1-Methyl-3-isobutylxanthine (1 Methyl 3 isobutylxanthine)

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147 relevant articles (2 outcomes, 12 trials/studies) found for this Bio-Agent

Description: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES

Also Known As:

1 Methyl 3 isobutylxanthine; IBMX; 3 Isobutyl 1 methylxanthine; 3-Isobutyl-1-methylxanthine; Isobutyltheophylline; 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

2-Ring Heterocyclic Compounds

1-Methyl-3-isobutylxanthine: 147

isbufylline: 3

1-isoamyl-3-isobutylxanthine

7-benzyl-3-(2-methylpropyl)xanthine

Experts

1.	Ervin, Heather D: 1 article (06/2002)
2.	Geisbuhler, Timothy P: 1 article (06/2002)
3.	Schwager, Tammie L: 1 article (06/2002)

Related Diseases

1.	Ataxia (Dyssynergia) 10/20/1986 - "Significantly greater ethanol-induced motor incoordination was seen in animals fed IBMX, 30 and 60 mg/kg/24 h, compared to controls" 01/01/1987 - "A significant potentiation of ethanol-induced ataxia was produced in all strains of mice at 20, 45 and 75 min after ethanol in mice pretreated with 62.5 mg/kg caffeine and 12.5 mg/kg IBMX" 10/20/1986 - "Ethanol-induced increased motor incoordination in caffeine and IBMX-fed animals was also associated with significantly greater 3H-R-PIA binding in whole brains compared to tap water controls indicating an increase in brain adenosine binding sites" 01/01/1987 - "The effect of the methylxanthines caffeine, theophylline and isobutylmethylxanthine (IBMX) on ethanol-induced ataxia and loss of righting reflex was investigated in three strains of mice" 10/20/1986 - "The increased motor incoordination associated with increased adenosine binding sites in the brains of caffeine and IBMX-fed animals suggests an involvement of central adenosine mechanisms in the motor incoordinating effect of ethanol and further supports our earlier suggestion for the role of adenosine in some of the central effects of ethanol." Get all the results and reference details, order at left...
2.	Herpes Zoster 01/01/1993 - "Forskolin was more effective in zona-free oocytes than in cumulus-enclosed oocytes in inhibiting nuclear maturation (24% mature oocytes versus 73% in control medium) even after 24 h of culture; its effect was potentiated by IBMX; forskolin also stimulated cAMP synthesis.(ABSTRACT TRUNCATED AT 250 WORDS)" Get all the results and reference details, order at left...
3.	Melanoma (Melanoma, Malignant) 10/01/2005 - "Melanoma cells homozygous for either the Arg151Cys variant or consensus sequence both elicited CREB phosphorylation in response to alpha-MSH in the presence of IBMX" 05/01/2000 - "Individual clones of lung metastasis cells expressed enhanced pigmentation, motility, and responsiveness to MSH/IBMX, a behavior similar to that recently reported for artificially generated melanoma x macrophage fusion hybrids" 10/01/2004 - "Here we report that long-term application of hypergravity (up to 5 g for 24 h) stimulated cGMP efflux in cultured melanocytes and in non-metastatic melanoma cells in the presence of 0.1 mM 3-isobutyl-1-methylxanthine (IBMX), a non-selective phosphodiesterase (PDE) inhibitor" 01/01/2003 - "Again, the metastatic hybrids, but not the nonmetastatic hybrids or parental melanoma cells, showed significant motile response to rHGF chemoattractant, and that motility is further induced when cells were stimulated with MSH/isobutylmethyl xanthine (IBMX)" 03/01/2008 - "Ten compounds were isolated from the EtOAc soluble part of the MeOH extract of Saussureae Radix, with their effects on melanin production also evaluated in B-16 mouse melanoma cell lines stimulated with 3-isobutyl-1-methylxanthine (IBMX), an elevator of cellular cAMP" Get all the results and reference details, order at left...
4.	Glioma (Gliomas) 08/01/1992 - "If used in concentrations that induce growth arrest, both 8CPTcAMP and IBMX, but not 8ClcAMP, induced morphological differentiation of the glioma cells" 07/01/1979 - "The effect of dibutyryl cAMP could be mimicked by prostaglandin E1 and 3-isobutyl-1-methylxanthine, both of which are known to raise cAMP levels in neuroblastoma-glioma hybrid cells" 04/01/1993 - "Neuroblastoma x glioma (NG108-15) hybrid cells transfected with m1 muscarinic receptors were grown with 1% fetal bovine serum (FBS) without the prostaglandin E1 (PGE1) and isobutylmethylxanthine (IBMX) usually added in preparation for electrophysiological studies" 12/10/1980 - "Using this technique, it was shown that isoproterenol + 3-isobutyl-1-methylxanthine and dibutyryl cAMP cause an increase of the [3H]leucine incorporation into glioma cell lactate dehydrogenase" 03/01/1993 - "Continuous elevation of intracellular cyclic AMP (cAMP) by culturing neuroblastoma x glioma NG108-15 hybrid cells in the presence of forskolin and isobutylmethylxanthine (IBMX) in a chemically defined medium resulted in differentiation of the hybrid cells, as indicated by extension of neurite-like structures and induction of a subclass of G-protein, Go, as monitored by Western analysis" Get all the results and reference details, order at left...
5.	Syndrome 01/01/1991 - "IBMX induces a quasi-morphine withdrawal syndrome (QMWS), which is almost identical to true morphine withdrawal both behaviorally and neurochemically" 01/01/1991 - "The use of IBMX in developing rats may also offer a model for studying the long-term consequences of the expression of opioid withdrawal during the neonatal period, since this agent induces a quasi-morphine withdrawal syndrome (QMWS) in mature rats" 03/01/1976 - "Proceedings: Stereospecific suppression by opiates of the quasi-morphine abstinence syndrome elicited by 3-isobutyl-l-methylxanthine (IBMX)." 01/01/1990 - "A quasi-morphine withdrawal syndrome (QMWS), produced in opiate-naive rats with an injection of isobutylmethylxanthine (IBMX) and the opioid antagonist naloxone, allows one to study the expression of opiate withdrawal in the absence of the acute or chronic effects of opiates and the adaptive processes termed dependence" 01/01/1976 - "In naive rats, the xanthines, theophylline and 3-isobutyl-1-methylxanthine, produce a quasimorphine-abstinence syndrome that is readily suppressed by heroin and intensified by nalosone" Get all the results and reference details, order at left...
78 Diseases and 147 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Forskolin
2.	Caffeine (No Doz)
3.	Adenosine
4.	Ethanol (Ethyl Alcohol)
5.	1-Methyl-3-isobutylxanthine (1 Methyl 3 isobutylxanthine)
6.	Theophylline (Theon)
7.	Melanins (Melanin)
8.	alpha-MSH
9.	methylxanthine
10.	Morphine (MS Contin)
156 Drugs and Important Bio-Agents and 128 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
1 Therapies and Procedures and 1 more articles analyzed in the Research Interface, order at left...

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