Whooping Cough (Pertussis)

09/22/2015 - "Several observational studies provide evidence that acellular pertussis vaccines (aP) are less protective against pertussis disease than highly effective whole-cell pertussis vaccines (wP), however, concerns have been raised that some of these findings may be confounded by age. "
01/01/1997 - "Vaccine efficacy of the most efficacious acellular pertussis vaccines in the three recent placebo-controlled clinical trials, when estimated using the primary clinical case criterion, does not change substantially with the inclusion of serological confirmation in addition to culture confirmation. "
01/01/2019 - "Most women who did not receive Tdap vaccine had a missed vaccination opportunity during pregnancy, indicating potential for much higher vaccination coverage and consequent infant protection against pertussis."
01/01/2018 - "The introduction of a whole-cell vaccine against Bordetella pertussis, the causative agent of whooping cough, dramatically reduced disease incidence. "
01/01/2017 - "Understanding how this disease has resurged in a highly vaccinated population is crucial for the design of improved vaccines against pertussis."

01/01/2019 - "Whole-cell pertussis vaccine (wP) has been imperative and highly effective in preventing childhood deaths due to pertussis. "
12/01/2006 - "Administering all 5 doses of pertussis vaccine and the fifth dose at age 5 years with at least 36 months between the fourth and fifth doses provided the best protection against pertussis among children and adolescents in this outbreak."
07/15/2002 - "Thus, even after partial vaccination, acellular pertussis vaccine is highly effective in preventing hospitalizations for pertussis."
01/01/1991 - "These findings suggest that, since its introduction, the whole-cell pertussis vaccine produced in South Africa has been highly effective in controlling whooping cough. "
05/01/1985 - "The incidence of pertussis has been dramatically reduced in many areas of the world over the past 25 years by the use of pertussis vaccine. "

08/01/2014 - "The acellular pertussis antigens have proven efficacy and real-world effectiveness. "
06/29/2012 - "Immunogenicity against pertussis antigen was significantly greater in the interchangeable vaccinated group compared to the control group, and 57% of the interchangeable vaccinated subjects achieved high levels of protective immunity (45.2 ± 21.5 E U/mL). "
11/01/2009 - "pertussis-derived antigens, confer efficient protection against B. "
03/01/1989 - "pertussis was dependent on the dose of rat testicular homogenate in the inoculum and found to be effective only at lower doses of antigen (10 mg/rat). "
12/01/1975 - "A greater epidemiological efficacy of pertussis antigen was revealed by prolonged observation in immunization by the AKdeltaC-AKdeltaC-KB sheme in comparison with immunization by the official scheme (pertussis incidence per 100 thousand children proved to be 12.7 and 71.2, respectively)."

02/17/2016 - "It may be important to determine the functionality of antibodies to evaluate potential interference of maternal and infant vaccination in protection against pertussis."
07/01/2014 - "In addition to antibodies, Th1-type T cell responses are also important for long-lasting protection against pertussis. "
04/01/1999 - "These preliminary data suggest that CMI may have an important role in protection against clinical pertussis but do not exclude a role for antibodies. "
01/01/2022 - "Infants of immunized women have significantly higher transplacental antibodies for protection against pertussis disease during the first 2 months of life."
12/01/2005 - "pertussis induced rapid neutrophil recruitment and was rapidly cleared from the lungs by adoptively transferred antibodies. "

01/01/1999 - "Pertussis immunization coverage has improved dramatically since the introduction of acellular vaccines. "
05/16/2003 - "All tested whole-cell and acellular vaccines were significantly more effective than placebo against pertussis. "
01/01/2016 - "Furthermore, evidence from a recent non-human primate model suggests that acellular vaccines, although protective against pertussis disease, do not protect against B. "
11/01/2020 - "We found modest protection against PCR-confirmed pertussis among older adults (mean age, 61 years; range, 46-81 years) within 5 years after acellular vaccine. "
02/01/2012 - "National pertussis surveillance and vaccination coverage data, official pertussis vaccination recommendations, and medical and epidemiological sources related to the use, safety and efficacy of whole-cell and acellular vaccines were analysed. "

