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2',5'-Oligoadenylate Synthetase (2',5' Oligoadenylate Synthetase)

An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.
Also Known As:
2',5' Oligoadenylate Synthetase; (2'-5')An Polymerase; 2',5'-Oligo(A) Polymerase; 2',5'-Oligo(A) Synthetase; 2,5 Oligoadenylate Polymerase; 2,5 Oligoadenylate Synthetase; ATP-(2'-5')oligo(A)adenylyltransferase; 2',5' Oligoadenylate Polymerase; Oligoadenylate Polymerase, 2,5; Oligoadenylate Synthetase, 2,5; Polymerase, 2',5'-Oligoadenylate; Polymerase, 2,5 Oligoadenylate; Synthetase, 2',5'-Oligoadenylate; Synthetase, 2,5 Oligoadenylate; 2',5'-Oligoadenylate Polymerase; 2-5A Synthetase
Networked: 269 relevant articles (3 outcomes, 20 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Silverman, Robert H: 6 articles (01/2020 - 02/2005)
2. De Meirleir, Kenny: 4 articles (02/2007 - 01/2004)
3. Kang, Yinfeng: 3 articles (03/2019 - 09/2018)
4. Wang, Ruining: 3 articles (03/2019 - 09/2018)
5. Zhao, Mengmeng: 3 articles (03/2019 - 09/2018)
6. Lee, Myeong Sup: 3 articles (01/2019 - 01/2016)
7. Sim, Chan Kyu: 3 articles (01/2019 - 01/2016)
8. Desprès, Philippe: 3 articles (08/2011 - 06/2003)
9. Frenkiel, Marie-Pascale: 3 articles (08/2011 - 06/2003)
10. Williams, Bryan R G: 3 articles (08/2006 - 02/2005)

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Related Drugs and Biologics

1. Interferons
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