Vanilmandelic Acid (Vanillylmandelic Acid)

A 3-O-methyl ether of 3,4-dihydroxymandelic acid. It is an end-stage metabolite of CATECHOLAMINES; EPINEPHRINE; and NOREPINEPHRINE.

Also Known As:

Vanillylmandelic Acid; 4-Hydroxy-3-Methoxymandelic Acid; 4 Hydroxy 3 Methoxymandelic Acid; Acid, 4-Hydroxy-3-Methoxymandelic; Acid, Methoxyhydroxymandelic; Acid, Vanillylmandelic; Acid, Vanilmandelic; Methoxyhydroxymandelic Acid; Benzeneacetic acid, alpha,4-dihydroxy-3-methoxy-

Networked: 393 relevant articles (3 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Mandelic Acids
      - Vanilmandelic Acid: 393
        isovanilmandelic acid
  - Carbocyclic Acids
    - Mandelic Acids
      - Vanilmandelic Acid: 393
        isovanilmandelic acid

Experts

1.	Iijima, Kazumoto: 3 articles (07/2021 - 01/2015)
2.	Barco, Sebastiano: 3 articles (06/2014 - 07/2012)
3.	Cangemi, Giuliana: 3 articles (06/2014 - 07/2012)
4.	Melioli, Giovanni: 3 articles (12/2013 - 01/2005)
5.	Hasegawa, Daiichiro: 2 articles (07/2021 - 08/2016)
6.	Kosaka, Yoshiyuki: 2 articles (07/2021 - 08/2016)
7.	Mori, Takeshi: 2 articles (07/2021 - 08/2016)
8.	Nishimura, Noriyuki: 2 articles (07/2021 - 08/2016)
9.	Yamamoto, Nobuyuki: 2 articles (07/2021 - 08/2016)
10.	Cho, Hee Won: 2 articles (06/2021 - 10/2018)

Related Diseases

1.	Hypertension (High Blood Pressure) 01/01/1972 - "[Dynamic study of the excretion of vanilmandelic acid in juvenile hypertension]." 07/01/2023 - "Four variables including age ≤ 35 years, hypertension, 24 h urinary output of urinary vanillylmandelic acid (VMA) ≥ 100 umol/24 h and urinary 17-ketosteroide (17 KS) ≤ 50 umol/24 h levels were independently associated with PHT PPGLs in the logistic regression analysis and were included in the nomogram. " 09/01/2005 - "A 14-year-old girl presented with uncontrolled hypertension, high urinary vanillylmandelic acid level and a 5 x 6 cm mass at the right renal hilum. " 01/01/1985 - "A statistically significant correlation between vanilmandelic acid excretion and tumour mass persisted in groups IA (sustained hypertension without attacks), IB (sustained hypertension with attacks), and II (paroxysmal hypertension) but not in group III (miscellaneous patients). " 04/21/1978 - "3-Methoxy-4-hydroxyphenylglycol in cerebrospinal fluid and vanillylmandelic acid in urine of humans with hypertension."
2.	Depressive Disorder (Melancholia) 03/01/1966 - "[Study of the urinary excretion of vanillylmandelic acid during depressive syndromes, maniacal states and mixed states]." 01/01/1971 - "[Excretion of vanilmandelic acid in depressive syndromes of various etiology]." 06/01/1986 - "Thirteen patients with endogenous depression, compared to 25 normal controls, had a significantly greater ratio of the urinary excretion of norepinephrine plus its metabolite normetanephrine to either the sum of the two urinary norepinephrine metabolites 3-methoxy-4-hydroxyphenylglycol plus vanillylmandelic acid or to the sum of urinary norepinephrine and all of its metabolites. " 06/01/1986 - "As urinary levels of norepinephrine and normetanephrine are derived from an extraneuronal metabolic pathway, while levels of 3-methoxy-4-hydroxyphenylglycol and vanillylmandelic acid are more representative of total norepinephrine metabolism, these results suggest that there is a shift in endogenous depression to extraneuronal metabolic pathways for norepinephrine and its metabolites." 09/01/1995 - "In addition to the animal experiments, the following data of six patients with an "endogenous" depression were recorded over a period of several weeks: the clinical findings by means of the Hamilton Depression Rating Scale, and the excretion of normetanephrine and of vanillylmandelic acid (VMA) in the urine before, during and after treatment with imipramine. "
3.	Osteoporosis 10/01/2000 - "The type of lesion did not rise important differential diagnosis issues, excepting the cases with unique osteolytic lesion or diffuse osteoporosis, where the rest of the data and the elevated urine vanilmandelic acid helped to establishing the diagnosis. "
4.	Pheochromocytoma 05/08/2023 - "Notably, luminescent sensing studies reveal that Ln-MOF 1 with prominent fluorescence properties can perform in highly sensitive and selective sensing of vanillylmandelic acid (VMA) in aqueous systems (KSV = 562.8 L·mol-1; LOD = 4.6 × 10-4 M), which can potentially establish a detection platform for the diagnosis of pheochromocytoma via multiquenching mechanisms. " 01/01/2023 - "Elevated 24-h urinary vanillylmandelic acid levels can aid in the diagnosis of pheochromocytomas. " 08/05/2022 - "The high level of 24-hour urinary vanillylmandelic acid and abdominal computed tomography findings supported the diagnosis of pheochromocytoma. " 01/01/2021 - "In humans, urinary vanillylmandelic acid (VMA) is part of a pheochromocytoma biochemical diagnostic profile, whereas its diagnostic accuracy is currently unknown in dogs with pheochromocytoma. " 06/01/2020 - "By elaborately tailoring the biosensor's structure and surface areas, the tunable Eu-ZnMOF is developed with remarkably enhanced response slope within the "optimized useful detection window," enabling it to serve as a powerful signal amplifier (87.2-fold increase) for discriminating the small concentration variation of urinary vanillylmandelic acid (an early pathological signature of pheochromocytoma) within only three times between healthy and diseased subjects. "
5.	Neuroblastoma 06/01/2014 - "Urinary homovanillic and vanillylmandelic acid in the diagnosis of neuroblastoma: report from the Italian Cooperative Group for Neuroblastoma." 02/01/2014 - "Development of a new biochemical test to diagnose and monitor neuroblastoma in Vietnam: homovanillic and vanillylmandelic acid by gas chromatography-mass spectrometry." 11/01/1999 - "Screening programs using urinary vanillylmandelic acid have detected neuroblastomas in early infancy with some success. " 05/01/1999 - "During preparation of this manuscript another case of bladder dome neuroblastoma was detected by urinary vanillylmandelic acid screening of 6-month-old infants for neuroblastoma in Japan. " 05/01/1998 - "The relationship between homovanillic/vanillylmandelic acid ratios and prognosis in neuroblastoma."

Related Drugs and Biologics

1.	Norepinephrine (Noradrenaline)
2.	Catecholamines
3.	Epinephrine (Adrenaline)
4.	Normetanephrine
5.	Dopamine beta-Hydroxylase
6.	Catechol O-Methyltransferase (Methyltransferase, Catechol)
7.	Homovanillic Acid
8.	Dopamine (Intropin)
9.	Acids
10.	Phosphopyruvate Hydratase (Enolase)

Related Therapies and Procedures

1.	Therapeutics
2.	Length of Stay
3.	Drug Therapy (Chemotherapy)
4.	Sodium-Restricted Diet (Diet, Sodium Restricted)
5.	Diet Therapy (Therapy, Diet)