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Wolfram Syndrome (Syndrome, Wolfram)

A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.
Also Known As:
Syndrome, Wolfram; Diabetes Insipidus and Mellitus with Optic Atrophy and Deafness; DIDMOAD; DIDMOAD Syndrome
Networked: 119 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Wolfram Syndrome (Syndrome, Wolfram)
2. Diabetes Insipidus
3. Mood Disorders (Mood Disorder)
4. Anemia
5. Low Tension Glaucoma

Experts

1. Zatyka, Malgorzata: 4 articles (02/2015 - 07/2006)
2. Oka, Yoshitomo: 4 articles (06/2009 - 07/2005)
3. Tanizawa, Yukio: 4 articles (06/2009 - 06/2003)
4. Barrett, Timothy G: 3 articles (02/2015 - 01/2008)
5. Urano, Fumihiko: 3 articles (12/2014 - 10/2012)
6. Agranat, Lily: 2 articles (06/2015 - 01/2013)
7. Lipper, Colin H: 2 articles (06/2015 - 01/2013)
8. Nechushtai, Rachel: 2 articles (06/2015 - 01/2013)
9. Tamir, Sagi: 2 articles (06/2015 - 01/2013)
10. Mittler, Ron: 2 articles (06/2015 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Wolfram Syndrome:
1. idebenoneIBA
2. TungstenIBA
3. Mitochondrial DNA (mtDNA)IBA
4. AutoantibodiesIBA
5. Insulin (Novolin)FDA Link
6. Thiamine (Aneurin)FDA Link
7. Vasopressins (Vasopressin)IBA
8. Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
9. TransferasesIBA
10. Growth Hormone (Somatotropin)IBA

Therapies and Procedures

1. Pancreas Transplantation
2. Kidney Transplantation
3. Vitrectomy
4. Light Coagulation