White Muscle Disease

A myodegeneration most frequent in calves and lambs whose dams have been fed during gestation or longer on feeds, especially legumes (FABACEAE), grown in certain areas where selenium is either deficient or unavailable in the soil. It has been recorded in many countries. It has been produced experimentally in several species of animals on low-selenium intake. A similar myopathy occurs naturally in goats, deer, foals, and dogs but proof of the etiology is lacking. (Merck Veterinary Manual, 5th ed)

Also Known As:

Networked: 71 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Muscular Diseases (Myopathy)
2.	Necrosis
3.	Stomach Ulcer (Gastric Ulcer)
4.	Muscular Dystrophies (Muscular Dystrophy)
5.	Vitamin E Deficiency

Experts

1.	Arshad, Muhammad Adeel: 1 article (09/2021)
2.	Ebeid, Hossam Mahrous: 1 article (09/2021)
3.	Hassan, Faiz-Ul: 1 article (09/2021)
4.	Huyut, Zubeyir: 1 article (04/2019)
5.	Ozkan, Cumali: 1 article (04/2019)
6.	Yildirim, Serkan: 1 article (04/2019)
7.	Çınar, Ali: 1 article (04/2019)
8.	Bos, Jan H: 1 article (12/2017)
9.	Kik, Marja J L: 1 article (12/2017)
10.	Klip, Fokko C: 1 article (12/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to White Muscle Disease:

1.	SeleniumIBA 05/03/2017 - "White muscle disease in foals: focus on selenium soil content. " 06/01/2009 - "with the discovery of selenium deficiency causing "white muscle disease" in feedstock in the 1950s. " 03/01/2002 - "Lambs with white muscle disease and selenium content of soil and meadow hay in the region of Kars, Turkey." 08/01/2001 - "White muscle disease has been reported in young deer with blood and liver selenium concentrations of 84-140 nmol/l and 240-500 nmol/kg fresh tissue, respectively. " 04/01/1997 - "White muscle disease has been observed in foals from birth to 1 year of age, particularly those foals born to dams fed selenium-deficient diets, during gestation. "
2.	Vitamin EFDA LinkGeneric 12/01/2017 - "This case of neonatal white muscle disease is particularly remarkable given that the diet of the dam contained more than the recommended amount of vitamin E." 09/01/1978 - "[Vitamin E prophylaxis of white muscle disease]." 12/01/2017 - "It is well known that vitamin E and selenium deficiencies in domestic ruminants can lead to white muscle disease. " 10/21/2017 - "In calves, lambs and kids, the selenium deficiency demonstrates by WMD (white muscle disease), in foals and donkey foals, it is associated with incidence of WMD and yellow fat disease, and in pigs it causes VESD (vitamin E/selenium deficiency) syndrome. " 09/01/1980 - "The effects of dietary selenium and vitamin E on avian white muscle disease as measured by both chemical and physical parameters."
3.	Tocopherols (Tocopherol)IBA 08/01/1970 - "Tocopherol concentrations in the serum and liver of lambs with white muscle disease." 02/01/1989 - "Studies on serum selenium and tocopherol in white muscle disease of foal." 08/01/1990 - "Studies on serum tocopherol and selenium levels and blood glutathione peroxidase activities in lambs with white muscle disease." 08/01/1989 - "Studies on serum tocopherol, selenium levels and blood glutathione peroxidase activities in calves with white muscle disease." 08/01/1990 - "For the investigation of the cause of white muscle disease (WMD), tocopherol (Toc) and selenium (Se) levels and blood glutathione peroxidase (GSH-Px) activities were examined using lambs with WMD and their ewes. "
4.	Glutathione PeroxidaseIBA 11/01/1989 - "At this time, mean red cell glutathione peroxidase activities in the supplemented and unsupplemented groups were 430 and 11 U g-1 haemoglobin, respectively, and clinical white muscle disease had been observed in the latter group. " 09/01/1989 - "A survey of erythrocyte glutathione peroxidase (GPx) activity was undertaken in a herd of crossbred cattle after 3 cases of white muscle disease had been diagnosed. " 07/01/1977 - "With hydrogen peroxide as the substrate, tissue glutathione peroxidase activity was not correlated with the incidence of white muscle disease. " 08/01/1990 - "Studies on serum tocopherol and selenium levels and blood glutathione peroxidase activities in lambs with white muscle disease." 08/01/1989 - "Studies on serum tocopherol, selenium levels and blood glutathione peroxidase activities in calves with white muscle disease."
5.	EnzymesIBA 08/01/1975 - "It follows from the study that the examination of serum enzymes provides a method to demonstrate the clinical and pre-clinical forms of white-muscle disease and that it can be included in the set of tests for the diagnosis of diseases in calves. " 08/01/1975 - "It follows from the study that the examination of serum enzymes provides a method to demonstrate the clinical and pre-clinical forms of white-muscle disease and that it can be included in the set of tests for the diagnosis of diseases in calves. " 08/01/1975 - "[Activity of some serum enzymes in calves suffering from white muscle disease]." 03/26/1966 - "Activity of lysosomal enzymes in white muscle disease." 11/01/1978 - "Effects of various methods of selenium administration on white muscle disease, glutathione peroxidase and plasma enzyme activities in sheep."
6.	Troponin IIBA 01/01/2013 - "Evaluation of copper concentration in subclinical cases of white muscle disease and its relationship with cardiac troponin I." 06/01/2010 - "The aim of this study was to evaluate the use of human cardiac troponin-I (cTn-I) and cardiac troponin-T (cTn-T) kits for the determination of myocardial degeneration in lambs suffering from white muscle disease (WMD). " 01/01/2013 - "The present study aims to evaluate the serum level of copper (Cu) in lambs suffering from subclinical forms of white muscle disease (WMD) and its relationship with cardiac troponin I (cTn-I) as a novel biomarker of cardiovascular disorders. "
7.	trans-crotonin (CTN)IBA 06/01/2010 - "The aim of this study was to evaluate the use of human cardiac troponin-I (cTn-I) and cardiac troponin-T (cTn-T) kits for the determination of myocardial degeneration in lambs suffering from white muscle disease (WMD). " 01/01/2013 - "The present study aims to evaluate the serum level of copper (Cu) in lambs suffering from subclinical forms of white muscle disease (WMD) and its relationship with cardiac troponin I (cTn-I) as a novel biomarker of cardiovascular disorders. "
8.	Selenious Acid (Selenite)IBA 01/01/2008 - "The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. "
9.	Troponin T (Troponin T1)IBA 06/01/2010 - "The aim of this study was to evaluate the use of human cardiac troponin-I (cTn-I) and cardiac troponin-T (cTn-T) kits for the determination of myocardial degeneration in lambs suffering from white muscle disease (WMD). "
10.	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/01/2008 - "The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. "

Therapies and Procedures

1.	Injections 06/01/1973 - "Efficacy of selenium and vitamin E injections in the prevention of white muscle disease in young swine."
2.	Therapeutics 06/01/1975 - " Included in the study were 3 lactating ewes with lambs at foot and 3 lambs which had been weaned on to fodder low in selenium and were recovering from white muscle disease with Se therapy. " 06/01/1975 - "The ewes chosen were lactating ewes with lambs at foot, and the lambs were animals which had been weaned on to fodder low in selenium and were recovering from white muscle disease with selenium therapy. "
3.	Aftercare (After-Treatment) 01/01/2008 - "The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. "
4.	Total Parenteral Nutrition 12/01/1999 - "White muscle disease in humans: myopathy caused by selenium deficiency in anorexia nervosa under long term total parenteral nutrition."
5.	Intramuscular Injections 07/01/2004 - "Comparative data on the influence of selenium and cobalt inorganic compounds and their chelate complexes with methionin along with intramuscular injection of the vitamin preparation "Ursovit" on metabolism and treatment of calves with the symptoms of white muscle diseases are given in the paper. "