2-Isopropylmalate Synthase (2 Isopropylmalate Synthase)

An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12.

Also Known As:

2 Isopropylmalate Synthase; alpha-Isopropylmalate Synthase; Synthase, 2-Isopropylmalate; Synthase, alpha-Isopropylmalate; alpha Isopropylmalate Synthase; 3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - 2-Isopropylmalate Synthase: 1
        Arabidopsis MAM3 protein
        S cerevisiae LEU4 protein
        S cerevisiae LEU9 protein

Related Diseases

1.	Starvation 08/01/1994 - "Conversely, starvation for tryptophan caused a slight elevation of alpha-isopropylmalate synthase and starvation for leucine caused a significant increase of anthranilate synthase and tryptophan synthase specific activities. "

Related Drugs and Biologics

1.	Tryptophan Synthase (Synthase, Tryptophan)
2.	Tryptophan (L-Tryptophan)
3.	Leucine (L-Leucine)
4.	Anthranilate Synthase