|1.||Snead, O Carter: 3 articles (05/2009 - 03/2006)|
|2.||Maher, Timothy J: 2 articles (01/2013 - 08/2006)|
|3.||Sadeghnia, Hamid R: 2 articles (05/2009 - 01/2008)|
|4.||Cortez, Miguel A: 2 articles (05/2009 - 01/2008)|
|5.||Nihira, Takuya: 2 articles (11/2008 - 09/2004)|
|6.||Kim, Joon: 2 articles (03/2008 - 08/2007)|
|7.||Ryu, Myung-Jeom: 2 articles (03/2008 - 08/2007)|
|8.||Lee, Cheolju: 2 articles (03/2008 - 08/2007)|
|9.||Yu, Myeong-Hee: 2 articles (03/2008 - 08/2007)|
|10.||Shin, Hee-Sup: 2 articles (03/2008 - 08/2007)|
12/03/2008 - "To induce non-convulsive seizures, animals (n = 6) received a single injection of gamma-butyrolactone (GBL, 100 mg/kg i.p.). "
07/01/1988 - "This potentiation of GHB seizure was observed when these compounds were given either before administration of gamma-butyrolactone (GBL), the prodrug of GHB, or at the onset of GHB-induced seizure. "
10/01/1986 - "alpha-Ethyl-alpha-methylthiolo-gamma-butyrolactone showed an increase in potency over the congeneric alpha-ethyl-alpha-methyl-gamma-butyrolactone and, additionally, was effective against maximal electroshock seizures. "
09/01/1994 - "This paper describes the synthesis of alpha-(dimethylaminoethyl)-gamma, gamma-diphenyl-gamma-butyrolactone 4. The study of convulsions induced, on mice, by this compound could show the existence of antiGABAergic and cholinergic action components, but, unlike the homologous alpha- (dialkylaminomethil)-gamma-butyrolactones (with one -CH2- less on the aminoalkyl chain), no antiglycinergic component was detected. "
05/01/2010 - "gamma-butyrolactone (GBL) and 4-aminopyridine (4-AP) were applied to induce absence and tonic-clonic seizures, respectively. "
|2.||Absence Epilepsy (Absence Seizure)
08/01/2007 - "To better understand the molecular mechanism related to the disease progress at protein level, we performed proteomic studies using the thalamus of mice for which absence seizure was induced by gamma-butyrolactone (GBL). "
10/01/2004 - "Adult male marmoset monkeys (Callithrix jacchus) were treated with gamma-butyrolactone (GBL) to induce prolonged absence seizures, and the resulting spike-wave discharges (SWDs) were analyzed to determine the similarity to the 3-Hz SWDs that characterize the disorder. "
09/01/2003 - "BOLD imaging was performed before, during, and after absence seizure induction by using gamma-butyrolactone (GBL; 200 mg/kg, intraperitoneal). "
04/06/2001 - "The prodrug of (GHB), gamma-butyrolactone (GBL) was given systemically to induce the absence seizures. "
01/01/1996 - "We examined the involvement of the GABAB receptor and the coordinated induction of nuclear transcriptional factors in experimental generalized absence seizures induced by gamma-butyrolactone (GBL) in mice. "
01/01/2011 - "[Acute gamma-butyrolactone poisoning with withdrawal syndrome]."
01/01/2005 - "The clinical features in this case resemble those of poisoning due to gamma butyrolactone, the principal component of this nail polish remover. "
05/01/2000 - "Revivarant (gamma-butyrolactone) poisoning."
08/01/1997 - "We report here 2 cases of gamma butyrolactone poisoning with a nail polish remover labelled "acetone-free". "
08/01/1997 - "Gamma butyrolactone poisoning and its similarities to gamma hydroxybutyric acid: two case reports."
01/01/2001 - "In this study, we use SAR approaches in an attempt to elucidate the action of gamma-butyrolactone (GBL), an illicit drug and a dietary supplement, that can cause coma and deaths in humans while exhibiting low systemic toxicity towards rodents. "
10/01/2004 - "Recreational abuse or overdose of GHB (or its precursors gamma-butyrolactone or 1,4-butanediol) results in dose-dependent central nervous system (CNS) effects (respiratory depression, unconsciousness, coma, and death) as well as tolerance and withdrawal. "
01/01/2001 - "We report the case of a 44-year-old man who suffered coma and life-threatening respiratory depression following an accidental overdose of the GHB prodrug, gamma-butyrolactone (GBL), contained in a "health drink". "
10/03/2003 - "Gamma-hydroxybutyrate (GHB) and its lactone, gamma-butyrolactone (GBL) have been previously shown to produce a protective effect in animal models of cerebral ischaemia/hypoxia, as well as in human conditions of head injury-induced coma. "
|1.||Sodium Oxybate (gamma Hydroxybutyrate)
|2.||gamma-Aminobutyric Acid (GABA)
|8.||Anticonvulsants (Antiepileptic Drugs)
|10.||DNA (Deoxyribonucleic Acid)