|1.||Wounds and Injuries (Trauma)
|1.||Holcomb, John B: 149 articles (01/2016 - 01/2002)|
|2.||Chaudry, Irshad H: 148 articles (11/2015 - 01/2002)|
|3.||Demetriades, Demetrios: 113 articles (11/2015 - 01/2002)|
|4.||Inaba, Kenji: 107 articles (11/2015 - 01/2006)|
|5.||Moore, Ernest E: 102 articles (01/2016 - 01/2002)|
|6.||Bland, Kirby I: 93 articles (07/2015 - 01/2002)|
|7.||Scalea, Thomas M: 81 articles (10/2015 - 06/2002)|
|8.||Choudhry, Mashkoor A: 80 articles (04/2013 - 06/2002)|
|9.||Deitch, Edwin A: 75 articles (12/2014 - 06/2002)|
|10.||Rhee, Peter: 70 articles (12/2015 - 08/2002)|
01/01/2015 - "Improved re-epithelization, reduced inflammatory infiltration and increased collagen deposition were observed in biopsies from wounds treated with ASCs, with the best result in the autologous setting. "
10/01/2001 - "These results show that the application of TGF-beta(1) treated collagen matrix is effective for preventing contraction producing so called "neodermis" in treating a delayed healing type model and may be highly beneficial for treating chronic wounds."
02/01/1981 - "The healing wounds in the glandular oxyntic part of the stomach and duodenum showed the most rapid increase in collagen concentration in the incision line and 40 days postoperatively both had collagen concentrations significantly greater than those of intact tissues. "
01/01/2012 - "The gradual pbFGF release revealed significantly higher wound recovery rate with improved vascularization, enhanced collagen deposition and maturation, complete re-epithelialization and formation of skin appendages. "
01/01/2011 - "Wound healing study revealed significant reduction in wound size and mean epithelisation time, and higher collagen synthesis in the 2% extract-treated group compared to the vehicle group. "
|2.||Anti-Bacterial Agents (Antibiotics)IBA
09/01/1982 - "Primary repair of concomitant injuries, use of perioperative prophylactic antibiotics, and rigid immobilization for a short period followed by active mobilization will yield the best results."
02/01/1989 - "The basic principles of the pathology, physiology, diagnosis, and management of nonpenetrating chest trauma evolved to a significant degree before World War II. The advances in the past 40 years include more frequent use of endotracheal intubation, improved ventilatory assistance, better control of blood volume, antibiotics, the clinical application of blood-gas studies, diagnostic imaging, and specialized nursing and monitoring in intensive care units. "
02/01/2009 - "She has been successfully treated with antibiotics, i.v. biophosphonates and intensive local wound care. "
02/01/2005 - "Despite this lack of evidence, antibiotics are frequently a feature of the management of chronic wounds and these patients receive significantly more antibiotic prescriptions (both systemic and topical) than age and sex-matched patients. "
02/01/1995 - "Of the 15 factors studied, only intravenous antibiotics significantly decreased the incidence of positive anterior chamber cultures in eyes treated before wound repair compared with eyes not receiving such therapy (P = .002). "
01/21/2009 - "This requires the ability to determine the efficacy of silver directly within the wound environment; an extremely complicated task that is difficult using classical (plate counting) microbiological assays because these cannot be conducted in situ. "
07/01/2014 - "crenulata was found to be very effective in wound repair and encourages harnessing the potentials of the plant biomolecules loaded silver nanoparticle in the treatment of tropical diseases including wound healing. "
09/01/2012 - "Although there was no observed difference in the number of women requiring additional wound care visits, the significantly greater number of comorbidities noted in the silver-impregnated dressing group should have theoretically placed them at increased risk for SSIs and additional postoperative wound care visits, suggesting that silver-impregnated dressings may have more of a protective effect than is appreciated in this study. "
05/01/2014 - "Furthermore, as compared to commercial wound gel Silver-Sept™, DispersinB(®)-KSL-W peptide-based wound gel was significantly more effective in inhibiting the biofilm-embedded MRSA, S. "
10/01/2013 - "In contrast, silver dressings improved healing in diabetic wounds despite no effect on bioburden, suggesting silver may have beneficial effects in addition to its antimicrobial properties."
