|1.||Wegener Granulomatosis (Wegener's Granulomatosis)
|5.||Systemic Lupus Erythematosus (Libman-Sacks Disease)
|1.||Guillevin, Loïc: 76 articles (12/2015 - 02/2002)|
|2.||Falk, Ronald J: 45 articles (04/2015 - 01/2002)|
|3.||Cacoub, Patrice: 43 articles (12/2015 - 01/2002)|
|4.||Pagnoux, Christian: 43 articles (11/2015 - 04/2003)|
|5.||Kallenberg, Cees G M: 42 articles (01/2016 - 01/2002)|
|6.||Jayne, David: 35 articles (10/2015 - 07/2003)|
|7.||Jennette, J Charles: 35 articles (06/2015 - 01/2002)|
|8.||Zhao, Ming-Hui: 34 articles (11/2015 - 05/2004)|
|9.||Chen, Min: 33 articles (11/2015 - 11/2005)|
|10.||Mouthon, Luc: 31 articles (12/2015 - 11/2003)|
|1.||Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
03/01/2013 - "3) The ANCA test is highly specific for these types of autoimmune vasculitides but renal biopsy still remains the gold standard for final diagnosis, prognostic evaluation and therapeutic intervention, although discrepancy between clinical and morphological features is frequently found. "
12/01/2007 - "Most patients with PTU-associated ANCA-positive vasculitis had good outcomes; however, severe cases existed. "
01/01/2004 - "Furthermore, the yield of antineutrophil cytoplasmic antibody testing can be improved by the use of a well-standardized test, adherence to published guidelines, and restricting the use of the tests to clinical situations with a rather high pretest probability for antineutrophil cytoplasmic antibody-associated vasculitides. "
07/01/2002 - "These results show that ANCA-positive vasculitis patients have high sFas levels and that the levels remain elevated even in clinical remission. "
05/01/2000 - "Despite the improved outcome of patients with ANCA vasculitis in the recent decade, their long-term prognosis continues to be primarily determined by a rapid diagnosis, and the prompt institution of therapy."
|2.||Cyclophosphamide (Cytoxan)FDA LinkGeneric
10/01/2010 - "Combination therapy of corticosteroid and cyclophosphamide resulted in marked improvement of clinical symptoms, amelioration of renal function and lack of subsequent relapse of vasculitis. "
01/01/1985 - "The combination of the priming doses of 6-MP and cyclophosphamide holds promise in the treatment of patients with associated SLE and grave renal involvement, marked immunologic disorders and generalized autoimmune vasculitis."
02/08/1980 - "From the NIH: Cyclophosphamide may be effective in severe vasculitis."
09/01/1992 - "Angiitis showed no improvement with corticosteroid alone, but improved markedly with corticosteroid plus cyclophosphamide. "
01/01/1993 - "The first controlled study of cyclophosphamide as therapy for necrotizing vasculitis confirms its early benefit but, interestingly, shows no difference in 10-year survival rates. "
|3.||glucuronyl glucosamine glycan sulfate (Vessel)IBA
05/01/2011 - "If one accepts the premise that there are few cures at present for idiopathic large- and small-vessel vasculitis, we will serve our patients well if we can determine the most effective initial therapy that leads to a maintenance strategy for remission with least risk. "
06/01/2005 - "[(18)F]FDG-PET is highly effective in assessing the activity and the extent of large-vessel vasculitis. "
04/01/2005 - "What is the best approach to diagnosing large-vessel vasculitis?"
07/01/2015 - "Here, we present a rare case of cerebral large vessel vasculitis treated successfully with a clear visual presentation. "
09/01/1999 - "Both GCA and small vessel primary vasculitis had a good outcome. "
|4.||rituximab (Mabthera)FDA Link
01/01/2012 - "Several studies have demonstrated that rituximab is highly effective when cryoglobulinaemic vasculitis is refractory to antiviral regimen, that association of rituximab with antiviral regimen may induce a better and faster clinical remission, and, recently, that rituximab is more efficient than traditional immunosuppressive treatments. "
03/01/2012 - "We conducted a single-center, open-label, randomized controlled trial of rituximab (375 mg/ m(2) /week for 4 weeks) compared to the best available therapy (maintenance or increase in immunosuppressive therapy) for HCV-associated cryoglobulinemic vasculitis in patients in whom antiviral therapy had failed to induce remission. "
03/01/2012 - "After 6 months of rituximab therapy, 12 patients (71%) achieved complete remission of their vasculitis, 4 had a partial response, and 1 died with uncontrolled vasculitis. "
10/01/2015 - "Rituximab at a low dosage of 250 mg/m(2) × 2 is as effective as at higher dosages for treating MC vasculitis. "
03/01/2012 - "Rituximab was a well-tolerated and effective treatment in patients with HCV-associated cryoglobulinemic vasculitis in whom antiviral therapy failed to induce remission."
