Vascular Headaches (Vascular Headache)

Secondary headache disorders attributed to a variety of cranial or cervical vascular disorders, such as BRAIN ISCHEMIA; INTRACRANIAL HEMORRHAGES; and CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS.

Also Known As:

Networked: 180 relevant articles (8 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Migraine Disorders (Migraine)
2.	Headache (Headaches)
3.	Pain (Aches)
4.	Tension-Type Headache (Tension Headache)
5.	Sleep Apnea Syndromes (Sleep Apnea)

Experts

1.	Messlinger, K: 2 articles (06/2003 - 04/2002)
2.	Strecker, T: 2 articles (06/2003 - 04/2002)
3.	Bao, Hong-Guang: 1 article (01/2022)
4.	Ge, Chun: 1 article (01/2022)
5.	Li, Jun: 1 article (01/2022)
6.	Liu, Yun-Xin: 1 article (01/2022)
7.	Xu, Chu: 1 article (01/2022)
8.	Zhang, Xue: 1 article (01/2022)
9.	Zhao, Zheng: 1 article (01/2022)
10.	Zhu, Yu-Bing: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vascular Headaches:

1.	Pizotyline (BC 105)IBA 01/01/1972 - "Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches." 01/01/2022 - "Pizotifen, a 5-HT2 receptor antagonist, is currently used in the prevention of vascular headaches. " 11/01/1969 - "[Tests of BC 105 in 20 cases of vascular headache]." 01/01/1974 - "A cooperative study on the clinical aspects of migraine and vascular headache and their response to sandomigran." 10/01/1977 - "These properties, and the well-documented effect of pizotifen in migraine, could make it an alternative in treating patients suffering from the often seen combination of vascular headache/depression."
2.	Ergot AlkaloidsIBA 01/01/1990 - "Since the ergot alkaloids possess a similar profile of drug activity, it is suggested that drugs useful in the treatment of acute vascular headaches may share a similar mechanism of action." 12/01/1988 - "Ergot alkaloids block neurogenic extravasation in dura mater: proposed action in vascular headaches." 08/01/1992 - "Moskowitz argues that blockade of neural transmission and the neurogenic inflammatory response provides a mechanism by which sumatriptan and ergot alkaloids alleviate vascular headaches. "
3.	Methylergonovine (Methergine)FDA LinkGeneric 07/01/1997 - "Methylergonovine maleate (Methergine), an ergot derivative with vasoconstrictive properties, has been cited as an effective treatment for vascular headaches. "
4.	Methysergide (Sansert)FDA Link 01/01/1965 - "CLINICAL STUDIES ON THE TREATMENT OF VASCULAR HEADACHES, A PROGRESS REPORT ON METHYSERGIDE (SANSERT)." 05/05/1967 - "[Experience with methysergide in 48 cases of vascular headache]." 10/01/1963 - "USE OF METHYSERGIDE IN THE TREATMENT OF EXTRACRANIAL VASCULAR HEADACHE." 01/01/1962 - "Prophylaxis of frequent vascular headache with methysergide." 03/01/1961 - "Evaluation of UML-491 in the treatment of vascular headaches. "
5.	Ergotamine (Ergotamine Tartrate)FDA LinkGeneric 02/01/1966 - "A study of a non-ergotamine agent in the office treatment of vascular headache." 08/01/2013 - "Ergotamine is used to abort or prevent vascular headache. " 01/01/2012 - "Ergotamine is a well known pharmacological remedy applied in neurology (treatment of vascular headache) and in obstetrics (abortive remedy, uterus atony). " 06/01/2007 - "Ergotamine has been used for therapeutic purposes since the 1950s, usually to treat vascular headache. " 04/01/1963 - "Ergotamine tartrate in the treatment of vascular headaches."
6.	Histamine (Histamine Dihydrochloride)FDA Link 04/01/1980 - "The i.v. histamine infusion test is a useful model for the study of experimental vascular headache." 10/01/1950 - "[Endovenous histamine in treatment of vascular headache]." 11/01/1966 - "Intradermal histamine therapy of vascular headache." 01/01/1951 - "Chronic vascular headache treated by intense histamine therapy; therapeutic and side-effects as well as mechanism of histamine treatment." 08/11/1980 - "[Skin tests, blood histamine level and eosinophilia in vascular headache]."
7.	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/01/2003 - "The role of nitric oxide in vascular headache." 09/01/1995 - "Nitric oxide (NO) and the dura mater are implicated in the pathogenesis of vascular headache. " 04/01/1995 - "The nitric oxide hypothesis of migraine and other vascular headaches." 05/01/1994 - "Nitric oxide is a key molecule in migraine and other vascular headaches." 12/21/2001 - "Nitric oxide (NO) is a key molecule in vascular headaches and the dura mater has been implicated as a tissue where vascular headache develops. "
8.	Oral ContraceptivesIBA 01/01/1990 - " While the study does not explain the correlation between low-dose oral contraceptives and vascular headaches, it does point out the risk associated with oestrogen." 01/01/1990 - "The relationship between vascular headaches and low-dose oral contraceptives." 01/01/1983 - "Vascular headaches and oral contraceptives." 10/01/1966 - "Vascular headaches and oral contraceptives." 06/04/1966 - "Vascular headaches and oral contraceptives."
9.	Analgesics (Analgesic Drugs)IBA 08/01/1993 - "Analgesic effect of vascular-headache by the TTDB and placebo were as follows: Effective rate of TTDB was up to 80%, significantly higher than that of placebo. " 08/01/1993 - "[Sequential trial on analgesic effect of vascular headache by toutong dibi ye]." 04/01/1977 - "Analgesic drugs as alternatives to ergotamine in the treatment of vascular headache." 01/01/2005 - "The incidence of naratriptan-induced adverse effects in the CNS is low and it is not an analgesic for pain other than that of vascular headache. " 09/01/1976 - "More prevalent is the type of vascular headache associated with giant cell arteritis, which is severe and resistant to any form of analgesic except the strongest narcotics. "
10.	Calcitonin Gene-Related PeptideIBA 02/01/2003 - "Calcitonin gene-related peptide (CGRP) is involved in the underlying pathophysiology of all vascular headaches, including migraines. " 11/01/2002 - "Nitric oxide (NO) and calcitonin-gene-related peptide (CGRP) are implicated in the pathophysiology of vascular headaches. " 06/01/2003 - "Nitric oxide (NO) and calcitonin gene-related peptide (CGRP), potent vasodilators in the meninges,may be involved in the pathophysiology of vascular headaches such as migraine pain. " 04/01/2002 - "This study addresses possible interactions of the vasodilators nitric oxide (NO), calcitonin gene-related peptide (CGRP) and prostaglandins, which may be implicated in the generation of vascular headaches. "

