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3,4-Dihydroxyphenylacetic Acid

A deaminated metabolite of LEVODOPA.
Also Known As:
3,4-Dihydroxyphenylacetic Acid, Monosodium Salt; 3,4 Dihydroxyphenylacetic Acid; DOPAC; Homoprotocatechuic Acid; Benzeneacetic acid, 3,4-dihydroxy-
Networked: 356 relevant articles (9 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Iuvone, P Michael: 5 articles (01/2022 - 01/2013)
2. Laranjinha, João: 5 articles (01/2021 - 08/2005)
3. Nunes, Carla: 5 articles (01/2021 - 08/2005)
4. Goldstein, David S: 4 articles (01/2018 - 08/2009)
5. Pardue, Machelle T: 3 articles (01/2022 - 01/2013)
6. Jamwal, Sumit: 3 articles (04/2017 - 08/2015)
7. Kumar, Puneet: 3 articles (04/2017 - 08/2015)
8. Almeida, Leonor: 3 articles (09/2011 - 08/2005)
9. Stone, Richard A: 2 articles (01/2022 - 01/2016)
10. Li, Kai: 2 articles (11/2021 - 07/2020)

Related Diseases

1. Parkinson Disease (Parkinson's Disease)
2. Type 2 Diabetes Mellitus (MODY)
3. Seizures (Absence Seizure)
01/01/1997 - "A single dose of LTG (20 mg/kg) prevented audiogenic seizures in seizure-prone mice, while reducing substantially the striatal content of the DA metabolite, DOPAC (to less than 50% of saline-injected controls) in both seizure-resistant and seizure-prone mice. "
08/01/1994 - "Stimulation of the kindled hippocampus that produced stage 3 seizures evoked a brief increase in extracellular DA and DOPAC levels in the contralateral nucleus accumbens. "
12/01/1983 - "Neurochemically, there was a marked decrease in noradrenaline levels (up to 70%) and an increase in levels of 5-hydroxyindoleacetic acid, 3,4-dihydroxyphenylacetic acid and homovanillic acid (up to 200%) in all analysed brain regions, suggesting a strongly increased firing rate of aminergic neurones during the period of generalized seizures. "
06/01/2010 - "Kindling of seizures induced time-, seizure-, and structure-dependent increases in the local levels of NA, 5-HT, 5-hydroxyindolacetic acid, DA, homovanillic acid, and 3,4-dihydroxyphenylacetic acid. "
07/15/1985 - "There was a positive correlation between the dose of kainic acid and the extent of both the acute neurochemical changes 3 h after the injection (increases of 3,4-dihydroxyphenylacetic acid and 5-hydroxyindoleacetic acid levels and a decrease in noradrenaline levels in all brain regions investigated), the acute histopathological changes (shrinkage and condensation of nerve cells and brain oedema in the entire forebrain) and the extent of behavioural alterations (immobility, 'wet dog shakes' and limbic seizures). "
4. Inflammation (Inflammations)
5. Gliosis

Related Drugs and Biologics

1. Dopamine (Intropin)
2. Homovanillic Acid
3. Acids
4. Norepinephrine (Noradrenaline)
5. Hydroxyindoleacetic Acid
6. Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
7. Dihydroxyphenylalanine (Dopa)
8. 3-methoxytyramine (methoxytyramine)
9. Levodopa (L Dopa)
10. 1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)

Related Therapies and Procedures

1. Injections
2. Oral Administration
3. Intravenous Administration
4. Catheters
5. Orthopedic Procedures