03/01/2013 - "Hyperbaric oxygen has proven to be a useful treatment for chronic wounds. "
08/01/2000 - "The efficacy of adjunctive hyperbaric oxygen in the treatment of lower extremity problem wounds in diabetic patients seems to be proven. "
02/01/1996 - "Initially after trauma, a high extraction of oxygen was found, followed by a marked decrease in the subsequent days, presumably reflecting an early, decreased cerebral blood flow and a hyperaemic flow pattern thereafter. "
08/01/2015 - "NPT has been shown to be beneficial in increasing blood flow, thanks to feedback resulting from the decreased oxygen pressure, angiogenesis and reduction of the wound surface area. "
01/01/2013 - "Provision of supplemental oxygen to maintain soft tissue viability acutely following trauma in which vascularization has been compromised would be beneficial for limb and tissue salvage. "
04/25/1999 - "According their experiences of new treatment method with definitive one-stage management of complex craniofacial injuries they decreased the incidence of postoperative complications, the time of hospitalisations obtained optimal functional and cosmetic results."
03/01/1997 - "The skin-stretching device produced excellent functional and cosmetic wound closure results and eliminated the need for additional operative procedures."
12/01/1982 - "The incision improves visualization of the medial, posterior, and lateral aspects of the foot and ankle, while at the same time resulting in excellent healing of the wound and an improved cosmetic appearance compared with the more commonly used vertical incisions."
06/01/2013 - "Based on our results, we conclude that Prineo™ is a safe and effective substitute for superficial skin closure, with good cosmetic results and no increase in wound complications. "
07/01/2011 - "Minimal trauma, short duration of the operation, good cosmetic results, uncomplicated course of postoperative period witnesses the efficacy of laparoscopic adhesiolysis in the treatment of an acute adhesive ISI."
|6.||Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric
01/01/2001 - "To assess the analgesic efficacy of patient-controlled bupivacaine wound instillation, 50 patients undergoing major intraabdominal surgery were enrolled into this prospective, placebo-controlled, double-blinded study. "
01/01/1999 - "Intraperitoneal bupivacaine is as effective as wound infiltration. "
08/01/1994 - "The analgesic efficacy of continuous intermuscular wound infusion with 0.25% bupivacaine was studied in 10 patients (four men, six women), with a mean age of 47.5 years (range 25-71) and a mean weight of 71.2 kg (range 44-99), after renal surgery in a single-blind randomized trial. "
04/01/1993 - "This study compares the efficacy of wound instillation with 0.25% bupivacaine (n = 20), caudal block with 0.25% bupivacaine (n = 35), and a control group (n = 15). "
05/01/1995 - "To compare the efficacy of preincision wound infiltration with bupivacaine to wound infiltration at the end of the operation. "
01/01/2004 - "This paper examines reports in the literature on the outcomes of studies into the efficacy of this group of dressings, discusses the types of wounds that are most suitable for hydrogel application and poses questions that merit further investigation."
01/01/2013 - "Meta analysis of three studies comparing hydrogel dressings with basic wound contract dressings found significantly greater healing with hydrogel: risk ratio (RR) 1.80, 95% confidence interval (CI) 1.27 to 2.56. "
05/01/2011 - "The results of this study suggest significant clinical promise for our hydrogel-delivery vehicle in the treatment of wounds."
