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2',5'-Oligoadenylate Synthetase (2',5' Oligoadenylate Synthetase)

An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions. EC 2.7.7.-.
Also Known As:
2',5' Oligoadenylate Synthetase; (2'-5')An Polymerase; 2',5'-Oligo(A) Polymerase; 2',5'-Oligo(A) Synthetase; 2,5 Oligoadenylate Polymerase; 2,5 Oligoadenylate Synthetase; ATP-(2'-5')oligo(A)adenylyltransferase; 2 5A Synthetase; 2',5' Oligoadenylate Polymerase; Oligoadenylate Polymerase, 2,5; Oligoadenylate Synthetase, 2,5; Polymerase, 2',5'-Oligoadenylate; Polymerase, 2,5 Oligoadenylate; Synthetase, 2',5'-Oligoadenylate; Synthetase, 2,5 Oligoadenylate; 2',5'-Oligoadenylate Polymerase; 2-5A Synthetase
Networked: 240 relevant articles (3 outcomes, 15 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Silverman, Robert H: 5 articles (06/2012 - 02/2005)
2. De Meirleir, Kenny: 5 articles (02/2007 - 01/2003)
3. Frenkiel, Marie-Pascale: 3 articles (08/2011 - 06/2003)
4. Desprès, Philippe: 3 articles (08/2011 - 06/2003)
5. Williams, Bryan R G: 3 articles (08/2006 - 02/2005)
6. Nijs, Jo: 3 articles (11/2005 - 01/2003)
7. Englebienne, Patrick: 3 articles (06/2005 - 01/2003)
8. Song, Cuiping: 2 articles (12/2014 - 05/2014)
9. Cheng, Anchun: 2 articles (12/2014 - 05/2014)
10. Ding, Chan: 2 articles (12/2014 - 05/2014)

Related Diseases

1. Chronic Hepatitis C
2. Hepatitis
3. Systemic Lupus Erythematosus (Libman-Sacks Disease)
4. Rheumatoid Arthritis
5. Infection

Related Drugs and Biologics

1. Interferons
2. Interferon-alpha (Interferon Alfa)
3. Messenger RNA (mRNA)
4. Proteins (Proteins, Gene)
5. Neopterin
6. Hepatitis B e Antigens
7. Antigens
8. 2',5'-oligoadenylate (PAPAPA)
9. Estradiol (Estrace)
10. Bile Acids and Salts (Bile Acids)

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Transplants (Transplant)
3. Injections