2-Isopropylmalate Synthase (2 Isopropylmalate Synthase)

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3 relevant articles (0 outcomes, 0 trials/studies) found for this Bio-Agent

Description: An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12.

Also Known As:

2 Isopropylmalate Synthase; alpha-Isopropylmalate Synthase; Synthase, 2-Isopropylmalate; Synthase, alpha-Isopropylmalate; alpha Isopropylmalate Synthase; 3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1

Enzymes: 24340

Transferases: 3170

Acyltransferases: 11

2-Isopropylmalate Synthase: 3

Arabidopsis MAM3 protein

S cerevisiae LEU4 protein

Related Diseases

1.	Tuberculosis 01/01/2007 - "BACKGROUND: Alpha-isopropylmalate synthase (MtalphaIPMS), an enzyme that catalyzes the first committed step of the leucine biosynthetic pathway of Mycobacterium tuberculosis is a potential drug target for the anti-tuberculosis drugs" Get all the results and reference details, order at left...
2.	Starvation 08/01/1994 - "Conversely, starvation for tryptophan caused a slight elevation of alpha-isopropylmalate synthase and starvation for leucine caused a significant increase of anthranilate synthase and tryptophan synthase specific activities" Get all the results and reference details, order at left...
3.	Contagious Ecthyma (Orf) 04/01/2000 - "A mutant in which both ORF YOR108w and LEU4 gene have been deleted proved to be leucine auxotrophic and alpha-isopropylmalate synthase (alpha-IPMS)-negative" Get all the results and reference details, order at left...
3 Diseases and 3 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Leucine (L-Leucine)
2.	Tryptophan Synthase (Synthase, Tryptophan)
3.	Tryptophan (L-Tryptophan)
4.	Anthranilate Synthase
4 Drugs and Important Bio-Agents and 3 more articles analyzed in the Research Interface, order at left...

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