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Vitamin D-Binding Protein

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An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.

Also Known As:

25-HCC-Binding Protein; 25-Hydroxycholecalciferol-Binding Protein; 25-Hydroxyvitamin D-Binding Protein; Calciferol-Binding Protein; Gc Globulin; Transcalciferin; 25 HCC Binding Protein; 25 Hydroxycholecalciferol Binding Protein; 25 Hydroxyvitamin D Binding Protein; Calciferol Binding Protein; Component Globulin, Group-Specific; Globulin, Gc; Globulin, Group-Specific Component; Globulin, Vitamin D-Binding; Group Specific Component Globulin; Vitamin D Binding Globulin; Vitamin D Binding Protein; Group-Specific Component Globulin; Vitamin D-Binding Globulin

Networked: 159 relevant articles (2 outcomes, 29 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 58309
  - Carrier Proteins: 7706
    - Vitamin D-Binding Protein: 159
      - vitamin D-binding protein-macrophage activating factor: 24

Experts

1.	Schiødt, F V: 5 articles (01/2007 - 01/2001)
2.	Dahl, B: 4 articles (01/2007 - 01/2001)
3.	Gressner, Axel M: 3 articles (09/2009 - 07/2006)
4.	Schiødt, Frank V: 3 articles (09/2007 - 01/2003)
5.	Lee, William M: 3 articles (09/2007 - 01/2003)
6.	Ott, P: 3 articles (09/2001 - 01/2001)
7.	Kim, Philipp: 2 articles (09/2009 - 02/2009)
8.	Gressner, Olav A: 2 articles (02/2009 - 08/2008)
9.	Yamamoto, Nobuyuki: 2 articles (07/2008 - 01/2008)
10.	Yamamoto, Nobuto: 2 articles (07/2008 - 01/2008)

Related Diseases

1.	Necrosis 07/01/2006 - "Clinical studies and animal models have shown that Gc-globulin has an important role in the clearance of procoagulant actin from the circulation after its release during cell necrosis and tissue injury. " 08/01/2008 - "Despite this increase Gc-globulin levels were severely reduced and the reduction must therefore be due to a highly increased consumption of Gc-globulin - probably because of hepatocyte necrosis and removal from the circulation of Gc-globulin:actin complexes or because of its role in immune-related functions. " 08/01/2008 - "Actin is a major cellular protein released during cell necrosis that may cause fatal formation of actin-containing thrombi in the circulation if the actin scavenging capacity of Gc-globulin is exceeded. " 06/01/1988 - "Alterations in circulating levels of vitamin D-binding protein (Gc) and the percentage of Gc in complexed form were further studied in normal subjects and in patients with fulminant hepatic necrosis in relation to clinical outcome. " 06/01/1988 - "Proportion of circulating Gc (vitamin D-binding protein) in complexed form: relation to clinical outcome in fulminant hepatic necrosis." Order ALL the reference details at left...
2.	Hyperparathyroidism 06/01/2000 - "Ovx-induced exacerbation of hyperparathyroidism was confirmed by significantly greater conversion of 25-hydroxyvitamin D to 1, 25-dihydroxyvitamin D in ovx NA rats even after normalization to vitamin D-binding protein. " Order ALL the reference details at left...
3.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2004 - "BACKGROUND: Previous studies of vitamin D binding protein (VDBP, also known as group-specific component, Gc, encoded by the GC gene) have implicated two gene variants, GC2 and GC1F, as possible contributors with chronic obstructive pulmonary disease (COPD) protection and susceptibility, respectively. " 01/01/2004 - "STUDY OBJECTIVE:s: To determine whether Gc-globulin gene polymorphism plays a role in the development of COPD in the Japanese population, and whether it is associated with the physiologic deterioration in COPD, and its radiologically detectable correlates. " 03/01/1998 - "There have been three previous studies in which associations between Gc-globulin phenotypes and COPD have been investigated. " 01/01/2007 - "SNPs nearby the SOD3 and vitamin D binding protein genes, candidate genes for COPD, exhibited association to percent predicted phenotypes. " 03/01/2006 - "The distribution of alleles and genotypes of vitamin D-binding protein (DBP) gene has been studied in patients with Chronic Obstructive Pulmonary Disease (COPD, n = 298) and healthy individuals (n = 237) from two ethnic groups (Tatars and Russians) living in Republic Bashkortostan. " Order ALL the reference details at left...
4.	Osteoporosis 07/01/2008 - "SUMMARY: Here we report the results of a vitamin D-binding protein gene microsatellite polymorphism study in 170 men, comprising healthy male subjects and men with osteoporosis-related symptomatic vertebral fractures. " 08/01/2009 - "Vitamin D binding protein genotype and osteoporosis." 10/01/1999 - "Vitamin D binding protein gene in male osteoporosis: association of plasma DBP and bone mineral density with (TAAA)(n)-Alu polymorphism in DBP." 11/01/1982 - "[Vitamin D-binding protein in senile osteoporosis]" 01/01/2004 - "AIM: To study polymorphism of genes involved in mechanisms regulating metabolism of bone tissue: alkaline (ALPL) and acid (ACP1) phosphatases, vitamin D-binding protein (GC); to ascertain associations of their genotypes and alleles with osteoporosis (OP) and mineral density of spinal and femoral bone tissue (BTMD). " Order ALL the reference details at left...
5.	Wounds and Injuries (Trauma) 02/01/2001 - "Recent studies have shown that the level of Gc-globulin is reduced shortly after trauma. " 02/01/2009 - "This presumption was supported by the fact that those conditions associated with a severe neuronal damage, in particular CNS trauma, and highest S100-B concentrations simultaneously displayed lowest actinfree Gc-Globulin levels, and thus residual actin binding capacity of Gc-Globulin. " 02/01/2001 - "Serial measurements of Gc-globulin after trauma could prove to be a method of early identification of patients with increased risk of mortality." 02/01/2001 - "Serial changes in Gc-globulin after severe injury have not been studied so far and could provide additional information about the role of Gc-globulin in the pathophysiological response to trauma. " 02/01/2001 - "Trauma stimulates the synthesis of Gc-globulin." Order ALL the reference details at left...

Related Drugs and Biologics

1.	25-hydroxyvitamin D
2.	Vitamin D
3.	hydroxide ion
4.	Proteins (Proteins, Gene)
5.	Glycoproteins (Glycoprotein)
6.	vitamin D-binding protein-macrophage activating factor
7.	Calcitriol Receptors (Calcitriol Receptor)
8.	Transferrin (beta 2 Transferrin)
9.	Actins (F Actin)
10.	alpha-Macroglobulins (alpha 2 Macroglobulin)

Related Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
2.	Immunotherapy
3.	Liver Transplantation
4.	Transplantation (Transplant Recipients)
5.	Peritoneal Dialysis

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