|5.||Adrenal Cortex Hormones (Corticosteroids)IBA
03/01/2008 - "From the introduction of corticosteroids and immunosupressives, vasculitis were no more a mortal diseases, and it was possible to obtain high rates of remission. "
04/01/2004 - "After starting the treatment with gancyclovirus and corticosteroids, the considerable improvement of clinical signs of the frosted branch angiitis was noticed. "
08/01/1979 - "Corticosteroids have been effective in controlling the clinical symptoms as well as the vasculitis."
07/01/1993 - "Corticosteroids and other immunosuppressive drugs have been used to treat pulmonary vasculitis, but the efficacy of these agents has not yet been established. "
03/01/2001 - "Although cytomegalovirus antigenemia resolved, the angiitis only improved after subsequent treatment with systemic corticosteroids. "
|6.||Azathioprine (Imuran)FDA LinkGeneric
09/01/2001 - "Azathioprine may have induced the remission of vasculitis in one case."
01/01/2012 - "Maintenance therapy was continued with azathioprine and the patient currently remains without evidence of active vasculitis. "
07/01/1996 - "We review the literature concerning adverse reactions to azathioprine and the problems of making the diagnosis as well as highlighting azathioprine as a novel cause of leucocytoclastic vasculitis."
07/01/1996 - "He developed histologically proven cutaneous leucocytoclastic vasculitis following the re-introduction of azathioprine. "
12/01/1984 - "After immunosuppressive (azathioprine) therapy was discontinued, pulmonary, bowel, and cutaneous vasculitis promptly appeared and the diagnosis of WG was finally made. "
|7.||Antigen-Antibody Complex (Immune Complex)IBA
12/01/1999 - "The deposition of circulating HCV-containing immune complexes (CIC) in the skin could be the initial pathogenic event for cryoglobulinemic vasculitis; subsequently CIC could spread from the vascular bed to the perivascular tissue and then could be very rapidly eliminated. "
03/15/1992 - "In studies of immune complex (BSA-anti-BSA)-induced alveolitis and dermal vasculitis, anti-CD18 had protective effects at all doses of anti-BSA employed. "
12/01/2006 - "Biopsy is the gold standard for the diagnosis of cutaneous vasculitis and also necessary for the detection of cutaneous vascular immune complexes by direct immunofluorescence. "
08/01/1989 - "Even vasculitis may be a consequence of failure of clearance of immune complexes from the interstitium. "
05/01/2015 - "This study shows that MPO activity is critical in driving immune complex vasculitis and provides confidence in testing the hypothesis that MPO inhibition will provide benefit in treating human vasculitic diseases. "
|8.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/01/2008 - "While the inhibition of TNF-alpha has been shown to improve vasculitis in vitro and in animal models, the clinical evidence for the efficacy of TNF-alpha blockade in most forms of vasculitis is mainly based on case reports and case series. "
01/01/2006 - "In conclusion, these findings indicate that TNF-alpha plays an important role in the pathogenesis of experimental autoimmune vasculitis and suggest that blockade of this cytokine with an mAb is effective in treating established vasculitis. "
06/01/2002 - "Safety and efficacy of TNFalpha blockade in relapsing vasculitis."
12/01/2006 - "Vasculitides induced by TNFalpha antagonists: a study in 39 patients in France."
01/01/2016 - "Cutaneous Vasculitis Caused by Anti-Tumor Necrosis Factor Therapy: A Case Report."
|9.||Methotrexate (Mexate)FDA LinkGeneric
03/01/1993 - "With methotrexate, nodulosis and vasculitis were stable in 31 cases, improved in 3 and worsened in 10 (23%). "
07/01/2000 - "Methotrexate-induced exacerbation of urticarial vasculitis: an unusual adverse reaction."
01/01/1997 - "Methotrexate related cutaneous vasculitis."
11/20/1994 - "vasculitis, pulmonary or cardial manifestation--necessitate the discontinuation of methotrexate."
01/01/1994 - "Methotrexate for urticarial vasculitis."
