|3.||Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis)
|1.||Rosenbaum, James T: 50 articles (10/2015 - 09/2002)|
|2.||Foster, C Stephen: 40 articles (12/2015 - 01/2002)|
|3.||Chan, Chi-Chao: 38 articles (08/2015 - 03/2002)|
|4.||Dick, Andrew D: 31 articles (11/2015 - 08/2005)|
|5.||Caspi, Rachel R: 31 articles (08/2015 - 03/2002)|
|6.||Heiligenhaus, Arnd: 30 articles (12/2015 - 07/2002)|
|7.||Nussenblatt, Robert B: 29 articles (10/2015 - 03/2002)|
|8.||Mochizuki, Manabu: 28 articles (10/2014 - 01/2002)|
|9.||Heinz, Carsten: 25 articles (12/2015 - 07/2002)|
|10.||Yang, Peizeng: 25 articles (03/2015 - 03/2002)|
|1.||infliximab (Remicade)FDA Link
01/01/2014 - "Infliximab induces a high rate of complete clinical remission in recalcitrant uveitis and is well tolerated by most patients."
01/01/2012 - "Infliximab (INF) has been shown to be beneficial in treating refractory uveitis, however, no data exist on optimal dosing and the efficacy of higher dosing. "
03/01/2013 - "Relief of uveitis attacks and extraocular manifestations by infliximab therapy significantly improved the HR-QoL and VR-QoL in patients with BU."
07/01/2011 - "By the 2-month follow-up, the frequency of uveitis attacks involving the posterior segment and the BDCAF scores were significantly improved compared to the 2 months before introducing infliximab. "
08/01/2005 - "The results of this trial suggest that infliximab is effective in suppressing the occurrence of uveitis attacks, has a corticosteroid-sparing effect, and has favorable implications for the visual prognosis of patients with resistant Behçet's uveitis."
|2.||Cyclosporine (Ciclosporin)FDA LinkGeneric
02/01/1993 - "The uveitis markedly improved with ciclosporin A therapy. "
12/01/2002 - "Cyclosporine (CsA), a widely used immunosuppressive drug, is an effective treatment of sight-threatening posterior idiopathic uveitis. "
07/30/1983 - "Cyclosporin A seems to be effective treatment for selected patients with severe bilateral uveitis of non-infectious aetiology."
07/01/1998 - "Cyclosporin A therapy is effective and safe in the medium term, if closely monitored, in refractory non-infectious childhood uveitis."
01/01/2009 - "Uveitis improved and urine β2-MG normalized with low dose systemic predonisolone and cyclosporin A. "
|3.||adalimumab (Humira)FDA Link
10/01/2013 - "Adalimumab was effective in most patients in the initial control of acute inflammatory activity in children with refractory uveitis, although therapy appears to become less effective in the long term."
04/01/2011 - "Cox regression analysis did not show statistically significant differences between the two groups with regard to time to achieve remission and time to steroid discontinuation, whereas a higher probability of uveitis remission on adalimumab during the time of treatment was shown (Mantel-Cox χ2=6.83, P<0.001). "
01/01/2013 - "Even if limited to a relatively small group, our study suggests a better efficacy of Adalimumab when used as first anti-TNFα treatment in childhood chronic uveitis."
10/01/2013 - "The progressive course of the condition mandated considering other therapeutic measures; Adalimumab was chosen based on its purported efficacy for treatment of childhood uveitis and a favorable safety profile. "
01/01/2013 - "In long-term follow-up, Group 1 had higher probability of uveitis remission during the time of treatment on Adalimumab (median ±SE: 18 ±1.1 vs 4 ±0.6 months, CI 95%: 15.6-27.5 vs 2.7-5.2, Mantel-Cox χ(2)10.12, p<0.002). "
|4.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/01/2004 - "Tumor necrosis factor-alpha antagonists are promising but extremely expensive, and they may be more effective for rheumatologic and nonocular autoimmune disorders than for uveitis. "
02/01/1995 - "Although the findings do not support an important role for PAF in TNF alpha/IL-1 beta-induced uveitis, it cannot be ruled out that more intensive treatment with a specific and long-acting PAF-receptor antagonist might yield more positive results."
08/01/2006 - "Anti-TNF-alpha treatment was beneficial in a high percentage of patients with childhood uveitis refractory to standard immunosuppressive treatment. "
07/01/2007 - "Is anti-tumor necrosis factor therapy effective in reducing uveitis flares in patients with spondyloarthropathies?"
04/02/2007 - "Anti-TNFalpha was effective in treating uveitis in all 11 patients. "
|5.||Adrenal Cortex Hormones (Corticosteroids)IBA
12/01/2012 - "Addition of MMF as first-line therapy to corticosteroids in patients with acute uveitis associated with VKH disease leads to significant reduction in recurrences of uveitis and development of late complications and significantly improves visual outcome."
11/01/2008 - "Addition of anti-tubercular therapy to corticosteroids in uveitis patients with latent/manifest TB led to significant reduction in recurrences of uveitis."
