|1.||Head and Neck Neoplasms (Head and Neck Cancer)
|1.||Langendijk, Johannes A: 18 articles (09/2015 - 11/2005)|
|2.||Chambers, Mark S: 11 articles (07/2015 - 09/2004)|
|3.||Eisbruch, Avraham: 11 articles (07/2012 - 01/2003)|
|4.||Vissink, Arjan: 10 articles (01/2014 - 01/2004)|
|5.||Ship, Jonathan A: 8 articles (10/2008 - 03/2002)|
|6.||Epstein, Joel B: 7 articles (09/2015 - 02/2004)|
|7.||McMillan, Anne S: 7 articles (11/2006 - 12/2003)|
|8.||Coppes, Robert P: 6 articles (09/2015 - 10/2008)|
|9.||Jensen, Siri Beier: 6 articles (06/2015 - 04/2003)|
|10.||Schilstra, Cornelis: 6 articles (11/2013 - 03/2012)|
|1.||Pilocarpine (Ocusert)FDA LinkGeneric
02/01/1995 - "It is concluded that in these studies pilocarpine produced clinically significant benefits with acceptable side effects and risks for the treatment of symptomatic postradiation xerostomia. "
02/01/1995 - "There was a significant improvement in the overall "global" condition of xerostomia associated with the use of pilocarpine in both studies. "
01/01/1995 - "In these studies, pilocarpine 5 to 10mg 3 times daily increased salivary flow and improved symptoms of xerostomia in a significantly higher percentage of patients than did placebo (54 versus 25% in one study). "
07/01/2002 - "Pilocarpine has been approved for the treatment of this condition in the chronic phase, but its use concurrent with radiation could also be beneficial for prevention or reduction of the subsequent radiation-induced xerostomia. "
01/01/1995 - "Thus, pilocarpine is an effective agent for the treatment of xerostomia, increasing salivary flow and reducing symptom severity to a significantly greater extent than placebo. "
|2.||cevimeline (Evoxac)FDA Link
01/01/2002 - "In these studies, cevimeline 30mg three times daily increased salivary flow and improved the symptoms of xerostomia in a significantly higher percentage of patients compared with placebo. "
11/19/1997 - "These results indicate that SNI-2011 may be useful in the treatment of xerostomia because of its long-lasting sialogogic action."
11/01/1994 - "These results suggest that SNI-2011 could be useful in the treatment of xerostomia in patients with Sjögren's syndrome."
01/01/2002 - " clinical efficacy of cevimeline in relieving symptoms of xerostomia, including oral dryness and difficulties in chewing, swallowing and speaking, has been demonstrated by placebo-controlled, double-blind, randomised clinical trials in the USA and Japan. "
04/01/2008 - "The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study."
|3.||Amifostine (Ethyol)FDA LinkGeneric
05/01/2006 - "In terms of xerostomia prevention, some clinical trials evaluating amifostine and intensity-modulated radiation therapy have shown positive results. "
03/01/2002 - "Furthermore, amifostine reduced the severity of late xerostomia, a side effect of RT with long-lasting consequences. "
01/01/2002 - "These data suggest that amifostine SC provided comparable protection against RT-induced acute xerostomia as amifostine intravenously."
01/01/2009 - "Amifostine versus placebo showed no statistically significant differences in the incidence of xerostomia (130 patients, two studies), the decrease of scintigraphically measured uptake of technetium-99m by salivary or submandibular glands at twelve months (80 patients, one study), and the reduction of blood pressure (130 patients, two studies). "
02/01/2007 - "The incidence of acute xerostomia was lower than reported previously with no amifostine in a controlled study; rates of acute xerostomia were similar between s.c. "
04/01/2005 - "The authors investigated the efficacy of different artificial saliva compounds in patients with postirradiation xerostomia. "
11/01/2009 - "A literature search was conducted during July to September 2008 in PubMed, using the query terms "saliva substitute", "saliva substitute and xerostomia", "artificial saliva", and "artificial saliva and xerostomia"; for clinical studies, only studies in patients suffering from radiation-induced xerostomia have been included in the review. "
01/01/2014 - "In conclusion, for the development of ideal artificial saliva, research based on the understanding of pathophysiology of xerostomia and knowledge about rheological and biological functions of human saliva are necessary. "
01/01/2014 - "Understanding of xerostomia and strategies for the development of artificial saliva."
01/01/2014 - "Due to the reduced capacity of salivary glands to regenerate, hyposalivation is treated by substitution with artificial saliva, rather than through functional restoration of the glands. "
03/01/2010 - "Application of the mucoadhesive tablets resulted in a significant reduction in the sensation of the mouth dryness (P = .016) compared to Biotène. "
05/01/2004 - "Administration of 5-mg pilocarpine hydrochloride tablets three times daily significantly improved salivary production and clinical symptomatology secondary to radiation-induced hyposalivation with minimal side-effects. "
01/01/2001 - "Clinical studies with pilocarpine (Salagen) tablets in the United States have demonstrated significant subjective and objective benefit for xerostomia and related oral symptoms at doses of 20 mg/day or more. "
03/01/1996 - "A multicenter maintenance study of oral pilocarpine tablets for radiation-induced xerostomia."