08/15/2010 - "To the best of our knowledge, this is the first case of eosinophilic vasculitis of the spinal cord associated with CSS, and the patient responded well to steroids."
05/01/1998 - "Treatment of ocular symptoms of Behçet's disease with IFN alpha 2a alone or in combination with low dose steroids led to complete remission of ocular vasculitis in all patients treated in this open, uncontrolled trial. "
06/01/1998 - "After apparent complete KS remission, acute periorbital vasculitis developed in the left upper eyelid and orbit, requiring operative intervention for diagnosis and high-dose pulsed steroids for therapy. "
05/01/2015 - "Steroids and immunosuppression have a definite place in children with proven vasculitis, but their role in focal arteriopathies is less clear. "
01/01/2014 - "Treatment of the different type of vasculitis mainly relies on steroids and immunosuppressive drugs. "
09/01/1996 - "One hundred per cent of patients with renal vasculitis who started plasma exchange within one month of disease onset and 58% of cases with IRPGN had significant improvement in renal function. "
01/01/2015 - "Plasma exchange was effective in patients with severe AKI secondary to vasculitis. "
01/01/2010 - "Plasma exchange is effective in patients with severe ARF secondary to vasculitis. "
01/01/2008 - "Plasma exchange is effective in patients with severe ARF secondary to vasculitis. "
04/01/2011 - "We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. "
02/01/2016 - "His vasculitis improved three weeks after treatment with antiretroviral medications. "
03/01/2012 - "The Birmingham Vasculitis Activity Score decreased only after treatment with RTX (from a mean ± SD of 11.9 ± 5.4 at baseline to 7.1 ± 5.7 at month 2; P < 0.001) up to month 24 (4.4 ± 4.6; P < 0.0001). "
01/01/2011 - "After treatment, overall clinical response of vasculitis (75% vs 83%) and sustained virological response (40% vs 64%; p = 0.3) were similar between cases and controls, except for higher complete clinical response (42% vs 73%; p = 0.05) in controls. "
12/01/2010 - "After treatment, GI+ and GI- patients had similar rates of overall clinical response of the vasculitis and immunological and virological responses. "
01/01/2010 - "Two vasculitis syndrome patients exhibited persistent symptoms and abnormal blood tests after treatment with conventional therapies. "
01/01/2014 - "There may be an excess mortality in those transplanted less than 1 year after induction of vasculitis remission, so it is probably wise to wait for this period before proceeding with the graft. "
08/01/2010 - "Whether outcomes following renal transplant may be influenced by the underlying diagnosis of vasculitis merits further study."
12/01/1980 - "Excluding vasculitides, renal transplants, and outside cases with inadequate clinical data, 110 were selected for further study. "
05/01/2015 - "Banff-grading after 7 days showed significantly reduced scores for tubulitis and vasculitis in the grafts of these recipients. "
01/01/2014 - "Relapse of vasculitis posttransplant appears to be lower in the modern era of transplant induction. "
|4.||Drug Therapy (Chemotherapy)
04/01/2015 - "Role of Brain Perfusion SPECT with 99mTc HMPAO in the Assessment of Response to Drug Therapy in Patients with Autoimmune Vasculitis: A Prospective Study."
01/01/2012 - "Should our patient have experienced refractory vasculitis, we would have instituted systemic chemotherapy to treat the underlying malignancy."
06/01/2009 - "We undertook a systematic literature review to assess the evidence for using drug therapies in vasculitis. "
06/01/2009 - "Pharmacotherapy of vasculitis."
04/01/2005 - "Drug therapy is a common cause of limited forms of vasculitis and may enhance our understanding of the mechanism of these diseases. "
07/01/2012 - "We describe a case of "refractory" urticarial vasculitis in which the symptoms improved after plasmapheresis treatment. "
01/01/2012 - "A recent meta-analysis took into account 28 randomized clinical trials studying therapeutic interventions in adult vasculitis with renal involvement, six of them scheduling plasmapheresis as adjunctive therapy to immune suppressant drugs. "
07/01/2012 - "We suggest that plasmapheresis be considered as an option in patients with severe or treatment-resistant urticarial vasculitis."
07/01/2012 - "Plasmapheresis in a patient with "refractory" urticarial vasculitis."
07/10/2011 - "Plasmapheresis, completed as part of combined immunosuppressive treatment, resulted in remarkable improvements in patients with anti-cytoplasmic antibody-associated vasculitis. "