Zearalenone

(S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.

Also Known As:

Networked: 227 relevant articles (2 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gajęcka, Magdalena: 10 articles (01/2021 - 11/2013)
2.	Zielonka, Łukasz: 10 articles (01/2021 - 12/2013)
3.	Dąbrowski, Michał: 7 articles (01/2020 - 12/2013)
4.	Bacha, Hassen: 7 articles (07/2016 - 07/2007)
5.	Obremski, K: 7 articles (01/2015 - 01/2004)
6.	Gajecka, M: 7 articles (01/2013 - 01/2004)
7.	Gajecki, M: 6 articles (01/2012 - 01/2002)
8.	Abbès, Samir: 5 articles (10/2021 - 07/2007)
9.	Gajęcki, Maciej: 5 articles (12/2016 - 11/2013)
10.	Jakimiuk, E: 5 articles (04/2011 - 01/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2003 - "Both low- and high-dose zearalenone treatment significantly reduced incidence of mammary tumors > or =1 cm in diameter but did not influence latency (time between MNU administration and harvest of mammary tumor > or =1 cm in diameter) compared with untreated controls. " 02/01/2018 - "The search for factors that contribute to the development of cancer cells in reproductive organs should involve the detection of xenoestrogens, in particular zearalenone (ZEA) and its metabolites. " 01/01/2016 - "Some zearalenone analogues showed moderately enhanced cytotoxic activities against the two cancer cell lines. " 10/03/2014 - "Because mitochondrion is a key organelle involved in producing ROS and generating metabolic intermediates for biosynthesis, an iTRAQ-based mitoproteomics approach was employed to identify the molecular mechanism of zearalenone toxicity using mitochondria of mouse Leydig tumor cells (MLTC-1). " 01/01/2004 - "The aim of the monitoring of zearalenone presence in the blood plasma of women with neoplastic lesions in the reproductive tract was to asses whether the phytosteride is noted in the patients blood and whether the correlation exists between its presence and the incidence of particular neoplasm. "
2.	Inflammation (Inflammations) 10/30/2021 - "Efficacy of lactic acid bacteria supplementation against Fusarium graminearum growth in vitro and inhibition of Zearalenone causing inflammation and oxidative stress in vivo." 04/01/2023 - "Additionally zearalenone upregulated the inflammation and oxidative stress in cardiovascular cells. " 02/01/2023 - "Chronic exposure to zearalenone induces intestinal inflammation and oxidative injury in adult Drosophila melanogaster midgut." 01/01/2022 - "Zearalenone interferes with the sperm-triggered inflammation in the bovine uterus in vitro: Negative impact on sperm motility and survival." 08/01/2013 - "Effects of zearalenone on oxidative stress and inflammation in weanling piglets."
3.	Body Weight (Weight, Body) 09/15/2018 - "The aim of this study was to determine whether exposure to low doses of zearalenone (ZEN) induces changes in the serum biochemical profile and body weights (BW). " 08/01/2015 - "The study was performed on ten immature pigs divided into two groups: experimental group (n = 5), where zearalenone (10 μg/kg body weight) was given for 42 days, and control animals (n = 5), where placebo was administered. " 11/01/2020 - "From gestational day 14-21, female Sprague Dawley rats (60 days old) were gavaged with zearalenone (0, 2.5, 5, 10, and 20 mg/kg/day body weight). " 09/15/2018 - "Growth performance, selected blood biochemical parameters and body weights of pre-pubertal gilts fed diets supplemented with different doses of zearalenone (ZEN)." 06/01/2018 - "OBJECTIVE To determine the effect of subchronic oral exposure to zearalenone (ZEA) at a daily dose of 50 μg of ZEA/kg of body weight (an environmentally relevant concentration) on the reproductive system of rabbit bucks. "
4.	Mycotoxicosis (Fungus Poisoning) 01/01/2008 - "The present study deals with the influence of experimental ZEA mycotoxicosis on histopathological lesions in ovaries of bitches, which were administered zearalenone per os during anestrus phase for one hundred days. " 01/01/2008 - "The aim of the study was to determine the influence of experimental zearalenone (ZEA) mycotoxicosis on the ultrastructure of ovaries in bitches receving zearalenone for 100 days per os in the anestrus phase. " 11/01/1990 - "The method was tested with sheep urine from an experimental feeding trial and was used to confirm natural mycotoxicosis of cows affected with zearalenone. " 01/01/2015 - "Zearalenone (ZEA), as a toxic compound existing in contaminated food products, is found to induce mycotoxicosis that has a significant impact on the reproduction of domestic animals, especially pigs. " 09/01/2013 - "Zearalenone (ZEN) has been implicated in several cases of mycotoxicosis in farm animals and humans. "
5.	Breast Neoplasms (Breast Cancer) 02/01/2023 - "Zearalenone and its metabolite exposure directs oestrogen metabolism towards potentially carcinogenic metabolites in human breast cancer MCF-7 cells." 01/01/2020 - "Two case-control studies in Africa investigated the relationship between zearalenone and its metabolites and breast cancer risk, though conflicting results were reported. " 06/01/2015 - "Zearalenone and its metabolites in urine and breast cancer risk: a case-control study in Tunisia." 01/01/2003 - "Thus, short-duration zearalenone treatment in the prepubertal period suppressed subsequent mammary cancer occurrence but also severely damaged ovarian functions. " 05/01/2002 - "Removal of Cdk inhibitors through both sequestration and downregulation in zearalenone-treated MCF-7 breast cancer cells."

Related Drugs and Biologics

1.	deoxynivalenol
2.	Genistein
3.	Estrogen Receptors
4.	Mycotoxins
5.	nivalenol
6.	zearalenol
7.	Hormones (Hormone)
8.	Enzymes
9.	Steroids
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Ovariectomy (Oophorectomy)
3.	Intramuscular Injections
4.	Aftercare (After-Treatment)
5.	Adrenalectomy