Vinyl Chloride (Chloroethylene)

A gas that has been used as an aerosol propellant and is the starting material for polyvinyl resins. Toxicity studies have shown various adverse effects, particularly the occurrence of liver neoplasms.

Also Known As:

Networked: 554 relevant articles (3 outcomes, 55 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Beier, Juliane I: 10 articles (05/2021 - 02/2013)
2.	Fedeli, Ugo: 7 articles (01/2022 - 08/2004)
3.	Mastrangelo, Giuseppe: 7 articles (01/2022 - 08/2004)
4.	Lang, Anna L: 6 articles (12/2020 - 11/2016)
5.	Wang, Jung-Der: 6 articles (02/2011 - 02/2002)
6.	Boffetta, Paolo: 5 articles (08/2013 - 06/2003)
7.	Cheng, Tsun-Jen: 5 articles (02/2011 - 05/2002)
8.	McClain, Craig J: 4 articles (05/2021 - 02/2010)
9.	Marsh, Gary M: 4 articles (02/2021 - 03/2007)
10.	Chan, Chang-Chuan: 4 articles (10/2020 - 02/2002)

Related Diseases

1.	Occupational Diseases (Occupational Disease) 11/20/2022 - "Conclusion: To protect the health of workers and prevent occupational diseases, the management of vinyl chloride exposure on production process, especially in domestic enterprise, should be improved. " 12/01/2010 - "Hepatic angiosarcoma caused by vinyl chloride monomer (VCM) exposure is a very well known occupational disease and it has not been officially reported in Korea yet. " 01/01/1985 - "Occupational diseases resulting from exposure to vinyl chloride (VC) include angiosarcoma of the liver and other neoplasms. " 03/01/2010 - "In our view acroosteolysis of manual tank cleaners in PVC production is an occupational disease which is distinct from "vinyl chloride disease" as identified by Viola (1974)." 05/01/1993 - "Hand-arm vibration disease, hypothenar hammer syndrome, exposure to silica even without silicosis and vinyl chloride intoxication are the principal causes of occupational diseases acknowledged as such by the laws. "
2.	Acquired Immunodeficiency Syndrome (AIDS) 01/01/1980 - "The contamination of dietary fats and oils can have various origins: contamination of the raw materials that could not be eliminated by the industrial process; refining completely eliminates this type of contamination; contamination with one of the processing aids can occur if the process is not properly conducted; contamination with packaging materials will increase with the storage duration of the finished product (in the case of vinyl chloride monomer and styrene contamination); only the strict control and adequate choice of the materials and packaging conditions will allow complete elimination of this contamination type. " 10/01/2019 - "This scientific opinion of the EFSA Panel on Food Contact Materials, Enzymes and Processing aids (CEP Panel) is on the safety assessment of trimellitic acid, tris(2-ethylhexyl) ester, intended to be used as a plasticiser in the manufacture of soft poly(vinyl chloride) (PVC) materials and articles, such as wrap films (single uses) and tubing (repeated uses) at up to approximately 10% and 40%, respectively. " 04/01/2001 - "Beside the well investigated role of the human immunodeficiency virus 1 (HIV-1) and the human herpesvirus 8 (HHV-8) in the tumorigenesis of AIDS-related Kaposi's sarcoma and several inherited disorders, considerable evidence support a relationship between occupational chemicals as vinyl chloride, phenoxyacetic acid herbicides, chlorphenols, dioxin, medicinal measures as Thorotrast exposure and therapeutic irradiation, and the development of soft tissue sarcoma. " 05/01/2020 - "The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the substance (triethanolamine-perchlorate, sodium salt) dimer, FCM substance No 1080, intended to be used as a thermal stabiliser at up to 0.15% w/w in rigid poly(vinyl chloride) (PVC) for repeated use bottles in contact with water. "
3.	Larva Migrans (Cutaneous Larva Migrans) 05/01/1951 - "[Case of larva migrans rapidly cured with chloroethylene]."
4.	Hemangiosarcoma (Angiosarcoma) 07/01/1998 - "This study offers new evidence of the occurrence of vinyl-chloride-induced angiosarcomas outside the liver and confirms observations that have previously been published in case reports. " 05/01/1997 - "Vinyl chloride causes angiosarcoma of the liver, but a large, multi-country study provided no clear evidence that other sites are affected." 01/01/1997 - "In the period of study, there were no confirmed non-occupationally exposed cases of angiosarcoma among residents living near a vinyl chloride site in Great Britain." 10/01/1981 - "This study demonstrated that older adult animals and females are more susceptible to the angiosarcoma-inducing effects of vinyl chloride than young adult animals and males, respectively." 01/01/1981 - "This study suggests that there is no basic difference in ultrastructure between the vinyl chloride-induced hemangiosarcomas and hemangiosarcomas not related to this chemical exposure."
5.	Neoplasms (Cancer) 06/01/2003 - "A meta-analysis was made of studies addressing occupational exposure to vinyl chloride in relation to cancer mortality. " 06/01/2003 - "Meta-analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality." 06/01/1991 - "A collaborative study of cancer incidence and mortality among vinyl chloride workers." 04/05/2020 - "Vinyl chloride monomer (VCM) is classified as group 1 carcinogenic to humans by the International Agency for Research for Cancer (IARC). " 04/01/2014 - "Hepatobiliary cancer mortality was elevated among workers ever exposed to vinyl chloride (SMR = 3.80, 95% confidence interval 1.89-6.80); directly standardized rates increased with increasing vinyl chloride exposure duration. "

Related Drugs and Biologics

1.	Styrene (Styrol)
2.	Oils
3.	Dietary Fats (Dietary Fat)
4.	Carcinogens
5.	Arsenic
6.	Chloroprene
7.	Polyvinyl Chloride (PVC)
8.	Thorium Dioxide (Thorotrast)
9.	DNA (Deoxyribonucleic Acid)
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Radiotherapy
2.	Therapeutics
3.	Critical Care (Surgical Intensive Care)
4.	Breast Implants (Breast Implant)
5.	Transplantation