Veterinary Venereal Tumors (Transmissible Venereal Tumor)

Tumors most commonly seen on or near the genitalia. They are venereal, most likely transmitted through transplantation of cells by contact. Metastases have been reported. Spontaneous regression may occur.

Also Known As:

Transmissible Venereal Tumor; Venereal Tumors, Veterinary; Transmissible Venereal Tumors; Tumors, Transmissible Venereal; Tumors, Veterinary Venereal; Tumor, Transmissible Venereal; Tumor, Veterinary Venereal; Venereal Tumor, Transmissible; Venereal Tumor, Veterinary; Veterinary Venereal Tumor; Venereal Tumors, Transmissible

Networked: 67 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Seminoma
3.	Necrosis
4.	Leukemia
5.	Hematologic Neoplasms (Hematological Malignancy)

Experts

1.	Chu, Rea-Min: 9 articles (11/2012 - 09/2003)
2.	Chuang, Tien-Fu: 5 articles (04/2011 - 12/2008)
3.	Liao, Kuang-Wen: 5 articles (08/2009 - 09/2003)
4.	Coronado-Cerda, Erika Evangelina: 3 articles (02/2019 - 10/2018)
5.	Franco-Molina, Moisés Armides: 3 articles (02/2019 - 10/2018)
6.	Ramos-Zayas, Yareellys: 3 articles (02/2019 - 10/2018)
7.	Rodríguez-Padilla, Cristina: 3 articles (02/2019 - 10/2018)
8.	Zapata-Benavides, Pablo: 3 articles (02/2019 - 10/2018)
9.	Hsiao, Ya-Wen: 3 articles (08/2009 - 02/2004)
10.	Mendoza-Gamboa, Edgar: 2 articles (02/2019 - 10/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Veterinary Venereal Tumors:

