|1.||Wounds and Injuries (Trauma)
|1.||Ingemansson, Richard: 10 articles (01/2014 - 05/2002)|
|2.||Sessler, Daniel I: 8 articles (08/2012 - 06/2003)|
|3.||Herndon, David N: 8 articles (01/2012 - 09/2006)|
|4.||Athanasiou, Thanos: 8 articles (02/2010 - 12/2003)|
|5.||Fleck, Tatjana: 7 articles (06/2014 - 04/2006)|
|6.||Sjögren, Johan: 7 articles (09/2012 - 12/2003)|
|7.||Cui, Weihua: 7 articles (09/2010 - 01/2005)|
|8.||De Feo, Marisa: 6 articles (10/2015 - 02/2003)|
|9.||Guyton, Robert A: 6 articles (09/2015 - 03/2005)|
|10.||Hamblin, Michael R: 6 articles (09/2014 - 01/2002)|
|1.||Anti-Bacterial Agents (Antibiotics)IBA
06/01/1997 - "Properly administered antibiotics are successful in minimizing postoperative subcutaneous wound infection secondary to perioperative bacterial contamination at the surgical site and are effective in most clean-contaminated surgical procedures. "
03/01/1988 - "The administration of antibiotics significantly reduced the frequency of wound infection in clean surgical procedures performed by senior veterinary students (p less than 0.05), but not in clean elective procedures performed by faculty or resident surgeons that required 90 minutes or less to complete. "
01/01/1985 - "Because of the significant reduction of abdominal wound infections which could be achieved in treating patients (X2 = 6,56; p less than 0,05) with antibiotics, these medicaments should be given in emergency bowel surgery with a further prospective controlled study being not necessary."
08/01/2014 - "Complication rates are low and relate largely to localised wound infections, treated successfully with antibiotics. "
04/01/2013 - "One child developed signs of wound infection and was treated successfully with antibiotics for 5 days. "
|2.||Metronidazole (Metric)FDA LinkGeneric
01/01/1983 - "A second trial revealed that intravenous metronidazole administered 1 hour before and at 8 and 16 hours after the operation provided similar protection against wound infection. "
08/01/1995 - "To compare the efficacy of rectal and intravenous metronidazole in the prevention of anaerobic wound infections after appendicectomy. "
06/01/1986 - "The study was prematurely terminated because of the high rate of wound infections in the metronidazole group and the exclusive selecting of aerobic pathogens."
06/01/1979 - "A double-blind trial of a single intravenous dose of metronidazole as prophylaxis against wound infection following appendicectomy."
01/01/2006 - "Wound infection after metronidazole infiltration."
|3.||Cefoxitin (Cefoxitin Sodium)FDA LinkGeneric
03/01/1981 - "The study shows that even a very short peroperative course of Cefoxitin is highly effective in reducing postoperative abdominal wound infections after elective colorectal surgery."
08/01/1982 - "A significant reduction in wound infection was evident in the cefoxitin-treated group (4.4 per cent) when compared with controls (16.7 per cent) (chi 2 = 6; P = 0.02). "
02/01/2001 - "Eleven women (4.6%) in the placebo group and eight (3.4%) in the cefoxitin group had microbiological evidence of wound infection. "
02/01/2001 - "Wound infection was the most common complication occurring in 13.3% and 12.5% of women in the placebo and cefoxitin groups, respectively. "
02/01/1994 - "Wound infection occurred in three patients, 2.4% of the cefoxitin group and in five patients (4%) of the second group (with no significant difference). "
|4.||Cefazolin (Ancef)FDA LinkGeneric
01/01/1992 - "Although cefazolin prophylaxis has proven efficacy in vascular surgery, Staphylococcus aureus wound infections are still an important postoperative complication. "
01/01/1991 - "In conclusion, a single preoperative dose of 1 g cefazolin proved to be effective for reducing the wound infection rate in non-cardiac thoracic surgery."