01/01/2009 - "A Japanese DPT vaccine dose of 0.2 mL thus proved effective against pertussis in adults."
05/01/1990 - "The point estimate of protective efficacy of the acellular DTP vaccine against typical pertussis was (6/10 - 1/9)/(6/10) x 100 = 81%. "
01/01/2023 - "We provide robust evidence that improved DTP vaccine timeliness, especially for the first dose, substantially reduces the burden of infant pertussis. "
01/01/1992 - "[Improvement in the laboratory methods of assessing the safety of the of the pertussis component of DPT vaccine adsorbed]."
09/01/2004 - "This study aims to evaluate the level of potency fluctuations of the pertussis component of Polish-produced DTP vaccine due to the changes having occurred in production and potency testing procedures. "

08/01/2004 - "pertussis was based on the amplification of a section of the IS481 insertion sequence and confirmation of positive results was based on a sequence of the pertussis toxin promoter region. "
11/01/2017 - "In this study, a neonatal mouse model of critical pertussis is characterized, and a central role for pertussis toxin (PT) is described. "
10/01/1987 - "pertussis strains were utilized to study the biogenesis of pertussis toxin. "
06/01/2023 - "pertussis, virulence-associated gene 8 (Vag8), causes coughing in combination with pertussis toxin and lipooligosaccharide. "
01/01/2023 - "Bordetella pertussis (Bp), the causative agent of "whooping cough", causes more serious disease in infants attributed to its production of pertussis toxin (PTx), although the neonate-specific immune functions it targets remain unknown. "

10/06/2023 - "However, hexavalent vaccines containing acellular pertussis antigens (DTaP-Hib-HB-IPV) and providing protection against the same diseases are also licensed, but are only available with a private prescription or for high-risk pre-term infants in the public health program. "
12/30/2021 - "Immunogenicity of a Candidate DTacP-sIPV Combined Vaccine and Its Protection Efficacy against Pertussis in a Rhesus Macaque Model."
10/25/2013 - "Experience with monocomponent acellular pertussis combination vaccines for infants, children, adolescents and adults--a review of safety, immunogenicity, efficacy and effectiveness studies and 15 years of field experience."
07/01/2020 - "Here, we give recommendations for the primary vaccination of infants in those countries where whole-cell pertussis (wP)- and acellular pertussis (aP)-containing combination vaccines are used in parallel. "
11/19/2019 - "HBV, Hib, poliovirus serotype 1, and pertussis), regardless of the type of hexavalent vaccine used. "

08/01/2005 - "Any combination of > or =3 DTP/DTaP vaccine doses for children 6 to 59 months of age was highly protective against pertussis. "
03/01/2016 - "Among adolescents who have only received DTaP vaccines in childhood, Tdap provided moderate protection against pertussis during the first year and then waned rapidly so that litle protection remained 2-3 years after vaccination.."
01/01/2018 - "The following study is an attempt to answer the question whether pertussis occurs more common in people vaccinated against pertussis with the DTwP or DTaP vaccine?"
07/17/2015 - "Sweden introduced DTaP vaccines in 1996 after a 17-year hiatus with no general pertussis vaccination and pertussis was still endemic at the time of the studies. "
01/01/2021 - "Association of Diphtheria-Tetanus-Acellular Pertussis Vaccine Timeliness and Number of Doses With Age-Specific Pertussis Risk in Infants and Young Children."

06/01/1999 - "The toxoid of PT should be sufficient for protection against pertussis."
04/19/2016 - "In summary, we showed for the first time that by measuring the activities of the two functional domains of PTx, we could characterise pertussis toxoids prepared from different chemical detoxification methods and this study also highlights the potential use of this in vitro biochemical assay system for in-process control. "
08/23/2021 - "pertussis mutant strain secreting only active PT and producing the enzymatically inactive CyaA-AC- toxoid failed to trigger any important mucus production in infected epithelial cell layers in vitro or in vivo in the tracheal epithelia of intranasally infected mice. "
02/01/2013 - "Chemically detoxified pertussis toxoids were able to translocate/internalize into cells at the concentration about 1,000 times higher than the native toxin. "
01/01/2010 - "Mass spectrometric analysis of multiple pertussis toxins and toxoids."

10/01/2023 - "This study assessed the medical records of 12 patients with severe pertussis requiring ET therapy who were admitted to our medical center. "
01/01/1947 - "Studies on redox therapy for pertussis."
10/01/2023 - "When the severe pertussis patients with T ≥ 38.5°C, CRP >30 mg/L, and WBC > 40.0 × 109/L, ET therapy might be taken into consideration."
10/01/2023 - "ET therapy worked effectively for our severe pertussis cases. "
01/01/2023 - "It also provides valuable information for an early clinical diagnosis and optimal choice of therapy for children with clinically suspected pertussis."

