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3-Hydroxysteroid Dehydrogenases (3 beta Hydroxysteroid Dehydrogenase)

Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.
Also Known As:
3 beta Hydroxysteroid Dehydrogenase; 3 Hydroxysteroid Dehydrogenases; Dehydrogenase, 3-beta-Hydroxysteroid; Dehydrogenases, 3 Hydroxysteroid; Dehydrogenases, 3-Hydroxysteroid; Hydroxysteroid Dehydrogenases, 3; 3-beta-Hydroxysteroid Dehydrogenase
Networked: 149 relevant articles (5 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Jiang, Guoli: 1 article (11/2015)
2. Yun, Young Won: 1 article (11/2015)
3. Oladele, Oso Abimbola: 1 article (11/2015)
4. Lee, Beom Jun: 1 article (11/2015)
5. Fan, Juexin: 1 article (11/2015)
6. Wang, Shengping: 1 article (11/2015)
7. Baek, In-Jeoung: 1 article (11/2015)
8. Ding, Hao: 1 article (11/2015)
9. Xiao, Dingfu: 1 article (11/2015)
10. Yon, Jung-Min: 1 article (11/2015)

Related Diseases

1. Body Weight (Weight, Body)
05/01/1992 - "Treatment with DHT caused a dose-dependent inhibition of testicular 3 beta-hydroxysteroid dehydrogenase/delta 5-4 isomerase (3 beta-HSD) 2 h later, and this effect was apparent at the dose of 20 micrograms/100 g body weight (P less than 0.01). "
07/01/1984 - "However, no significant difference in body weight and in the weights of adrenals, uteri and ovaries and in the adrenal delta 5 3 beta-hydroxysteroid dehydrogenase (HSD) activity was found between unisexually grouped females and individually housed females. "
12/01/1999 - "Significant reduction of testicular and accessory sex organs (seminal vesicle, ventral prostate) weight, along with inhibition of testicular delta 5-3 beta-hydroxysteroid dehydrogenase (delta 5-3 beta-HSD) and 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activity and reduction in plasma testosterone level, were observed at the doses of 2000 and 3000 micrograms/kg body weight/day. "
08/01/2002 - "Cyclophosphamide treatment at the dose of 5 mg/kg body weight/day for 28 days resulted a significant diminution in the activities of testicular delta 5, 3 beta-hydroxysteroid dehydrogenase (delta 5, 3 beta-HSD), 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activities, plasma level of testosterone along with significant reduction in the number of germ cells at stage-VII of spermatogenesis. "
04/01/1989 - "3 beta-hydroxysteroid dehydrogenase (EC 1.1.1.145, 3 beta-HSD) and 17 beta-hydroxysteroid dehydrogenase (EC 1.1.1.64, 17 beta-HSD); cytosolic conjugation enzyme, glutathione-S-transferase (EC 2.5.1.18); and testicular as well as serum testosterone levels at the dose levels of 2.5, 5.0, 7.5 and 10 mg/kg body weight fed orally for 7 and 15 days. "
2. Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal)
3. Cushing Syndrome
4. Neoplasms (Cancer)
5. Adrenocortical Adenoma (Disease, Conn's)

Related Drugs and Biologics

1. Oxidoreductases
2. Testosterone (Sustanon)
3. Enzymes
4. trilostane
5. Hydrocortisone (Cortisol)
6. Estradiol (Estrace)
7. Hormones
8. Peroxidase (Myeloperoxidase)
9. Follicle Stimulating Hormone (Follitropin)
10. Cyclophosphamide (Cytoxan)

Related Therapies and Procedures

1. Continuous Ambulatory Peritoneal Dialysis (CAPD)
2. Ovariectomy (Oophorectomy)
3. Adrenalectomy