|1.||Leifsson, P S: 2 articles (05/2013 - 07/2011)|
|2.||Jensen, H E: 2 articles (05/2013 - 07/2011)|
|3.||Barradas, P C: 2 articles (04/2007 - 10/2001)|
|4.||Yu, Hui-Min: 2 articles (01/2007 - 01/2005)|
|5.||Gu, Wei-Zhong: 2 articles (01/2007 - 01/2005)|
|6.||Yuan, Tian-Ming: 2 articles (01/2007 - 01/2005)|
|7.||Woo, Tsung-Ung W: 1 article (12/2015)|
|8.||Pietersen, Charmaine Y: 1 article (12/2015)|
|9.||Mauney, Sarah A: 1 article (12/2015)|
|10.||Sonntag, Kai-C: 1 article (12/2015)|
|1.||Demyelinating Diseases (Demyelinating Disease)
07/01/2012 - "These findings suggest that CNPase expression was induced in the course of restoration following HCP-induced insults to oligodendroglia and the myelin sheath, and in the course of demyelination by CPZ-induced damage to oligodendroglia. "
01/01/2008 - "Axonal loss was detected in the right eye of the Thy1-CFP mice, and demyelination was detected in the CNPase-GFP mice. "
06/01/1993 - "The correlation of the decrease in CNPase and MBP levels with the incidence of transient neurological malfunction and animal death, together with histological evidence, suggests that demyelination is responsible for these phenomena."
11/01/1990 - "CNPase was not decreased in its activity at 7 days, but decreased at 14 days, supporting progressive demyelination. "
01/01/1986 - "It was considered that the reduction of CNPase activity and its recovery and increase reflect demyelination and activation of oligodendroglia for remyelination, respectively."
03/01/2015 - "In some patients with multiple sclerosis, paranodal CNPase and juxtaparanodal contactin-2 trigger a humoral response. "
05/01/1997 - "Furthermore we describe for the first time several rh-CNPase specific T-cell lines from a multiple sclerosis patient and a healthy control."
12/01/1996 - "We have analysed the entire expressed sequence of the human CNPase gene in patients with multiple sclerosis and in healthy controls using single strand conformation polymorphism (SSCP) analysis. "
01/01/1984 - "We concluded that CNPase activity in the cerebrospinal fluid from neurological patients is an indicator of destruction of myelin in the central nervous system, and the measurement of CNPase activity in the cerebrospinal fluid of multiple sclerosis could be useful in the clinical management."
01/01/1984 - "The level of CNPase activity in the cerebrospinal fluid of multiple sclerosis coincided with the clinical activity of the disease. "
|3.||Brain Injuries (Brain Injury)
01/01/2014 - "This study extended the investigation to determine CNPase expression in activated microglia derived from cell culture and animal models of brain injury with the objective to clarify its putative functions. "
12/01/2014 - "In addition to a role in myelination, CNPase is also involved in local adenosine production in traumatic brain injury and possibly has a regulatory function in mitochondrial membrane permeabilization. "
07/01/2012 - "Microdialysis experiments in 2',3'-cyclic nucleotide-3'-phosphodiesterase (CNPase) wild-type mice demonstrated that traumatic brain injury (controlled cortical impact model) activated the brain 2',3'-cAMP-adenosine pathway; similar experiments in CNPase knockout mice indicated that CNPase was involved in the metabolism of endogenous 2',3'-cAMP to 2'-AMP and to adenosine. "
01/01/1992 - "This study showed that demyelination, as assessed by the levels of the myelin-associated proteins MBP and CNPase, can occur soon after spinal cord irradiation but that profound dose-dependent changes are seen only immediately preceding the onset of paralysis. "
01/01/1990 - "The criteria for evaluation of the drug effect were changes in body weight, activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase), clinical manifestations such as paralysis of lower extremities and histopathological changes. "
|5.||Brain Ischemia (Cerebral Ischemia)
10/01/2010 - "In this study, we investigated acute changes in the ipsilateral hippocampus from 1 up to 7 days after 90 min of transient focal cerebral ischemia in rats, using anti-NeuN (neuronal nuclei), anti-Cu/Zn-superoxide dismutase (Cu/Zn-SOD), anti-Mn-SOD, anti-neuronal nitric oxide synthase (nNOS), anti-inducible NOS (iNOS), anti-glial fibrillary acidic protein (GFAP), anti-ionized calcium-binding adaptor molecule 1(Iba 1) and anti-2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) antibodies. "
|1.||Proteins (Proteins, Gene)
|3.||Glial Fibrillary Acidic Protein
|6.||Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)