05/01/1998 - "pertussis strains are promising vectors for the simultaneous protection against pertussis and heterologous diseases by a single intranasal administration."
12/01/2019 - "Results from this study suggest that nasal administration of the PTd + FHA-loaded TMC NPs induced not only a systemic immune response but also a local mucosal response, which may improve the efficacy of pertussis prevention through respiratory tract transmission."
09/13/2020 - "pertussis colonization after a single nasal administration. "
10/08/2010 - "Long-term immunity against pertussis induced by a single nasal administration of live attenuated B. "
07/01/2005 - "Bordetella pertussis, the etiologic agent of whooping cough, is a highly infectious human pathogen capable of inducing mucosal and systemic immune responses upon a single intranasal administration. "

09/01/2008 - "Most infants (73%) were not vaccinated against pertussis, and the other children had received one or two injections. "
12/11/1999 - "However, when such combinations contain an acellular pertussis component (Pa), the antibody response to Hib is lower than that with separate injections and doubts have been raised about their efficacy. "
12/01/1994 - "Compared with other countries using four injections, incidence rates in Denmark are high, especially in pre-school years, leaving infants at a relatively high risk for contracting pertussis from siblings. "
04/01/1990 - "Serum antibody levels elicited by two injections of 50 micrograms were similar to those in patients convalescing from pertussis. "
01/01/1988 - "Pertussis immunization is only effective after 3 injections. "

09/09/2023 - "The purpose of this study was to measure the proportion of non-vaccination for pertussis in mothers in Canada who had been advised by their prenatal care provider to get vaccinated, and to identify sociodemographic factors and beliefs associated with non-vaccination. "
07/01/2018 - "This study aimed to describe the existing model of prenatal care in Quebec and determine to what extent maternal vaccination against pertussis could be integrated into this model. "
08/01/2015 - "The incidence of pertussis among neonates born to mothers who received prenatal care at Parkland Hospital showed a nonsignificant decline from 13 cases per 10,000 deliveries (19 of 14,834, 95% confidence interval [CI] 7-19) between January 2012 and May 2013 to seven per 10,000 deliveries during the study period (eight of 11,788, 95% CI 2-11, P=.174). "
11/03/2023 - "We developed a group-antenatal care (CP; Centering Pregnancy) intervention, i.e., a session about MPV within existing group-care settings, to promote informed decision making about Maternal Pertussis Vaccination in the Netherlands. "
11/03/2023 - "Promoting informed decision-making about maternal pertussis vaccination in Centering Pregnancy group-antenatal care: A feasibility study."

06/14/2014 - "The purpose of the present study was to verify the data availability, and consistency of six key maternal and child health indicators (first antenatal care, fourth antenatal care, skilled birth attendants, postnatal care, 'Bacillus Calmette Guerin and diphtheria-pertussis-tetanus third dose). "
01/01/2020 - "Using monthly data from the national Health Management Information System from January 2017 to January 2019, we examined rates of the use of nine health services at primary health facilities: total visits; first and fourth antenatal care visits; institutional deliveries; postnatal care visits; diphtheria, pertussis and tetanus (DTP) vaccinations and visits for uncomplicated malaria, pneumonia and diarrhoea. "
01/01/2020 - "Outcomes include annual maternal and child mortality rates and coverage (%) of family planning services, 1+antenatal care visit, skilled attendant at birth (SBA), exclusive breast feeding (0-5 months), early initiation of breast feeding (within 1 hour), neonatal protection against tetanus, newborn postnatal care within 2 days, 3 doses of diphtheria, pertussis and tetanus vaccine, measles vaccination, and careseeking for pneumonia and diarrhoea. "
10/09/2020 - "Data from three sources (Ugandan Demographic and Health (UDHS) survey, electronic RHIS, and census) were used to provide estimates of essential maternal (> 4 antenatal care visits (ANC), skilled delivery, and postnatal care visit (PNC)) and child health interventions (diphtheria, pertussis, tetanus, and hepatitis B and Haemophilus influenzae type b and polio vaccination series, measles vaccination, and vitamin A). "