01/01/2011 - "Meta analysis of three studies comparing hydrogel dressings with basic wound contract dressings found significantly greater healing with hydrogel: risk ratio (RR) 1.80, 95% confidence interval (CI) 1.27 to 2.56. "
01/01/2015 - "After hydrogel association with BMSCs treated the wound, significantly greater wound contraction was observed in the hydrogel + BMSCs group. "
|8.||Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/01/1993 - "Growth factors are extremely potent biologic agents that show promise in accelerating wound repair in both animal and human studies. "
01/01/2010 - "However, the exogenous application of growth factors to chronic wounds has not proven to be effective in healing them. "
06/01/1990 - "The animals treated with growth factors also had significantly greater wound closure at 21 days than those treated with the vehicle. "
04/01/2011 - "These results suggest that simple uniform distributions of growth factors immobilized to an extracellular matrix material may be as effective in directing cell migration into a wound site as more complex patterns with concentration gradients."
01/01/2015 - "Large doses of recombinant growth factors formulated in solution form directly injected into the body is usual clinical practice in treating second-degree scald injuries, with promising results, but this approach creates side effects; furthermore, it may not allow appropriate levels of the factor to be sensed by the target injured tissue/organ in the specific time frame, owing to complications arising from regeneration. "
|9.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/01/2008 - "There was a statistically significant reduction in wound strength in the anti-VEGF mAb treated animals on Day 8 as compared to saline in Study 2. Statistical evaluation of wound strength between saline treated animals and the anti-VEGF mAb treated animals showed a significant reduction in wound strength in the anti-VEGF mAb treatment group on Day 8 (Fig. "
10/01/2013 - "The early application of TNF-α plus IFN-γ-stimulated autologous Mo/Mp to diabetic wounds significantly improved the delayed wound healing through the stimulation of angiogenesis and re-epithelization, as well as restoring the defect in VEGF expression. "
01/01/2013 - "At day 7, both anti-vascular endothelial growth factor (anti-VEGF) agents had significantly suppressed MNV scores and exerted a significant reduction of cutaneous wound tensile strength compared with saline controls. "
05/01/2006 - "Further studies are underway to assess whether exogenous VEGF is effective in other liver injuries."
03/01/2004 - "Further studies will demonstrate if exogenous VEGF can be effective in other liver injuries."
|10.||Fibrin Tissue Adhesive (Fibrin Sealant)IBA
09/01/2012 - "In conclusion, suspension of cultured autologous oral keratinocytes in fibrin glue significantly accelerates oral wound healing in the rabbit model and could be beneficial in the treatment of oral wounds in patients."
05/15/1989 - "In order to compare the results obtained in terminoterminal and terminolateral intestinal anastomoses using fibrin glue, both fibrin glue and the tissucol KIT were used on a group of rats: comparison of the wounds so treated revealed that both products gave good results. "
04/01/1986 - "However, comparisons of the curve magnitudes indicated that there was a significantly greater reduction in wound size in the fibrin sealant treated group. "
05/01/1986 - "This study evaluated Fibrin Sealant (FS), a two-component biologic adhesive that is effective in establishing hemostasis, in 27 experimentally produced splenic injuries in five adult mongrel dogs. "
02/01/1991 - "To prevent postoperative cerebrospinal fluid leakage, the following procedures were very useful; 'blind sack closure' of the external auditory canal, careful closure of the Eustachian tube, use of the pedicled muscle flap from the temporal and the sternocleidomastoid muscle, use of fibrin glue at the time of the wound closure, and placement of preventive spinal drainage. "
05/01/2014 - "Sensory nerve grafts, the clinical "gold standard", and most alternative techniques for bridging nerve gaps, promote reliable axon regeneration only across nerve gaps <2cm in length, and with few axons regenerating when nerve repairs are performed >2 months post-trauma or for patients >20 years of age. "
02/01/2014 - "Tissue-engineered dermis (TED) is thought to be the best treatment for skin defect wounds; however, lack of vascular structures in these products can cause slow vascularization or even transplant failure. "
12/01/2012 - "Tissue grafts and vascularised flaps (either pedicled or free) bring healthy tissue to a compromised wound for optimal healing and are the current gold standard for the repair of such defects, but disadvantages are their limited availability, the difficulty of shaping the flap to fit the defect and, most importantly, donor site morbidity. "
02/01/2001 - "The improved mechanical properties and enhanced healing of the highly porous filament-wound Lycra scaffold graft coated with hydrophilic biodegradable PELA has the potential of being a highly effective small caliber prosthetic graft."