1.	Vincristine (Oncovin)FDA LinkGeneric 12/01/2014 - "This study was conducted to evaluate the pharmacokinetic characteristics of vincristine and their correlation with its clinical effects in dogs with transmissible venereal tumor (TVT). " 03/15/2000 - "The aim of this study was to evaluate the direct effects of vincristine on semen quality in dogs with transmissible venereal tumor (TVT). " 05/01/2019 - "Chemotherapeutic treatment for Canine transmissible venereal tumor (CTVT) commonly relies on vincristine administration. " 05/01/2019 - "Factor Analysis for Bicluster Acquisition (FABIA) revealed vincristine-sensitive transcript pattern of canine transmissible venereal tumors." 12/01/2014 - "Clinical pharmacokinetics and effects of vincristine sulfate in dogs with transmissible venereal tumor (TVT)."
2.	Interleukin-2 (IL2)IBA 02/01/2015 - "Treatment of transmissible venereal tumors in dogs with intratumoral interleukin-2 (IL-2). " 02/01/2015 - "To improve the treatment of transmissible venereal tumors (TVTs) in dogs with intratumoral injections of interleukin-2 (IL-2). " 06/01/2015 - "Effective Treatment of Transmissible Venereal Tumors in Dogs with Vincristine and IL2."
3.	Hypochlorous Acid (Hypochlorite)IBA 12/01/2018 - "We evaluated the in vitro efficacy of three different preparations of canine transmissible venereal tumor (TVT) cell lysates: hypochlorous acid-whole tumor cell lysates (HOCl-L), heat shock-whole tumor cell lysates (HS-L), and freeze-thaw cycles-whole tumor cell lysates (FT-L) for the maturation of canine-derived dendritic cells. "
4.	AntigensIBA 02/01/2019 - "The aim of this study was to demonstrate the use of exosomes derived from canine transmissible venereal tumor (CTVT) as an antigen to pulsed dendritic cells and its administration in dogs with CTVT as treatment against this disease. " 07/15/2009 - "Canine transmissible venereal tumor (CTVT) is a tumor with low MHC antigen expression and is an ideal tumor model for studying the interactions between host immunity and cancer cells. " 07/01/2008 - "Using an in vivo canine-transmissible venereal tumor (CTVT) tumor model, we presently assessed IL-6 and TGF-beta involvement associated with the MHC antigen expression that is commonly suppressed in cancers. "
5.	Proteins (Proteins, Gene)FDA Link 05/29/2023 - "This study proposed a framework to assess the effect of vincristine chemotherapy on intraocular pressure, tear protein, and oxidative stress in canines with transmissible venereal tumor (TVT). " 05/01/1996 - "The collective immunohistochemical expression of human lysozyme, human alpha-1-antitrypsin, human CD3 antigen, calf vimentin, human keratins, human lambda light chains,canine immunoglobulins IgG, IgM, and bovine protein S-100 has been analyzed on formalin-fixed, paraffin-embedded tissue sections of 25 spontaneous canine transmissible venereal tumors (CTVT) from both genital and extragenital locations using the avidin-biotin-peroxidase complex technique. "
6.	DNA VaccinesIBA 04/18/2011 - "This study tested a xenogeneic chicken HSP70 (chHSP70) DNA vaccine in an experimental canine transmissible venereal tumor (CTVT) model. "
7.	Oxidants (Oxidizing Agents)IBA 06/01/2023 - "Vincristine-associated total antioxidant and oxidant status of ovaries and in vitro nuclear oocyte maturation in dogs with canine transmissible venereal tumor." 06/01/2023 - "The aim of this study is to evaluate the effects of scheduled vincristine sulfate therapy on canine oocyte quality and nuclear oocyte maturation, associated with total antioxidant and oxidant status of ovaries and Anti-Müllerian Hormone (AMH) concentrations in dogs with Canine Transmissible Venereal Tumor (CTVT). "
8.	Hormones (Hormone)IBA 06/01/2023 - "The aim of this study is to evaluate the effects of scheduled vincristine sulfate therapy on canine oocyte quality and nuclear oocyte maturation, associated with total antioxidant and oxidant status of ovaries and Anti-Müllerian Hormone (AMH) concentrations in dogs with Canine Transmissible Venereal Tumor (CTVT). "
9.	AntioxidantsIBA 06/01/2023 - "Vincristine-associated total antioxidant and oxidant status of ovaries and in vitro nuclear oocyte maturation in dogs with canine transmissible venereal tumor." 06/01/2023 - "The aim of this study is to evaluate the effects of scheduled vincristine sulfate therapy on canine oocyte quality and nuclear oocyte maturation, associated with total antioxidant and oxidant status of ovaries and Anti-Müllerian Hormone (AMH) concentrations in dogs with Canine Transmissible Venereal Tumor (CTVT). "
10.	7- O- (2,6- dideoxy- 2- fluorotalopyranosyl)daunomycinoneIBA 01/01/2019 - "Known as devil facial tumor disease (DFTD) and canine transmissible venereal tumor (CTVT), transmissible cancer occurs in both Tasmanian devil and canine populations, respectively. " 01/01/2016 - "Canine transmissible venereal tumors (CTVT) are likely thousands of years old, and have successfully travelled from host to host around the world, while the Tasmanian devil facial tumor disease (DFTD) is much younger and geographically localized. " 12/01/2011 - "Tasmanian devil facial tumor disease (DFTD) and canine transmissible venereal tumor (CTVT) are highly unusual cancers capable of being transmitted between animals as an allograft. " 12/01/2008 - "Tasmanian devil facial tumor disease (DFTD) and canine transmissible venereal tumor (CTVT) are the only known naturally occurring clonally transmissible cancers. " 11/01/2015 - "So far, four types of transmissible tumors including canine transmissible venereal tumor (CTVT),Tasmanian devil facial tumor disease (DFTD), soft-shell clams leukemia (SSCL), and hamsters reticulum cell sarcoma (HRCS)have been discovered and identified. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 07/01/1980 - "Autologous bone marrow infusion following high dose chemotherapy of the canine transmissible venereal tumor (TVT)." 02/01/1977 - "Transmissible venereal tumor: surgery and chemotherapy. " 07/01/1980 - "It was concluded that: a) cryopreserved autologous bone marrow infusion was effective in protecting tumor bearing canines from otherwise lethal chemotherapy; b) the transmissible venereal tumor of canines responded to both high and low dose regimes; c) the rescue of dogs by stored autologous marrow did not offer additional benefits in tumor control over a standard regime; d) chemotherapy treated dogs resisted tumor rechallenge. " 11/05/2016 - "Retraction Note to: Canine transmissible venereal tumor and seminoma: a cytohistopathology and chemotherapy study of tumors in the growth phase and during regression after chemotherapy." 06/01/2014 - "Canine transmissible venereal tumor and seminoma: a cytohistopathology and chemotherapy study of tumors in the growth phase and during regression after chemotherapy."
2.	Therapeutics 11/01/1977 - "Canine transmissible venereal tumors were studied for response to intralesional Bacillus Calmette-Guérin (BCG) therapy. " 03/01/2010 - "Predictive factors for the regression of canine transmissible venereal tumor during vincristine therapy." 06/01/2023 - "The aim of this study is to evaluate the effects of scheduled vincristine sulfate therapy on canine oocyte quality and nuclear oocyte maturation, associated with total antioxidant and oxidant status of ovaries and Anti-Müllerian Hormone (AMH) concentrations in dogs with Canine Transmissible Venereal Tumor (CTVT). "
3.	Immunotherapy 02/01/2019 - "Immunotherapy for the treatment of canine transmissible venereal tumor based in dendritic cells pulsed with tumoral exosomes." 01/01/2019 - "Canine transmissible venereal tumor (CTVT) is used as an animal model for immunotherapy due to its specific growth phase. " 10/01/2018 - "Autologous canine immunotherapy: short-time generated dendritic cells loaded with canine transmissible venereal tumor-whole lysate." 12/01/2018 - "Immunogenic potential of three transmissible venereal tumor cell lysates to prime canine-dendritic cells for cancer immunotherapy." 02/15/2011 - "Immunopathogenic behaviors of canine transmissible venereal tumor in dogs following an immunotherapy using dendritic/tumor cell hybrid."
4.	Transplantation 12/01/1981 - "Histological and Ultrastructural findings of regressing canine transmissible venereal tumor after repeated transplantation." 03/01/2010 - "Canine transmissible venereal tumor (CTVT) is a neoplasm transmitted by transplantation. " 01/01/2009 - "Canine transmissible venereal tumor (CTVT) is an intriguing cancer that is transmitted naturally as an allograft by transplantation of viable tumor cells from affected to susceptible dogs. " 08/01/2005 - "In this report, we characterize the experimental transplantation of the canine transmissible venereal tumor in the brain, skin, muscle, prostate, lung, liver, and bone of dogs and provide X-ray computed tomographic and magnetic resonance imaging characteristics of the tumors in the brain, muscle, lung, and prostate."
5.	Intravenous Administration 01/01/1984 - "Treatment of canine transmissible venereal tumor by intravenous administration of protein A."