07/01/2011 - "We conducted a prospective, randomized, double-blind, placebo-controlled trial comparing wound infection rates in 404 patients (203 received prophylactic cefazolin, 201 received a placebo) undergoing TIVAD insertion. "
12/01/2000 - "Deep wound infections of the leg were more common in the cefazolin group. "
09/01/1998 - "Synergism between poly-(1-6)-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyranose glucan and cefazolin in prophylaxis of staphylococcal wound infection in a guinea pig model."
|5.||Povidone-Iodine (Betadine)FDA LinkGeneric
11/01/2013 - "There was a reduced incidence of groin wound infections in those randomized to Betadine (3 versus 1), but this was not statistically significant (P = 0.4). "
01/01/2006 - "Applying PVP-I was effective in eliminating skin contamination, as cultures became negative in all cases after applying PVP-I. However, this study could not demonstrate the reduction of wound infection or SSI in the group with PVP-I, possibly because the number of cases in this study was too small to make a difference. "
08/01/2005 - "The aim of this study was to evaluate the efficacy of dilute betadine solution in the prevention of wound infection after spinal surgery. "
08/01/2005 - "Our report is the first prospective, single-blinded, randomized study to evaluate the clinical effectiveness of dilute betadine solution irrigation for prevention of wound infection following spinal surgery. "
06/01/2002 - "The purpose of this study was to assess the influence of povidone-iodine mediastinal irrigation used for the treatment of deep sternal wound infection (DSWI) on thyroid function. "
|6.||Gentamicins (Gentamicin)FDA LinkGeneric
07/01/1976 - "Despire poor bile levels, gentamicin was associated with a significant reduction of wound infection from 22% to 6% and septicaemia from 14% to 2% compared with controls. "
09/01/2002 - "The objective of this study was to characterize the relationship between gentamicin concentrations during surgery and the development of wound infection following colorectal operations. "
11/01/2015 - "Local Application of Gentamicin in the Prophylaxis of Perineal Wound Infection After Abdominoperineal Resection: A Systematic Review."
12/01/2012 - "Incidence of sternal wound infection after reexploration in the intensive care unit and the use of local gentamycin."
09/01/2007 - "Prevention of sternal wound infections with locally administered gentamicin."
|7.||Clindamycin (Cleocin)FDA LinkGeneric
03/01/1979 - "Clindamycin produced a significant reduction in the overall rate of wound infection from 33 per cent in the controls to 17 per cent. "
12/01/1986 - "Perioperative clindamycin administration was not fully effective in preventing wound infection following cardiac surgery at our hospital, thus providing indirect evidence for the efficacy of prophylaxis with cephalosporin-containing regimens. "
03/01/1980 - "These results support the clinical use of clindamycin for the prevention of Bacteroides wound infection."
07/01/2003 - "Short-course clindamycin is as effective as long-course clindamycin in preventing wound infections after free-flap surgery for head and neck ablative defects."
07/01/2003 - "This prospective clinical trial compared short-course and long-course clindamycin prophylaxis for wound infection in patients with head and neck cancer undergoing free-flap reconstruction. "
|8.||Mupirocin (Bactroban)FDA LinkGeneric
04/01/2010 - "Prophylactic intranasal mupirocin is safe, inexpensive and effective in reducing the overall sternal wound infection after open-heart surgery. "
02/01/2008 - "Topical mupirocin application was effective against crush wound infections inoculated with S. "
10/01/1985 - "The efficacy of topically-applied mupirocin was evaluated against an experimental surgical staphylococcal wound infection in the guinea-pig. "
07/01/2007 - "The purpose of this study was to investigate the mupirocin resistance in MRSA strains isolated from wound infections of in- and out-patients of two distinct hospitals located in Ankara and Istanbul. "
05/01/2001 - "This study was designed to determine whether decreasing nasal bacterial colonization by applying Mupirocin (MPN) intranasally decreases sternal wound infections. "
|9.||Cefuroxime (Zinacef)FDA LinkGeneric
10/01/2015 - "Those receiving cefuroxime showed significantly lower incidence of wound infections (P = 0.034; risk decreased by the factor 2.88). "
01/01/2012 - "Plain radiographs showed a non-union of the tibia fracture, and microbiological analysis confirmed a wound infection with cefuroxime-sensitive Staphylococcus aureus. "
04/01/2001 - "These preliminary results of continuous infusion of cefuroxime 3 g/d for prophylaxis of sternal wound infections in CABG patients indicate that serum concentrations are highly variable, but reliably above the minimum inhibitory concentration for the common anticipated pathogens in this setting. "
01/01/1996 - "Cefuroxime is a second-generation cephalosporin with in vitro activity against the organisms that are commonly associated with neurosurgical wound infections. "
12/01/1994 - "It is concluded that in coronary artery bypass grafting a single dose of cefuroxime is as effective as a three-day course in the prevention of wound infection."
02/01/1988 - "Teicoplanin prophylaxis resulted in a significantly greater number of sternal wound infections (P less than 0.01), due to Gram-positive bacteria. "
01/01/2008 - "Comparative efficacy of topical versus systemic teicoplanin in experimental model of wound infections."
