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Wolfram Syndrome (Syndrome, Wolfram)

A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.
Also Known As:
Syndrome, Wolfram; DIDMOADUD; Diabetes Insipidus and Mellitus with Optic Atrophy and Deafness; Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness; Wolfram Syndrome 1; DIDMOAD; DIDMOAD Syndrome
Networked: 230 relevant articles (7 outcomes, 23 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Disease Progression
2. Rare Diseases (Rare Disease)
3. Wolfram Syndrome (Syndrome, Wolfram)
4. Diabetes Insipidus
5. Type 1 Diabetes Mellitus (Autoimmune Diabetes)

Experts

1. Urano, Fumihiko: 16 articles (01/2022 - 10/2012)
2. Plaas, Mario: 10 articles (11/2021 - 08/2008)
3. Vasar, Eero: 10 articles (11/2021 - 08/2008)
4. Hershey, Tamara: 9 articles (01/2022 - 04/2013)
5. Marshall, Bess A: 7 articles (01/2022 - 04/2013)
6. Zatyka, Malgorzata: 6 articles (01/2022 - 07/2006)
7. Reimets, Riin: 6 articles (11/2021 - 08/2015)
8. Terasmaa, Anton: 6 articles (11/2021 - 01/2017)
9. Abreu, Damien: 6 articles (01/2021 - 01/2019)
10. Borowiec, Maciej: 6 articles (11/2020 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Wolfram Syndrome:
1. Glucagon-Like Peptide-1 ReceptorIBA
2. Exenatide (Byetta)FDA Link
3. Retinaldehyde (Retinal)IBA
4. C-PeptideIBA
5. LiraglutideFDA Link
6. Dantrolene (Dantrium)FDA LinkGeneric
7. Glipizide (Glucotrol)FDA LinkGeneric
8. Glucagon-Like Peptide-1 Receptor AgonistsIBA
9. Insulin SecretagoguesIBA
10. SodiumIBA

Therapies and Procedures

1. Therapeutics
2. Glycemic Control
3. Immunotherapy
4. Pancreas Transplantation
5. Kidney Transplantation