3-Deazauridine (3 Deazauridine)

01/01/1980 - "Phase I study of 3-deazauridine in the treatment of adults with solid tumors."
10/01/1979 - "Penetration of 3-deazauridine into human brain, intracerebral tumor, and cerebrospinal fluid."
01/01/1980 - "A phase I trial of the uridine analog 3-deazauridine was undertaken in 44 adults with solid tumors. "
05/14/2009 - "The cytostatic activity of 3-fluoro-3-deazauridine (CC(50) = 4.4-9.6 microM) in three cancer cell lines paralleled that of 3-deazauridine, whereas no significant inhibitory activity was observed with a variety of virus-infected cell cultures."
06/01/1984 - "Cytotoxic and biochemical effects of thymidine and 3-deazauridine on human tumor cells."

05/01/1981 - "Phase I--II study of 3-deazauridine in adults with acute leukemia."
01/01/1974 - "Inhibition of gross leukemia virus-induced plaque formation in XC cells by 3-deazauridine."
03/01/1981 - "In vivo cellular kinetic and pharmacological studies of 1-beta-D-arabinofuranosylcytosine and 3-deazauridine chemotherapy for relapsing acute leukemia."
01/01/1991 - "Modulation of cytosine arabinoside toxicity by 3-deazauridine in a murine leukemia model."
05/01/1981 - "3-Deazauridine, a uridine analog, was administered to 36 patients with acute leukemia by both intermittent and continuous iv infusion at doses ranging from 400 to 6000 mg/m2/day x 5, repeated at 1--3-week intervals. "

02/01/1982 - "A phase II study of 3-deazauridine (DAUR) showed poor activity in previously treated patients with advanced colorectal adenocarcinoma. "
02/01/1982 - "Phase II study of 3-deazauridine in advanced colorectal adenocarcinoma."

06/01/1978 - "3-Deazauridine enhanced the anabolism of ara-C in nonleukemic lymphocytes in vitro and leukemia L1210 cells in vivo but did not influence ara-C anabolism in the other cell types. "
06/01/1983 - "Effect of 3-deazauridine on the metabolism, toxicity, and antitumor activity of azacitidine in mice bearing L1210 leukemia sensitive and resistant to cytarabine."
05/15/1989 - "Dual effects of pyrazofurin and 3-deazauridine upon pyrimidine and purine biosynthesis in mouse L1210 leukemia."

07/01/1976 - "The effects of D-galactosamine and 3-deazauridine on the growth of the Morris hepatoma cell lines 3924A, 8999S,AND 8999R were strongly synergistic; on the Novikoff hepatoma and the nonhepatic cell lines they were only additive. "
10/25/1978 - "The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine."