Vitellogenins (Vitellogenin)

Phospholipoglycoproteins produced in the fat body of egg-laying animals such as non-mammalian VERTEBRATES; ARTHROPODS; and others. Vitellogenins are secreted into the HEMOLYMPH, and taken into the OOCYTES by receptor-mediated ENDOCYTOSIS to form the major yolk proteins, VITELLINS. Vitellogenin production is under the regulation of steroid hormones, such as ESTRADIOL and JUVENILE HORMONES in insects.

Also Known As:

Networked: 235 relevant articles (2 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Arukwe, Augustine: 13 articles (12/2016 - 03/2003)
2.	Craft, John A: 7 articles (03/2013 - 01/2003)
3.	Casini, S: 5 articles (05/2007 - 12/2001)
4.	Fossi, M C: 5 articles (05/2007 - 12/2001)
5.	Denslow, Nancy D: 4 articles (01/2018 - 10/2002)
6.	Lehtonen, Kari K: 4 articles (03/2013 - 04/2009)
7.	Lindström, Kai: 4 articles (03/2013 - 04/2009)
8.	Saaristo, Minna: 4 articles (03/2013 - 04/2009)
9.	Marsili, L: 4 articles (05/2007 - 12/2001)
10.	Arukwe, A: 4 articles (09/2002 - 05/2001)

Related Diseases

1.	Body Weight (Weight, Body) 03/01/2015 - "Results from in vivo experiments revealed that 20E at 0.2 μg/g body weight significantly stimulated the expression of SpEcR and vitellogenin (SpVg) in female crabs during the early vitellogenic stage but not during the previtellogenic stage. " 12/01/2013 - "Exposure to 5.1, 8.1 and 16.8 ng EE2 L(-)(1) in water and 500 and 5000 ng EE2 kg(-)(1) body weight (bw) every second day in the food increased the plasma vitellogenin concentration in a concentration and time dependent manner, whereas exposure to 2.7 ng EE2 L(-)(1) in water for 21 d and 5 and 50 ng EE2 kg(-)(1) bw for 12 days in the food did not. " 09/01/2011 - "At doses of 0.01, 0.1, 1, 10 and 100 ng/g body weight, induction levels of circulating vitellogenin in Newark Bay females were inhibited by 89, 79, 61, 40 and 30%, respectively, compared to Tuckerton females. " 09/01/2011 - "At doses of 0.01, 0.1, 1 and 10 ng/g body weight, induction levels of circulating vitellogenin in Newark Bay males were significantly inhibited by 97, 99, 98 and 44%, respectively, compared to Tuckerton males. " 11/01/2005 - "Parasitic infestation was compared with body length, body weight, gonadal weight, gonadosomatic index and plasma vitellogenin levels, and revealed no statistically significant differences between non-parasitized and parasitized females. "
2.	Herpes Zoster 09/01/2006 - "In this study, we expanded an existing gene array for sheepshead minnows (Cyprinodon variegatus) (SHM) and used it to examine temporal changes in gene expression for male SHM exposed to 100 ng 17beta-estradiol (E(2))/L for five time points between 0 and 48 hr. We found that in addition to the induction of genes involved in oocyte development (vitellogenin [VTG], zona radiata [ZRP]), other genes involved in metabolism and the inflammatory response are also affected. " 12/01/2022 - "PCNA immunoreactivity was more intense in type I and II oocytes, while vitellogenin immunoreactivity occurred in the cytoplasm and follicular cells of oocytes III and IV. These data suggest that because of changes in the level/flow of the river, the gonads of these two species adjust to the new environment, with a decrease in mean diameter and zona radiata thickness of the oocytes, which can interfere with the reproduction of the animals." 12/01/2022 - "In S4, females had higher hepatic levels of vitellogenin and lower levels of zona radiata proteins. " 01/01/2018 - "It is known to regulate important proteins such as vitellogenin, the egg yolk precursor protein, and zona radiata proteins that form the eggshell for fish eggs. " 08/15/2017 - "In S2 and S3, there was an increase in the proportion of females, higher ELISA levels of vitellogenin (Vtg) and proteins of the zona radiata (Zrp) in liver males. "
3.	Breast Neoplasms (Breast Cancer) 07/01/2005 - "In this study, the (anti)estrogenic potential of several environmental chemicals were compared in an array of in vitro test systems comprising: (i) competitive binding to estrogen receptors derived from the human breast cancer cell line MCF-7 (hER) and rainbow trout (Oncorhynchus mykiss) (rtER), (ii) a proliferation assay with MCF-7 cells (E-SCREEN), and iii) induction of vitellogenin (rtVtg) in isolated rainbow trout hepatocytes. " 04/01/1993 - "To define a possible regulatory role of RXR beta regarding estrogen-responsive transcription in breast cancer cells, RXR beta and a reporter gene driven by the vitellogenin A2 ERE were transfected into estrogen-treated MCF-7 cells. " 09/26/1986 - "In the human breast cancer cell line MCF-7, we observe estrogen induction of the stable transfected Xenopus vitellogenin A2 gene. " 09/01/2007 - "Significant differences in estrogenic potential were observed between the two enantiomers in the in vitro human breast carcinoma MCF-7 cell proliferation assay (i.e., the E-SCREEN assay) and the in vivo aquatic vertebrate vitellogenin enzyme-linked immunosorbent assay (ELISA). " 12/01/2006 - "Accordingly, this article further examined the effects of the endogenous vitellogenin B1 estrogen responsive promotor on the SXR- and PPAR-gamma-modulated ER transactivation in Hep G2, and either dose-dependent or single dose effects of SXR, PPAR-gamma, and CAR in two different breast cancer cell lines and the ovarian-derived cell line respectively, on the ER-mediated transactivation of the synthetic (4ERE)-tk-luciferase reporter. "
4.	Infections 01/01/2019 - "This study examined the expression and role of vitellogenin (Vg) in the body of the firebug Pyrrhocoris apterus (Heteroptera, Insecta) during infection elicited by two entomopathogenic organisms, the nematode Steinernema carpocapsae and the fungus Isaria fumosorosea Infection by S. " 01/25/2021 - "Tomato Chlorosis Virus Infection Facilitates Bemisia tabaci MED Reproduction by Elevating Vitellogenin Expression." 11/01/2016 - "Vitellogenin gene expression was induced upon parasite exposure in all food treatments, suggesting infection-related interference with the host's reproductive system. " 12/01/2014 - "Nosema infections decrease honey bee longevity and transcription of vitellogenin, either with or without pollen feeding. " 10/01/2012 - "A total of 247 contigs showed differential expression in response to CLs infection including immune and stress-related genes and vitellogenins. "
5.	Triploidy 03/01/2016 - "Decreased abundance of vitellogenin in heat-shock treated eggs in our study may either be explained by (i) higher utilization of vtg as an effect of increased cell size in triploids or (ii) changed metabolism in response to heat-shock stress and (iii) diffusion of vtg through chorion due to incidence of egg shell damage. " 12/20/2022 - "Our results indicate that 17α-ethinylestradiol consumption does induce vitellogenin production in triploid zebrafish. " 12/20/2022 - "We aimed to determine whether ethinylestradiol peroral administration resulted in vitellogenin production and whether all-male triploid zebrafish could serve as a model species for xenoestrogen testing. " 03/01/2016 - "Decreased abundance of vitellogenin in heat-shock treated eggs was associated with reduced early survival rates and lowered growth performance of triploid fish." 03/01/2003 - "Plasma vitellogenin was significantly higher in E(2)-treated-triploids than in control-triploids and diploids at every month except October 1999. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Solvents
3.	Arginine (L-Arginine)
4.	Estrogen Receptors
5.	Estrogens (Estrogen)
6.	Biomarkers (Surrogate Marker)
7.	Messenger RNA (mRNA)
8.	Estradiol (Delestrogen)
9.	Protein Isoforms (Isoforms)
10.	Aromatase (CYP19)

Related Therapies and Procedures

1.	Contraception (Birth Control)
2.	Aftercare (After-Treatment)