Lutein

A xanthophyll found in the major LIGHT-HARVESTING PROTEIN COMPLEXES of plants. Dietary lutein accumulates in the MACULA LUTEA.

Also Known As:

Lutein F; Lutein G; beta,epsilon-Carotene-3, 3'-Diol, (3R,3'R,6'S)-; beta,epsilon-Carotene-3,3'-diol, (3S,3'R,6'S)-; gamma Lutein; Lutein, gamma; beta,epsilon-Carotene-3,3'-diol, (3R,3'R,6'R)-

Networked: 1244 relevant articles (86 outcomes, 235 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Johnson, Elizabeth J: 24 articles (01/2019 - 03/2002)
2.	Bernstein, Paul S: 19 articles (01/2021 - 10/2002)
3.	Chew, Emily Y: 17 articles (01/2022 - 12/2006)
4.	Ma, Le: 15 articles (01/2019 - 01/2009)
5.	Willett, Walter C: 11 articles (01/2021 - 07/2004)
6.	Lin, Xiao-Ming: 11 articles (03/2015 - 01/2009)
7.	Huang, Yang-Mu: 10 articles (03/2015 - 01/2009)
8.	Xu, Xian-Rong: 10 articles (03/2015 - 01/2009)
9.	Zou, Zhi-Yong: 10 articles (03/2015 - 01/2009)
10.	Fernandez, Maria Luz: 9 articles (06/2022 - 01/2006)

Related Diseases

1.	Macular Degeneration (Age-Related Maculopathy) 10/01/2008 - "Metabolites of lutein are highly concentrated in the human macula and are known to provide protection against age-related macular degeneration. " 02/15/2013 - "Lutein and DHA supplementation is effective in increasing the MPOD and may aid in prevention of age related macular degeneration." 08/01/2004 - "Lutein may be protective against diseases such as age-related macular degeneration (ARMD). " 03/01/2022 - "The level and efficacy of lutein in patients with age-related macular degeneration: a comprehensive systematic review and meta-analysis." 01/01/2020 - "Effects of Lutein Supplementation in Japanese Patients with Unilateral Age-Related Macular Degeneration: The Sakai Lutein Study."
2.	Cataract (Cataracts) 01/01/2003 - "Visual function in patients with age-related cataracts who received the lutein supplements improved, suggesting that a higher intake of lutein, through lutein-rich fruit and vegetables or supplements, may have beneficial effects on the visual performance of people with age-related cataracts." 01/01/2021 - "MPOD increased after lutein supplementation in patients who had undergone cataract surgery. " 01/01/2020 - "and lutein ameliorate cataract in type 1 diabetic rats." 01/01/2019 - "Cataract severity was significantly reduced in rats treated with topical applications of lutein-loaded NPs compared to the positive control, while no significant differences were observed in rats treated with other lutein formulations including oral and topically applied free lutein." 10/01/2016 - "A plethora of literature has shown that increased lutein consumption has a close correlation with reduction in the incidence of cataract. "
3.	Inflammation (Inflammations) 12/01/2022 - "It can be concluded that 40 mg/kg lutein supplementation improved LPS-induced jejunal mucosal barrier function and tamed inflammation of yellow-feather broilers." 10/01/2019 - "The aim of the present study was to investigate whether pretreatment with lutein attenuates acute inflammation-induced sensitization of nociceptive processing in rat spinal trigeminal nucleus caudalis (SpVc) and upper cervical (C1) dorsal horn neurons, via c-Fos immunoreactivity. " 04/01/2018 - "The present study shows significant cytoprotection offered by lutein against MIA-induced oxidative stress, inflammation and apoptosis by the modulatory effect of NF-κB and Nrf2 activation." 02/28/2023 - "In contrast, lutein interventions prevented alcohol-induced alterations in liver tissue, oxidative stress and inflammation. " 06/09/2022 - "Lutein Can Alleviate Oxidative Stress, Inflammation, and Apoptosis Induced by Excessive Alcohol to Ameliorate Reproductive Damage in Male Rats."
4.	Atherosclerosis 12/01/2011 - "High serum level of lutein may be protective against early atherosclerosis: the Beijing atherosclerosis study." 06/19/2001 - "These epidemiological, in vitro, and mouse model findings support the hypothesis that increased dietary intake of lutein is protective against the development of early atherosclerosis." 11/01/2019 - "Mechanistic insights into the effect of lutein on atherosclerosis, vascular dysfunction, and related risk factors: A systematic review of in vivo, ex vivo and in vitro studies." 01/01/2016 - "We used logistic regression to examine the association between prevalent DR and energy-adjusted lutein intake by quartile (Q) using data collected from 1430 Atherosclerosis Risk in Communities Study (ARIC) participants with diabetes (n = 994 white, n = 508 black). " 03/01/2015 - "The main aim of this study was to investigate the effects of lutein on the alleviation of atherosclerosis and its molecular mechanisms involved in oxidative stress and lipid metabolism. "
5.	Eye Diseases (Eye Disease) 01/01/2020 - "Lutein, which is beneficial for eye diseases, was administered concurrently. " 01/18/2022 - "For the sake of players' eyesight, it would be useful to use lutein, which, in addition to improving vision and protecting against eye diseases, can also affect cognitive functions. " 11/01/2021 - "Inadequate intake of lutein is relevant to a higher risk of age-related eye diseases. " 06/09/2020 - "Finally, the effects of lutein consumption on the aforementioned eye diseases will be reviewed." 06/09/2020 - "Lutein Supplementation for Eye Diseases."

Related Drugs and Biologics

1.	Zeaxanthins
2.	Carotenoids (Carotene)
3.	Lycopene
4.	Antioxidants
5.	Xanthophylls
6.	beta Carotene (Betacarotene)
7.	Retinaldehyde (Retinal)
8.	Macular Pigment
9.	Ascorbic Acid (Vitamin C)
10.	Vitamin E

Related Therapies and Procedures

1.	Lenses
2.	Capsulorhexis
3.	Phacoemulsification
4.	Therapeutics
5.	Drug Therapy (Chemotherapy)