07/01/2000 - "When selected as the best alternative for wound closure, autologous skin grafts are commonly considered the gold standard. "
02/01/2005 - "It is most important and un-dispensable to have an early and exact diagnosis and consistent therapy: immediate radical surgical debridement, open wounds, antibiotic treatment, immobilisation and early mobilisation are necessary to have good results."
04/01/1995 - "The results suggest that all products were effective in debridement of nonviable tissue, but the best overall results were obtained with the 8 x 8 mesh product which more effectively debrided the wounds than the nonwoven sponges with the smaller apertures. "
02/01/2009 - "Accurate wound debridement is important, and while many methods exist, surgical debridement is currently the gold standard with material costs at approximately pound 140. "
06/01/2001 - "Because bone biopsy results seem to aid in tailoring antibiotic therapy in almost half the cases when bone is sampled during wound debridement surgery, this technique may be very helpful in certain cases and should be regularly undertaken when these procedures are carried out."
01/01/1988 - "Its therapeutic efficacy is evident and the dressing enhances the wound debridement and accelerates the re-epithelialization, with complete healing in 8.5 days on the average. "
04/01/2003 - "To use an old but true adage, the best treatment for trauma is not in the resuscitation bay, not in the operating room, the best treatment is in our own communities and neighborhoods."
09/01/1993 - "Dramatically improved diagnostic capabilities, use of open surgical techniques, improved rigid fixation devices, advances in techniques of resuscitation, and more focused surgical training have markedly improved the care of the facial trauma patient. "
11/01/1989 - "Trauma nursing documentation has dramatically improved at our institution with the implementation of the trauma resuscitation record. "
01/01/2015 - "Key advancements in which progress has led to improved outcomes for injured personnel are highlighted--the control and treatment of blood loss, wound care, and the prevention and management of organ failure with optimal resuscitation. "
01/01/2011 - "This method of resuscitation is proven to be effective in evaluating the effects of HS and trauma."
09/01/2010 - "Biocompatible and biodegradable wound sealants hold much promise in eventually replacing sutures in most surgical procedures."
07/01/2010 - "Therefore, suture closure seems to be the best option for secondary closure of superficial wound dehiscence.However"
01/01/1984 - "Acute suture of isolated anterior cruciate ligament injuries afforded the best results in this series and is recommended."
01/01/2013 - "It is important to highlight how the suture repairs have evolved and improved but also review how they may contribute to their own trauma. "
07/01/2001 - "Undermining and pulley sutures are very helpful in bringing together wound edges of certain large openings. "
|5.||Negative-Pressure Wound Therapy
02/01/2007 - "Topical negative pressure therapy helped to achieve complete wound closure in 14 patients (54%), and there was a mean reduction in wound surface area from 52.2 cm2 (range 4-150) to 26.8 cm2 (0-120). "
10/01/2005 - "The vacuum-assisted closure system has proven to be effective and safe in the treatment of a variety of wound types. "
08/01/2003 - "Vacuum-assisted closure (VAC) therapy has proven cost efficient, safe, and effective as a treatment modality in wound care. "
01/01/2004 - "In conclusion, this study shows a positive effect of vacuum-assisted closure therapy on wound healing, expressed as a significant reduction of wound surface area. "
07/01/2015 - "Topical negative pressure therapy is an alternative treatment for complex wounds that consists of the direct application of sub-atmospheric pressure, obtaining a number of effects that are beneficial for tissues, promoting the healing of both acute and chronic wounds and complementing surgical procedures. "