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25-Hydroxyvitamin D3 1-alpha-Hydroxylase (25 Hydroxyvitamin D3 1 alpha Hydroxylase)

A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Also Known As:
25 Hydroxyvitamin D3 1 alpha Hydroxylase; Calcidiol 1 Monooxygenase; CYP27B1; 25-Hydroxycholecalciferol-1-Hydroxylase; 25-Hydroxyergocalciferol 1-alpha-Hydroxylase; 25-Hydroxyvitamin D 1-alpha-Hydroxylase; 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase; 25-Hydroxyvitamin D2 1-hydroxylase; 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol; 1-alpha-Hydroxylase, 25-Hydroxyvitamin D; 1-hydroxylase, 25-Hydroxyvitamin D2; 25 Hydroxycholecalciferol 1 Hydroxylase; 25 Hydroxyergocalciferol 1 alpha Hydroxylase; 25 Hydroxyvitamin D 1 alpha Hydroxylase; 25 Hydroxyvitamin D2 1 hydroxylase; Cytochrome P 450 CYP27B1; 25-Hydroxycholecalciferol 1-Hydroxylase; Calcidiol 1-Monooxygenase; Cytochrome P-450 CYP27B1; Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
Networked: 190 relevant articles (2 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Cross, Heide S: 10 articles (01/2012 - 06/2002)
2. Kállay, Enikö: 7 articles (01/2012 - 06/2002)
3. Reichrath, Jörg: 6 articles (07/2012 - 05/2004)
4. Meese, Eckart: 6 articles (06/2010 - 01/2003)
5. Peters, Ulrike: 5 articles (01/2015 - 10/2007)
6. Badenhoop, Klaus: 5 articles (01/2014 - 05/2004)
7. Fischer, Ulrike: 5 articles (06/2010 - 01/2003)
8. Seifert, Markus: 5 articles (09/2009 - 05/2004)
9. Lechner, Daniel: 5 articles (07/2006 - 12/2003)
10. Slominski, Andrzej T: 4 articles (02/2015 - 03/2013)

Related Diseases

1. Neoplasms (Cancer)
2. Vitamin D Deficiency
3. Prostatic Neoplasms (Prostate Cancer)
4. Breast Neoplasms (Breast Cancer)
5. Multiple Sclerosis

Related Drugs and Biologics

1. hydroxide ion
2. Vitamin D
3. Calcitriol Receptors (Calcitriol Receptor)
4. Vitamin D-Binding Protein
5. vitamin D 24-hydroxylase (CYP24)
6. 25-hydroxyvitamin D
7. 1,25-dihydroxyvitamin D
8. Proteins (Proteins, Gene)
9. Factor IX (PTC)
10. Peroxisome Proliferator-Activated Receptors (PPAR)

Related Therapies and Procedures

1. Resistance Training
2. Injections
3. Exercise Therapy (Therapy, Exercise)