracerebroventricular 5,7-dihydroxytryptamine (5,7-DHT)-induced disinhibitory behavior in a shock-induced behavioral inhibition model (punished conflict model) 14 days after operation. " 01/01/1981 - "Using a 15-s intershock interval, an increase in shock-induced fighting was observed following intraventricular 96 microgram 5,7-dihydroxytryptamine (5,7-DHT) and 90 microgram 6-hydroxydopa (6-OHdopa). " 01/01/1981 - "Facilitation of shock-induced fighting following intraventricular 5,7-dihydroxytryptamine and 6-hydroxydopa."
2.	Hypothermia 03/01/1993 - "These data suggest, by analogy, that postsynaptic 5-HT1A receptors mediate hypothermia, an interpretation supported by the observation that destruction of central 5-HT neurons with 5,7-dihydroxytryptamine failed to reduce 8-OH-DPAT-induced hypothermia (DIH). " 10/01/1979 - "The effects of 5,7-dihydroxytryptamine and L-tryptophan treatment on ethanol tolerance in the rat, as measured by the moving-belt test of motor impairment and by hypothermia, were examined in separate studies. " 10/01/1979 - "5,7-Dihydroxytryptamine and L-tryptophan treatment did not alter either the motor impairment or hypothermia produced by the initial dose of ethanol. "
3.	AIDS-Related Complex (ARC) 01/01/2016 - "Male rats received bilateral injections of the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) into the PVN or ARC. " 01/01/2019 - "Our recent study carried out after local injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine into the arcuate nucleus (ARC) of the hypothalamus suggested a positive influence of the serotonergic innervation of the ARC on growth hormone (GH) secretion and GH-dependent expression of cytochrome P450. "
4.	Cough 08/24/1988 - "The present study sought to determine whether rats, treated neonatally with 5,7-dihydroxytryptamine (5,7-DHT), have an increased sensitivity to the respiratory and cough-depressant effects induced by dihydrocodeine. "
5.	Seizures (Absence Seizure) 01/01/1996 - "Effect of 5,7-dihydroxytryptamine on audiogenic seizures in genetically epilepsy-prone rats." 03/28/1996 - "Neither intranigral fluoxetine nor 5,7-dihydroxytryptamine alter audiogenic seizures in genetically epilepsy-prone rats." 01/01/1996 - "To further assess the role of 5-HT in the modulation of audiogenic seizures (AGS) in the Genetically Epilepsy-Prone Rat (GEPR), changes in AGS severity after widespread chronic depletion of brain 5-HT by intracerebroventricular administration of 5,7-dihydroxytryptamine (5,7-DHT) were examined in moderate seizure GEPRs (GEPR-3s). " 03/01/1983 - "5,7-Dihydroxytryptamine (5,7-DHT) injections which caused selective depletion of serotonin in the forebrain enhanced the seizures caused by pentylenetetrazol (PTZ 90 mg/kg s.c.) in rats. " 07/01/1976 - "A myoclonic syndrome consisting of tremor, myoclonus, and seizures was produced following the systemic administration of 5-hydroxytryptophan to adult rats previously given intracisternal injections of 5,7-dihydroxytryptamine and systemic desmethylimipramine, but not in their controls. "

Related Drugs and Biologics

1.	Neurotoxins
2.	Ethanol (Ethyl Alcohol)
3.	Tryptophan (L-Tryptophan)
4.	Growth Hormone (Somatotropin)
5.	Cytochrome P-450 Enzyme System (Cytochrome P450)
6.	dihydrocodeine
7.	Serotonin (5 Hydroxytryptamine)
8.	Oxidopamine (6 Hydroxydopamine)
9.	Fenclonine (p-Chlorophenylalanine)
10.	5-Hydroxytryptophan (5 Hydroxytryptophan)

Related Therapies and Procedures

1.	Injections
2.	Intraventricular Injections
3.	Spinal Injections
4.	Intravitreal Injections
5.	Intraperitoneal Injections