03/15/1987 - "Pilocarpine and placebo tablets were administered for 90 day periods in a double-blind, sequential crossover trial to 12 patients with postradiation xerostomia. "
01/01/2006 - "The aim of this series of studies on rheological, sensory, and mucoadhesive properties was to evaluate the potential of using a combined polymer system to more closely represent the adaptive nature of saliva, while providing long lasting relief from the symptoms of xerostomia. "
06/01/1998 - "Efficacy of a synthetic polymer saliva substitute in reducing oral complaints of patients suffering from irradiation-induced xerostomia."
01/01/2006 - "It is clear from the many clinical studies carried out on currently available saliva substitutes, that the main factors limiting the success of polymers in treating xerostomia is their short duration of action and/or their lack of acceptability by users. "
01/01/2006 - "Evaluation of a combined polymer system for use in relieving the symptoms of xerostomia."
01/01/2006 - "The essential role of polymers in saliva substitutes is to provide lubrication, hydration, and protection of the oral mucosa, providing symptomatic relief to sufferers of xerostomia. "
12/01/2007 - "The results of this study suggest that the BioXtra dry mouth care system is effective in reducing the symptoms of radiation-induced xerostomia and improving the quality of life of xerostomia patients, even if a proportion of the benefit is due to a placebo effect. "
01/01/2012 - "We tried to design a clinical research on BIOXTRA efficacy for treating xerostomia. "
01/01/2012 - "There are different types of commercial synthetic saliva such as BIOXTRA, but until now, no one can effectively relieve xerostomia. "
12/01/2007 - "The BioXtra products significantly diminished the most common symptoms of xerostomia. "
09/01/2005 - "This study assessed the efficacy of the Bioxtra (BX) and Biotène Oralbalance (OB) systems in the treatment of post-radiotherapy xerostomia. "
09/01/1998 - "The purpose of this study was to evaluate the effectiveness of a custom vinyl tray-applied fluoride gel to control cariogenic bacteria in a group experiencing hyposalivation because of radiation treatment. "
11/01/2013 - "In multiple logistic regression analysis, CA patients were at increased risk for xerostomia (OR = 22.66, p = 0.003), sleep disturbances (OR = 4.36, p = 0.04) and more frequent use of daily extra fluoride (OR = 3.58, p = 0.03). "
05/01/2013 - "Simplified methods of topical fluoride administration: effects in individuals with hyposalivation."
07/01/2012 - "For patients with hyposalivation fluorides are supportive to prevent caries lesions. "
08/01/2010 - "Besides the use of saliva substitutes, patients suffering from hyposalivation are instructed to apply fluoride products to prevent caries. "
03/01/2014 - "To our knowledge, this is the first study that demonstrated an association between genetic polymorphisms and the risk of radiation-induced late xerostomia in nasopharyngeal carcinoma patients treated with Intensity Modulation Radiated Therapy. "
03/01/2011 - "Our aim in this study was to investigate the value of the submandibular salivary gland transfer procedure in prevention of radiation-induced xerostomia in patients with nasopharyngeal carcinoma (NPC). "
11/01/2007 - "This randomized trial compared the rates of delayed xerostomia between two-dimensional radiation therapy (2DRT) and intensity-modulated radiation therapy (IMRT) in the treatment of early-stage nasopharyngeal carcinoma (NPC). "
05/01/2004 - "This study was designed to investigate the severity of xerostomia and its impact on the quality of life in patients with nasopharyngeal carcinoma after conventional radiation therapy. "
01/01/2015 - "We investigated the incidence of moderate to severe patient-reported xerostomia among nasopharyngeal carcinoma (NPC) patients treated with helical tomotherapy (HT) and identified patient- and therapy-related factors associated with acute and chronic xerostomia toxicity. "
|10.||Chewing Gum (Chewing Gums)IBA
01/01/2013 - "In the crossover trial, DTI, XI, IDWG2d, IDWG3d, VAS thirst and xerostomia score were significantly reduced by the use of chewing gum (P=0.000, 0.001, 0.009, 0.017, 0.038, 0.001). "
09/01/2011 - "The aim of the present study was to assess the effect of 3 months of regular use of sugar-free chewing gum on xerostomia, thirst, and hydration and nutritional status in HD patients. "
03/01/2005 - "The aim of the present study was to investigate the effect of chewing gum or a saliva substitute on xerostomia, thirst and IWG. "
09/01/2011 - "Regular gum chewing is known to be well tolerated by most HD patients; however, it does not lead to the alleviation of xerostomia or excessive thirst and does not reduce IWG or improve hydration status."