01/01/1997 - "The overall early wound infection rates (within 3 months) in these studies were 1.1% for teicoplanin and 1.7% for the comparator cephalosporin. "
01/01/1992 - "This is an ongoing study designed to evaluate the role of teicoplanin in the therapy of sternal wound infections following cardiac surgery caused by Gram-positive microorganisms. "
09/01/2005 - "Teicoplanin decreased the number of colony-forming units of MRSA, and prevents wound infection in this MRSA wound infection model."
10/02/1999 - "After wound infections that required no or only local treatment were excluded from the analysis, antibiotic prophylaxis remained highly effective in reducing clinically important wound infections (1/41 (2%) v 11/43 (26%), P<0.01) and non-wound infections (2 (5%) v 9 (21%), P<0.05). "
04/01/1996 - "As previous work has shown, antibiotic prophylaxis is highly effective in lowering wound infection rates in colorectal surgery. "
08/01/1993 - "As has been proved before, antibiotic prophylaxis is highly effective in lowering wound infection rates in colorectal surgery. "
10/01/2010 - "Single dose antibiotic prophylaxis is as effective as 3-dose therapy in clean and clean contaminated procedures to prevent wound infection and is cost-effective."
04/01/2009 - "In particular, perhaps a sensible philosophy would be to assume that antibiotic prophylaxis is effective in reducing the risk of wound infection for all types of surgery, even ones where no clinical trial data exists and make exceptions to this rule if, for certain types of surgery, it can be proved to the contrary."
02/01/1998 - "The case of MW is extreme; most patients with a sternal wound infection can be successfully treated with antibiotic therapy and debridement. "
01/01/2011 - "Aggressive sternal debridement followed by VAC therapy and secondary closure with an omental-muscle flap is effective for deep sternal wound infection. "
01/01/2014 - "Superficial wound infection occurred in 3 cases, and was cured after debridement; the other incisions healed by first intention without complications. "
03/20/2010 - "Complications occurred in two patients: one had a transient weakness of the left side lower extremity and the symptom improved spontaneously without further treatment within one month; the other patient suffered a deep wound infection three weeks after the operation, and recovered well by additional debridement, continuous perfusion and drainage. "
01/01/2009 - "Several studies have evaluated the risk factors for the development of a deep sternal wound infection, but the factors predicting survival after debridement and muscle flap advancement are not well known. "
04/01/2012 - "If not effectively treated, groin wound infections following lower extremity revascularization (LER) may result in graft or limb loss. "
02/01/1981 - "Intraoperative antibiotic coverage has been a safe and effective measure for preventing primary transplant wound infections."
09/01/2015 - "Peripheral vascular surgery may be complicated by wound infection and potential graft exposure in the groin area. "
07/01/2015 - "There was neither bacterial sternal wound infection nor sternal instability in the heart transplant group. "
07/01/2015 - "There is a wide spread of sternal wound infection incidence in transplant patients ranging from 4% to 40%. "
01/01/2008 - "There is good evidence from three trials that open mesh repair is superior to suture repair in terms of recurrences, but inferior when considering wound infection. "
01/01/2013 - "Following the training intervention, group A clusters had a significant reduction in mean percentages of women reporting perineal wound infections and of women needing sutures removed. "
01/01/1991 - "The use of atraumatic needles and modern, synthetic suture materials have decreased the incidence of wound infections significantly. "
09/01/2011 - "Wound infections were significantly fewer in the staples group compared with the sutures group(s) (12 studies, 1529 patients; odds ratio, 2.06; 95% CI, 1.20 to 3.51). "
09/01/2011 - "The current study set out to evaluate the effectiveness of such sutures against the development of sternal wound infections after cardiac surgery. "
|5.||Negative-Pressure Wound Therapy
03/01/2013 - "In this clinical study, Prevena negative pressure dressing significantly decreased the incidence of groin wound infection in patients after vascular surgery."
06/01/2015 - "Negative pressure wound therapy (NPWT) has been reported to be useful in the treatment of severe wound infections. "
02/01/2011 - "Negative-pressure wound therapy (NPWT) has been used for the treatment of deep sternal wound infection (DSWI) with promising results. "
02/01/2013 - "Previous work has demonstrated the efficacy of vacuum-assisted closure (VAC) in the treatment of poststernotomy local wound infections, compared to historical treatment protocol. "
06/01/2015 - "It was demonstrated in previous prospective and randomized studies that negative pressure wound therapy (NPWT) reduced wound infection and other complications in clean, closed surgical incisions. "