Vanadates (Orthovanadate)

Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects.

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Networked: 512 relevant articles (30 outcomes, 56 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fukunaga, Kohji: 7 articles (01/2018 - 08/2002)
2.	Treviño, Samuel: 6 articles (05/2021 - 01/2016)
3.	Hasegawa, Yu: 6 articles (03/2012 - 09/2003)
4.	Sakurai, Hiromu: 6 articles (03/2008 - 05/2002)
5.	González-Vergara, Enrique: 5 articles (01/2022 - 01/2016)
6.	Sánchez-Lara, Eduardo: 4 articles (03/2019 - 01/2016)
7.	Olopade, James O: 4 articles (01/2019 - 09/2010)
8.	Ehrlich, H Paul: 4 articles (01/2017 - 05/2003)
9.	Kordowiak, Anna M: 4 articles (12/2011 - 05/2005)
10.	Kawano, Takayuki: 4 articles (09/2006 - 08/2002)

Related Diseases

1.	Neoplasms (Cancer) 12/15/1992 - "Vanadyl ion (+4 oxidation state) has been shown to be an effective agent for chemoprotection of cancers in animals. " 10/01/2021 - "Herein, we present a vanadyl nanocomplex, which simultaneously serves as a photothermal agent (PTA) and an immunogenic cell death (ICD) inducer to enhance the anti-tumor immunity of PTT. " 08/01/2017 - "Furthermore, this redox active vanadyl complex altered the redox homeostatsis of many human cancer cell lines significantly. " 01/01/2012 - "Menadione : sodium orthovanadate combination eliminates and inhibits migration of detached cancer cells." 10/01/2002 - "The results obtained also point to vanadate as a possible chemotherapic in the use of multidrug-resistant tumors."
2.	Insulin Resistance 06/03/1991 - "Vanadate administration caused a shift to left in this correlation suggesting improvement in insulin sensitivity." 06/01/1992 - "The present study examined therefore whether the effects of vanadate could be attributed to a direct correction of the severe insulin resistance of these animals. " 12/01/2002 - "Effect of acute and short-term administration of vanadyl sulphate on insulin sensitivity in healthy active humans." 06/01/1992 - "Oral vanadate decreases muscle insulin resistance in obese fa/fa rats." 01/01/2018 - "Pharmacological and Toxicological Threshold of Bisammonium Tetrakis 4-(N,N-Dimethylamino)pyridinium Decavanadate in a Rat Model of Metabolic Syndrome and Insulin Resistance."
3.	Hyperglycemia 07/01/2006 - "The results of the present study indicate that vanadate produced marked contraction in the normal urinary bladder rings and this contraction was significantly enhanced by hyperglycemia. " 07/01/2006 - "Hyperglycemia significantly potentiated the response of bladder rings to vanadate. " 03/01/2000 - "The contribution of gluconeogenesis to hyperglycemia in non-obese diabetic (NOD) mice has been investigated using oral vanadate administration. " 11/01/1994 - "With an identical oral vanadate regimen of 0.25 mg/mL, the ability to sustain pregnancy to term was reduced by 30% and 90% for the nondiabetic and diabetic groups, respectively, and by 84% and 100% for these groups at a dose of 0.50 mg/mL. Although the blood vanadate concentrations were an order of magnitude higher in diabetic animals treated with vanadate than in nondiabetic animals under an identical vanadate treatment, oral vanadate treatments had no measurable effects in ameliorating hyperglycemia in these diabetic pregnant animals. " 10/01/1994 - "Relationship between reduction in food intake and amelioration of hyperglycemia by oral vanadate in STZ-induced diabetic rats."
4.	Polydipsia 03/01/1992 - "Similarly, in contrast to the normalizing effect of vanadyl in drinking water, vanadyl by gavage had only a minimal influence on diabetes associated hyperphagia and polydipsia. " 02/01/1994 - "In diabetic animals, vanadyl treatment significantly alleviated or prevented the occurrence of hyperglycaemia, hypoinsulinaemia, hyperphagia, polydipsia, hyperlipidaemia, or cataract formation, but the slower body weight gain was not improved. " 10/01/1994 - "By the 4th day of vanadate treatment of diabetic rats, there was reversal of polyuria, polydipsia and hyperglycemia with no change in acid-base status. " 01/01/1995 - "After the first month of treatment U-83836E improved significantly the protective effect of vanadate alone on polydipsia and polyuria, but more efficiently on hyperglycemia and glycosuria. " 09/01/1994 - "At subsequent steps, U-83836E significantly improved the protective effect of vanadate alone on polydipsia and polyuria, but especially on hyperglycemia and glycosuria. "
5.	Cataract (Cataracts) 05/01/1993 - "Cataract development was entirely suppressed in vanadyl-treated compared to untreated, diabetic rats. " 02/01/1994 - "In diabetic animals, vanadyl treatment significantly alleviated or prevented the occurrence of hyperglycaemia, hypoinsulinaemia, hyperphagia, polydipsia, hyperlipidaemia, or cataract formation, but the slower body weight gain was not improved. " 03/01/2005 - "It may be concluded that vanadate at lowered doses administered in combination with Trigonella was the most effective in controlling the altered glucose metabolism and antioxidant status in diabetic lenses, these being significant factors involved in the development of diabetic complications, that reflects in the reduced lens opacity." 04/01/1983 - "Tellurite ion offered only 20% protection, while ferrous, zinc, lead, chromic, molybdate, tungstate, and vanadate ions provided no protection against selenium-induced cataract. " 05/01/1993 - "Thus, vanadyl treatment was antioxidant in terms of cataract formation and reduced glutathione concentration in liver homogenates, pro-oxidant by reason of iron-stimulated TBARS formation and inconclusive with respect to glutamine synthetase activity. "

Related Drugs and Biologics

1.	Sodium
2.	Vanadates (Orthovanadate)
3.	Glucose (Dextrose)
4.	Insulin (Novolin)
5.	Vanadium
6.	Drinking Water
7.	Ions
8.	U 78517F
9.	Proteins (Proteins, Gene)
10.	Edetic Acid (EDTA)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Lenses
4.	Drug Therapy (Chemotherapy)
5.	Oral Administration