06/01/2005 - "Patients who complain of mouth dryness after prolonged gum chewing may have become accustomed to the larger volume of saliva present in the mouth during the gum chewing."
01/01/2007 - "Most of the xerostomia-related QOL scores improved in time after radiotherapy without altering the global QOL, which remained high. "
07/01/2012 - "Acupuncture given concurrently with radiotherapy significantly reduced xerostomia and improved quality of life."
01/01/2011 - "A xerostomia questionnaire was answered by 42 patients 41 and 90 months after radiotherapy: xerostomia at rest did not change significantly over time whereas the difficulties with speaking improved and the difficulties with eating worsened. "
09/01/1999 - "The mean values of WR were lower in the chemoradiotherapy glands than in the radiotherapy alone glands in each of cumulative dose ranges of 1-20, 21-30, and 31-60 Gy. With regard to recovery from xerostomia, the WR values at a cumulative dose range of 20 to 40 Gy were significantly lower in the not improved group (-0.418, n = 16) than in the improved group (0.245, n = 16) (p < 0.0001). "
09/01/2005 - "In conclusion, both treatments were effective in alleviating the symptoms of post-radiotherapy xerostomia, although BX achieved superiority in some of the outcomes assessed compared with OB."
|2.||Drug Therapy (Chemotherapy)
08/01/2014 - "The findings of this study confirm that IMRT associated with chemotherapy, even with moderately hypofractionated regimens, allows good disease control with better results in terms of late xerostomia, although without statistically significant differences compared to 2DRT and 3DCRT. "
12/01/2013 - "Thus, in the present study, we elucidated the potency of these herbal extracts as novel candidates for xerostomia to improve the quality of life of patients undergoing chemotherapy."
01/01/2014 - "According to these results, chemotherapy in children might result in a decreased stimulated whole saliva flow rate, hyposalivation, and, consequently, increased caries risk. "
12/01/2013 - "Since patients with xerostomia have reduced quality of life, it is urgent and important to identify nontoxic and natural agents capable of reducing the adverse effect of chemotherapy on salivary gland function. "
01/01/2012 - "Patients with associated diseases or drug therapy causing xerostomia were excluded. "
04/01/2005 - "After treatment, the QOL scores recovered without improvement in xerostomia. "
10/01/2003 - "Improvement in xerostomia symptoms was noted, with a mean increase in the visual analog scale score of 86 (p < 0.0005) and 77 (p < 0.0001) at 3 and 6 months after treatment completion, respectively. "
06/01/1982 - "From the present study, the maximum tolerance doses resulting in a 50% complication rate 5 years after treatment (TD 50/5) are estimated to be 40--65 Gy for xerostomia and 50--65 Gy for taste loss. "
07/01/2014 - "At 24 months after treatment, 13.2% of patients had grade 2 xerostomia, and none had grade 3 or 4 xerostomia. "
12/01/2013 - "Quality of life (QOL) scores deteriorate during and shortly after treatment but returned in all scales to baseline scores within 6 to 12 months, with the exception of xerostomia. "
01/01/2007 - "Oral administration of AEDs may be affected by changes associated with aging, including altered oral protective reflexes, xerostomia, thickening of the esophageal smooth muscle layer, reduced contraction velocity and duration, altered esophageal emptying rates, and enteric plexus neuron reduction. "
01/01/2006 - "Altered oral protective reflexes, xerostomia, and delayed esophageal emptying in elderly patients may complicate oral administration of some medications. "
07/01/1997 - "In patients with residual salivary function, oral administration of pilocarpine 5-10 mg three times a day is effective in increasing salivary flow and improving the symptoms of xerostomia, and this therapy should be considered as the treatment of choice. "
05/01/1999 - "Our results demonstrate that objective and subjective relief from xerostomia in cGVHD patients can be achieved with the routine oral administration of pilocarpine hydrochloride."
01/01/2009 - "The primary treatment to relieve xerostomia symptom is oral administration of pilocarpine, a parasympathomimetic agent with muscarinic action. "
|5.||Oral Hygiene (Dental Hygiene)
02/01/1991 - "Improvement in oral hygiene and relief of xerostomia might promote recolonization with normal oral flora. "
12/01/2014 - "In a randomised, evaluator-blinded, controlled trial, 60 subjects with hyposalivation (12 men and 48 women) were randomly assigned to two groups: the control group received basic oral hygiene instruction, while for the study (intervention) group, oral hygiene instruction was based on cognitive behavioural principles and motivational interviewing (MI). "
12/01/2014 - "In patients with hyposalivation, the application of oral hygiene instruction based on cognitive principles and MI offers benefits for periodontal health. "
12/01/2014 - "Effectiveness of a motivational-behavioural skills protocol for oral hygiene among patients with hyposalivation."
07/22/2014 - "A percentage of 87.8 had adequate oral hygiene, 17.3% reported bad breath and 29.6% had xerostomia. "