2',5'-Oligoadenylate Synthetase (2',5' Oligoadenylate Synthetase)

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214 relevant articles (3 outcomes, 12 trials/studies) found for this Bio-Agent

Description: An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions. EC 2.7.7.-.

Also Known As:

2',5' Oligoadenylate Synthetase; (2'-5')An Polymerase; 2',5'-Oligo(A) Polymerase; 2',5'-Oligo(A) Synthetase; 2,5 Oligoadenylate Polymerase; 2,5 Oligoadenylate Synthetase; ATP-(2'-5')oligo(A)adenylyltransferase; 2 5A Synthetase; 2',5' Oligoadenylate Polymerase; Oligoadenylate Polymerase, 2,5; Oligoadenylate Synthetase, 2,5; Polymerase, 2',5'-Oligoadenylate; Polymerase, 2,5 Oligoadenylate; Synthetase, 2',5'-Oligoadenylate; Synthetase, 2,5 Oligoadenylate; 2',5'-Oligoadenylate Polymerase; 2-5A Synthetase

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1

Enzymes: 24340

Transferases: 3170

Phosphotransferases: 14916

Nucleotidyltransferases: 2

2',5'-Oligoadenylate Synthetase: 214

p30 oligoadenylate synthetase

p56 oligoadenylate synthetase

Experts

1.	Xu, Jie: 1 article (10/2007)
2.	Jiang, Jie-Hong: 1 article (10/2007)
3.	Jiang, Jie-hong: 1 article (10/2007)
4.	Jin, Gen-di: 1 article (10/2007)
5.	Zhang, Xin-xin: 1 article (10/2007)
6.	Sun, Xiao-fei: 1 article (10/2007)
7.	Lu, Zhi-Meng: 1 article (10/2007)
8.	Lu, Zhi-meng: 1 article (10/2007)
9.	Lu, Min: 1 article (10/2007)
10.	Gong, Qi-ming: 1 article (10/2007)

Related Diseases

1.	Chronic Hepatitis C 05/01/1997 - "Serum 2',5'-oligoadenylate synthetase concentrations in acute and chronic hepatitis C." 10/01/1993 - "It was our aim to evaluate whether the baseline activity of 2-5 oligoadenylate synthetase (2-5 OAS) in serum and changes induced by the treatment with interferon are relevant factors in remission of chronic hepatitis C" 02/01/1996 - "Effect of alpha interferon (IFN-alpha) on 2'-5' oligoadenylate synthetase activity in peripheral blood mononuclear cells of patients with chronic hepatitis C: relationship to the antiviral effect of IFN-alpha." 10/01/1995 - "Activity of the interferon-induced 2',5'-oligoadenylate synthetase in patients with chronic hepatitis C." 12/01/1994 - "Longitudinal changes in lymphocyte subpopulations, including total and activated T cells, B cells, and NK cells as well as NK activity and 2',5'-oligoadenylate synthetase (2'5' AS) levels were determined in peripheral blood before, during, and after therapy with human recombinant interferon-alpha (HurIFN-alpha) in 39 patients with serologically and biopsy-confirmed chronic hepatitis C" Get all the results and reference details, order at left...
2.	Hepatitis 01/01/1989 - "In acute hepatitis patients, an early but transient elevation of 2',5'-oligoadenylate synthetase was observed; the mean level at 1 week was significantly greater than the mean level at 4 weeks after the onset of their illness (p less than 0.01)" 05/01/1997 - "Serum 2',5'-oligoadenylate synthetase concentration in the acute stage of hepatitis was above 200 pmol/dL in all four patients who recovered and in only of two of the remaining 10 patients (p < 0.02, Fisher's exact test)" 06/01/1991 - "2'-5' oligoadenylate synthetase activity in patients with acute viral hepatitis and chronic type B hepatitis, and its clinical significance]" 04/01/1991 - "Persistent detection of raised 2',5' oligoadenylate synthetase activity levels during the acute stage of non-A, non-B hepatitis may thus be an indicator of progression of the disease." 04/01/1991 - "We measured the sequential changes in 2',5' oligoadenylate synthetase activity in 21 patients with acute viral hepatitis (5 with type A, 6 with type B, and 10 with type non-A, non-B hepatitis) by radioimmunoassay" Get all the results and reference details, order at left...
3.	Syndrome 03/01/1986 - "Spontaneous production of the interferon induced enzyme 2',5'-oligoadenylate synthetase (2',5'-A synthetase) was significantly greater in blood lymphocytes of patients with systemic lupus erythematosus (SLE), Behçet's syndrome, and rheumatoid arthritis than in control lymphocytes" 04/01/1984 - "The activity of the interferon-induced enzyme 2',5'-oligoadenylate synthetase (2',5' An synthetase) was found to be increased in the lysates of peripheral blood mononuclear leukocytes obtained from 10 of 25 (40%) patients with cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome)" 01/01/1998 - "Downregulation of RNase L inhibitor correlates with upregulation of interferon-induced proteins (2-5A synthetase and RNase L) in patients with chronic fatigue immune dysfunction syndrome." Get all the results and reference details, order at left...
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/01/1983 - "The interferon (IFN)-induced enzyme 2-5A synthetase was elevated in mononuclear cells from both serum IFN-positive and -negative systemic lupus erythematosus (SLE) patients" 03/01/1986 - "Spontaneous production of the interferon induced enzyme 2',5'-oligoadenylate synthetase (2',5'-A synthetase) was significantly greater in blood lymphocytes of patients with systemic lupus erythematosus (SLE), Behçet's syndrome, and rheumatoid arthritis than in control lymphocytes" Get all the results and reference details, order at left...
5.	Rheumatoid Arthritis 03/01/1986 - "Spontaneous production of the interferon induced enzyme 2',5'-oligoadenylate synthetase (2',5'-A synthetase) was significantly greater in blood lymphocytes of patients with systemic lupus erythematosus (SLE), Behçet's syndrome, and rheumatoid arthritis than in control lymphocytes" Get all the results and reference details, order at left...
91 Diseases and 214 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Interferons
2.	Interferon-alpha (Interferon Alfa)
3.	Neopterin
4.	Proteins (Proteins, Gene)
5.	Messenger RNA (mRNA)
6.	Hepatitis B e Antigens
7.	Antigens
8.	2',5'-oligoadenylate (PAPAPA)
9.	Estradiol (Estrace)
10.	Bile Acids and Salts (Bile Acids)
99 Drugs and Important Bio-Agents and 164 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Transplants (Transplant)
2 Therapies and Procedures and 5 more articles analyzed in the Research Interface, order at left...

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