Therapies and Procedures

1.	Psychology Biofeedback (Biofeedback) 03/01/1983 - "Vascular headache patients low in absorption were significantly improved after biofeedback training. " 03/01/1983 - "Vascular headache patients high in absorption were significantly improved following relaxation training, but not after biofeedback training. " 09/01/1991 - "The clinical utility of Tellegen's Absorption Scale was examined using a sample of 32 chronic vascular headache patients drawn from a larger treatment study investigating the efficacy of thermal biofeedback with vascular headache. " 06/01/1990 - "This study investigates the use of biofeedback, relaxation and psychotherapy on five patients with severe, vascular headaches that occurred during the course of pregnancy. " 03/01/1989 - "Two studies of the potential mechanisms of action in the thermal biofeedback treatment of vascular headache."
2.	Therapeutics 09/01/2000 - "SI17 therapy is better for the treatment of vascular headache. " 01/01/1988 - "[Present knowledge of pathogenesis, pathophysiology, clinical aspects and therapy of vascular headaches]." 01/01/1965 - "[ANTISEROTONIN DRUGS IN THE THERAPY OF VASCULAR HEADACHES]." 05/23/1959 - "[Pathogenesis & therapy of vascular headache]." 04/01/1991 - "The correct significance of these equivocal MRI findings of possible venous sinus thrombosis must be understood so that unnecessary and potentially harmful therapies are not employed, and so that appropriate management of what may otherwise be a typical vascular headache syndrome may be undertaken."
3.	Ganglionectomy 09/01/1998 - "The authors conclude that: 1) patients who suffer from chronic occipital pain after having sustained injury obtain worthwhile benefit from microsurgical C-2 ganglionectomy; 2) patients suffering from migraine, tension, and vascular headaches involving the occipital area are most often not helped by this operation; and 3) terms such as "shock," "electric," "shooting," "jabbing," and "sharp" used to describe occipital pain predict a favorable pain outcome following a C-2 ganglionectomy."
4.	Drug Therapy (Chemotherapy) 05/01/1986 - "Long-term drug therapy is effective for most patients with vascular headaches. "
5.	Contraindications 01/01/1983 - "A history of vascular headache is therefore a contraindication to the use of these medications." 07/14/1975 - "Vascular headaches - contraindication to oral contraceptives." 10/01/1991 - " The simple, user-friendly, and flexible flow chart contains relative contraindications: age over 35 in heavy smokers, migraine or severe vascular headache, age over 45, previous cholestasis during pregnancy, hypertension, smoking, diabetes mellitus, long term immobilization, abnormal vaginal bleeding, gallbladder disease, impaired liver function, acute infectious mononucleosis, and use of rifampin or anticonvulsants."