25-Hydroxyvitamin D3 1-alpha-Hydroxylase (25 Hydroxyvitamin D3 1 alpha Hydroxylase)

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66 relevant articles (2 outcomes, 8 trials/studies) found for this Bio-Agent

Description: A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).

Also Known As:

25 Hydroxyvitamin D3 1 alpha Hydroxylase; Calcidiol 1 Monooxygenase; CYP27B1; 25-Hydroxycholecalciferol-1-Hydroxylase; 25-Hydroxyergocalciferol 1-alpha-Hydroxylase; 25-Hydroxyvitamin D 1-alpha-Hydroxylase; 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase; 25-Hydroxyvitamin D2 1-hydroxylase; 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol; 1-alpha-Hydroxylase, 25-Hydroxyvitamin D; 1-hydroxylase, 25-Hydroxyvitamin D2; 25 Hydroxycholecalciferol 1 Hydroxylase; 25 Hydroxyergocalciferol 1 alpha Hydroxylase; 25 Hydroxyvitamin D 1 alpha Hydroxylase; 25 Hydroxyvitamin D2 1 hydroxylase; Cytochrome P 450 CYP27B1; 25-Hydroxycholecalciferol 1-Hydroxylase; Calcidiol 1-Monooxygenase; Cytochrome P-450 CYP27B1; Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Meese, Eckart: 3 articles (07/2006 - 01/2003)
2.	Diesel, Britta: 3 articles (07/2006 - 01/2003)
3.	Fischer, Ulrike: 3 articles (07/2006 - 01/2003)
4.	Badenhoop, Klaus: 3 articles (09/2005 - 05/2004)
5.	Dwivedi, Prem P: 2 articles (03/2007 - 06/2005)
6.	Anderson, Paul H: 2 articles (03/2007 - 06/2005)
7.	Morris, Howard A: 2 articles (03/2007 - 06/2005)
8.	May, Brian K: 2 articles (03/2007 - 06/2005)
9.	Reichrath, Jörg: 2 articles (07/2006 - 08/2005)
10.	Radermacher, Jens: 2 articles (07/2006 - 08/2005)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2008 - "25-Hydroxyvitamin D-1 alpha-hydroxylase (CYP27B1) is a new class of tumor suppressor in the prostate." 07/01/2006 - "Expression of CYP27B1 was found in all tumor tissues" 07/01/2006 - "Here, this approach was used to analyze the expression of CYP27B1 and its splice variants in normal tissues, tumor tissues and cell cultures" 07/01/2006 - "Expression analysis of CYP27B1 in tumor biopsies and cell cultures." 03/01/2007 - "Alterations in 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) activity have been found in some tumor cells, but there are no studies performed in human choriocarcinoma" Get all the results and reference details, order at left...
2.	Vitamin D Deficiency 10/01/2008 - "Absence of a functional VDR or the key activating enzyme, 25-OHD-1alpha-hydroxylase (CYP27B1), in mice creates a bone and growth plate phenotype that mimics humans with the same congenital disease or severe vitamin D deficiency" 10/01/2008 - "Lack of Cyp27b1 exacerbates disease in this model, suggesting that similar effects may occur with vitamin D deficiency." 02/01/2005 - "Vitamin D deficiency resulted in an increase in both the reporter gene and CYP27B1 expression" 08/01/2008 - "Gestational diabetes mellitus and vitamin D deficiency: genetic contribution of CYP27B1 and CYP2R1 polymorphisms." 02/01/2003 - "Mutations in the human 25-hydroxyvitamin-D(3)-1alpha-hydroxylase (CYP27B1) gene cause pseudo vitamin D deficiency rickets (PDDR)" Get all the results and reference details, order at left...
3.	Prostatic Neoplasms (Prostate Cancer) 06/01/2005 - "These studies provide the basis for a more detailed understanding of CYP27B1 repression in prostate cancer cells and could provide a novel insight in future diagnosis and treatment." 11/01/2002 - "CONCLUSION: This study suggests that the CYP27B1 gene does not play a major role as a prostate cancer susceptibility gene." 10/01/2007 - "Genotypes of CYP27B1 and CYP24A1 were not associated with prostate cancer risk" 06/01/2005 - "First, we identify a repressive region between -997 and -1200 in the human CYP27B1 promoter following transient transfection analysis in the prostate cancer cell lines DU145, PC3 and LNCaP" 06/01/2005 - "CYP27B1 is substantially repressed in prostate cancer cells" Get all the results and reference details, order at left...
4.	Breast Neoplasms (Breast Cancer) 07/01/2006 - "The aims of this study were to: i) assess the association between breast cancer risk and plasma 25OHD3 concentration and ii) define the significance of expression of the 25OHD activating enzyme CYP27b1 in non-malignant and malignant models of breast epithelial cells" 01/01/2007 - "Since the down regulation of the CYP27B1 gene is tissue- and cell-type selective, a comparative study was done for the new 1alpha,25(OH)2D3-responsive regions in HEK-293 human embryonic kidney and MCF-7 human breast cancer cells that reflect tissues that, respectively, are permissive and non-permissive to the phenomenon of 1alpha,25(OH)2D3-mediated down-regulation of this gene" 04/01/2006 - "These are the first studies to demonstrate that nontransformed human mammary cells express CYP27B1, that they are growth inhibited by physiologically relevant concentrations of 25(OH)D3, and that they provide a biological mechanism linking vitamin D status to breast cancer risk." Get all the results and reference details, order at left...
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