4-Hydroxycoumarins

Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.

Also Known As:

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Casu, Laura: 1 article (09/2012)
2.	Chicca, Andrea: 1 article (09/2012)
3.	Delogu, Giovanna: 1 article (09/2012)
4.	Gertsch, Jürg: 1 article (09/2012)
5.	Santana, Lourdes: 1 article (09/2012)
6.	Serra, Silvia: 1 article (09/2012)
7.	Uriarte, Eugenio: 1 article (09/2012)
8.	Vázquez-Rodríguez, Saleta: 1 article (09/2012)
9.	Gebauer, Markus: 1 article (03/2007)

Related Diseases

1.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 09/15/2012 - "In the present communication we report the synthesis of a series of 12 diversely substituted 4-oxycoumarin derivatives including methoxy substituted 4-hydroxycoumarins, methyl, methoxy or unsubstituted 3-aryl-4-hydroxycoumarins and 4-benzyloxycoumarins and their anti-proliferative effects on breast adenocarcinoma cells (MCF-7), human promyelocytic leukemia cells (HL-60), human histiocytic lymphoma cells (U937) and mouse neuroblastoma cells (Neuro2a). "
2.	Thrombosis (Thrombus) 03/15/2007 - "Yet little detail is known about the molecular interactions between 4-hydroxycoumarins with vitamin K epoxide reductase (VKER), inhibition of which produces a deficiency of vitamin K and consequently a deficiency of vitamin K-dependent proteins involved in thrombus formation. "
3.	Neuroblastoma 09/15/2012 - "In the present communication we report the synthesis of a series of 12 diversely substituted 4-oxycoumarin derivatives including methoxy substituted 4-hydroxycoumarins, methyl, methoxy or unsubstituted 3-aryl-4-hydroxycoumarins and 4-benzyloxycoumarins and their anti-proliferative effects on breast adenocarcinoma cells (MCF-7), human promyelocytic leukemia cells (HL-60), human histiocytic lymphoma cells (U937) and mouse neuroblastoma cells (Neuro2a). "
4.	Leukemia 09/15/2012 - "In the present communication we report the synthesis of a series of 12 diversely substituted 4-oxycoumarin derivatives including methoxy substituted 4-hydroxycoumarins, methyl, methoxy or unsubstituted 3-aryl-4-hydroxycoumarins and 4-benzyloxycoumarins and their anti-proliferative effects on breast adenocarcinoma cells (MCF-7), human promyelocytic leukemia cells (HL-60), human histiocytic lymphoma cells (U937) and mouse neuroblastoma cells (Neuro2a). "
5.	Adenocarcinoma 09/15/2012 - "In the present communication we report the synthesis of a series of 12 diversely substituted 4-oxycoumarin derivatives including methoxy substituted 4-hydroxycoumarins, methyl, methoxy or unsubstituted 3-aryl-4-hydroxycoumarins and 4-benzyloxycoumarins and their anti-proliferative effects on breast adenocarcinoma cells (MCF-7), human promyelocytic leukemia cells (HL-60), human histiocytic lymphoma cells (U937) and mouse neuroblastoma cells (Neuro2a). "

Related Drugs and Biologics

1.	Vitamin K Epoxide Reductases
2.	Vitamin K
3.	Proteins (Proteins, Gene)