Xylenes (Xylene)

A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

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Networked: 648 relevant articles (16 outcomes, 62 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Peng, Shiqi: 12 articles (01/2020 - 10/2005)
2.	Zhao, Ming: 12 articles (01/2020 - 10/2005)
3.	Su, Zi-Ren: 7 articles (01/2019 - 12/2011)
4.	Hosseinzadeh, Hossein: 7 articles (04/2017 - 03/2002)
5.	Bi, Lanrong: 7 articles (01/2017 - 10/2005)
6.	Li, Weifeng: 7 articles (12/2015 - 10/2012)
7.	Niu, Xiaofeng: 7 articles (12/2015 - 10/2012)
8.	Wu, Jianhui: 6 articles (01/2020 - 03/2010)
9.	Wang, Chao: 6 articles (02/2008 - 10/2005)
10.	Yang, Shilin: 5 articles (08/2021 - 01/2017)

Related Diseases

1.	Edema (Dropsy) 04/03/2017 - "Meanwhile, it significantly relieved the xylene-induced ear edema in the mouse ear swelling test, which manifested its anti-inflammatory property. " 03/08/2006 - "This drug was also effective in inhibiting xylene induced ear edema, and the percentage of inhibition came to 50% at dose of 80 microl/20 g. " 01/01/2023 - "In vivo studies confirmed the anti-inflammatory activity of 9c and 9j in a xylene-induced mice auricles edema model. " 01/01/2020 - "In the animal study, twenty-five male ICR mice were induced as ear edema by topical xylene, and the ear thickness of the mice was measured. " 12/01/2015 - "Further in vivo study revealed that ES treatment also remarkably inhibited xylene-induced mouse ear edema and MPO levels in mice ears. "
2.	Inflammation (Inflammations) 07/01/2012 - "As an anti-inflammatory trial, we established a mouse model of inflammation by applying xylene to the pinna, and equally randomized 60 Kunming mice to six groups as in the former experiment. " 09/05/2020 - "Anti-inflammatory activity was assessed in terms of xylene-induced inflammation. " 03/26/2015 - "Our results showed that all of the compounds tested exhibited a significant inhibition of xylene-induced inflammation in mice. " 06/01/2012 - "Our results showed that all of the derivatives tested exhibited a significant inhibition of xylene-induced inflammation in mice." 01/01/2012 - "Xylene induced TSLP production, resulting in an exacerbation of allergic inflammation. "
3.	Neoplasms (Cancer) 10/01/2008 - "Substitution of xylene with the PEG 2 linker also leads to a significant reduction in both tumor and liver uptake. " 01/01/2016 - "In vivo, 2 µmol/kg of BHIMHA showed additional actions of slowing the growth of the primary tumor of C57BL/6 mice and S180 mice as well as inhibiting xylene-induced ear edema of the mice. " 05/01/1997 - "Increased risks of lymphohematopoietic malignancies have been reported in some studies of persons exposed to toluene or xylene, but not in the two most informative studies on toluene. " 05/01/2012 - "The subchronic non-cancer hazard index (HI) of 5 for residents ≤ ½ mile from wells was driven primarily by exposure to trimethylbenzenes, xylenes, and aliphatic hydrocarbons. " 01/01/2012 - "Tumor samples were deparaffinized in xylene and treated with the monoclonal aromatase antibody 677. "
4.	Pain (Aches) 07/01/2015 - "EECTD (300mg/kg) significantly reduced the number of writhing, extended the pain response latency, and suppressed xylene-induced ear swelling. " 05/01/2007 - "AKM had obvious anti-inflammatory effect on the xylene-induced ear tumefaction and inhibited the pain-caused body bend in the AKM groups, with significant difference from the normal control (P < 0.01). " 03/01/2022 - "Both fractions increased the percentage of maximum possible effect with 25 mg/kg, in the hot-plate assay, at 60 min, while AEEm reduced pain only with 50 and 100 mg/kg. There was a reduction in xylene-edema index, with Fr40 (25 mg/kg), AEEm (50 mg/kg) and Fr20 (50 mg/kg). " 11/30/2023 - "The pCTE exhibited a more potent anti-inflammatory effect; it also inhibited pain induced by xylene and acetic acid in mice. " 01/01/2015 - "We found that EMP reduced xylene-induced ear edema and relieved both acetic acid-induced pain and pain in the hot plate test. "
5.	Cough 07/01/2000 - "Xylene-induced ear swelling in mice, SO2-induced cough in mice, expectorant experiment on phenolsulfon phthalein excretion and bacteria incubation in vitro, etc. The total alkaloids of both FPA and FDA(i.g., 400 mg.kg-1 and 200 mg.kg-1) have anti-inflammatory, antibechic and expectorant effects, but the former is more effective than the latter. " 11/01/2021 - "The mouse auricle swelling was induced by xylene for detecting the anti-inflammatory effect of Qinbaohong Oral Liquid, whose antitussive effect was then examined in mice with cough after exposure to ammonium hydroxide. " 04/22/2015 - "Shionone at 80 mg/kg showed the trend of enhancing sputum secreting, but had no effect on ammonia-induced cough and xylene-induced ear edema. " 06/28/2019 - "To observe the effects relieving cough, expelling phlegm and lessening the ear swelling of BFC extracts and BFP extracts through ammonia liquor inducing cough, phenol red apophlegmating in mice and the xylene-induced auricular swelling of mouse, respectively. " 10/28/2014 - "Antitussive evaluations were carried out with ammonia liquor induced mice cough; expectorant effects were tested with phenol red secretion experiments in mice; anti-inflammatory effects were assessed by murine model of xylene induced ear edema in mice. "

Related Drugs and Biologics

1.	Acetic Acid (Vinegar)
2.	Carrageenan
3.	Formaldehyde (Formol)
4.	Toluene
5.	Lipopolysaccharides
6.	Solvents
7.	Acetone
8.	Proteins (Proteins, Gene)
9.	Histamine (Histamine Dihydrochloride)
10.	Serotonin (5 Hydroxytryptamine)

Related Therapies and Procedures

1.	Therapeutics
2.	Cutaneous Administration
3.	Oral Administration
4.	Traditional Medicine (Folk Remedies)
5.	Fluid Therapy (Oral Rehydration Therapy)