09/01/1993 - "Injection of repository corticosteroids into the posterior sub-Tenon's space was effective in the treatment of CME secondary to uveitis. "
03/01/2007 - "The findings of the clinical studies showed, with use of Retisert, a reduction in the recurrence of uveitis, improvement in visual acuity, and a decreased need for adjunctive therapy with corticosteroids and immunosuppressant agents. "
10/01/1997 - "The purpose of this study was to evaluate the efficacy of a Coulomb Controlled Iontophoresis system (CCI) in the local delivery of corticosteroids for the treatment of uveitis. "
11/01/2008 - "Controlled studies which have led to the approval of drugs for JIA are needed for uveitis in order to have the most effective and safe therapy for children with uveitis, who do not respond to conventional therapy with local and systemic steroids."
07/01/2005 - "Steroids are the mainstay of treatment for leptospiral uveitis. "
06/01/2010 - "Remission of uveitis was achieved only after a combination therapy with 3 anti-tubercular agents and systemic steroids. "
01/01/2009 - "The uveitis treated with low dose of steroids and immunosuppressors, yielding a partial remission of the symptoms. "
07/01/2015 - "Six patients had previously been treated with steroids in the assumption of uveitis. "
|7.||TNFR-Fc fusion protein (etanercept)FDA Link
09/01/2004 - "Etanercept treatment significantly improved clinical uveitis scores at all examination points compared to the LPS injected animals. "
08/01/2005 - "The therapeutic efficacy of etanercept for chronic uveitis, a major complication of JIA, has not been evaluated so far. "
01/01/2008 - "These results suggest that etanercept may be effective for the treatment of CME secondary to uveitis, and they implicate TNF-a in the pathogenesis of uveitic CME."
08/01/2010 - "All patients responded well to their joint affliction, but developed endogenous uveitis for the first time after application of etanercept. "
01/01/2010 - "In placebo-controlled trials, the uveitis rate per 100 subject years (95% CI) for etanercept (8.6 (4.5 to 14.2)) was lower than that for placebo (19.3 (11.0 to 29.8), p = 0.03). "
|8.||Immunosuppressive Agents (Immunosuppressants)IBA
03/01/1996 - "Low-dose CSA used alone or in combination with other immunosuppressive agents is effective in achieving inflammatory control with a favorable visual outcome and provides a useful steroid-sparing strategy in the management of chronic endogenous uveitis. "
06/01/2009 - "MMF was safe and effective in controlling CMO and in reducing the uveitis relapse rate in patients not responding to traditional immunosuppressants. "
01/01/2014 - "We also discuss the stepwise approach to medical treatment of immune-mediated uveitis as well as the characteristics, safety, and efficacy of immunosuppressive agents used to treat ocular inflammatory disease. "
03/01/2013 - "This review describes the clinical studies and adverse effects of TNF-α blockers in the treatment of uveitis, and discusses the principle for clinical use of TNF-α blockers in synergy with other immunosuppressive agents."
01/01/2013 - "The purpose of this study was to describe comorbidities, healthcare costs, and resource utilization among patients with chronic non-infectious uveitis initiating corticosteroid, immunosuppressants, or biologics.In"
|9.||Methotrexate (Mexate)FDA LinkGeneric
06/01/2001 - "Methotrexate is effective in the treatment of chronic noninfectious uveitis that fails to respond to conventional steroid treatment. "
11/01/2013 - "Intraocular methotrexate can induce extended remission in some patients in noninfectious uveitis."
08/01/1998 - "The use of methotrexate decreased the severity of uveitis in six of seven patients and allowed for the discontinuation or reduction of corticosteroid drops."
01/01/2015 - "The aim of this study was to determine whether LEF improves flare rates of uveitis in JIA patients compared to preceding methotrexate (MTX) therapy. "
01/01/2014 - "This study will randomise 154 patients aged 2 to 18 years with active JIA-associated uveitis (despite methotrexate (MTX) treatment for at least 12 weeks). "
01/01/2009 - "We defined uveitis improvement as an increase in the best-corrected visual acuity or an objective and significant improvement in retinal exudates and/or haemorrhages, cystoid macular oedema (CME), and vitreous haze. "
01/01/2005 - "In experimental uveitis, MMF has been demonstrated to be highly effective in prevention of retinal destruction. "
08/01/2003 - "The retinal peptide gave rise to severe uveitis in the Lewis rat model of experimental autoimmune uveitis (EAU) and was effective in inducing oral tolerance, while the HLA peptide B27PD caused only mild disease, but it was at least equally effective in preventing uveitis by oral tolerance. "
03/01/2004 - "Retinal and choroidal biopsies are helpful in unclear uveitis of suspected infectious or malignant origin."
01/01/2015 - "The "classical" EAU model is induced by active immunization of mice with the retinal protein IRBP in adjuvant, and has proved to be a useful tool to study basic mechanisms and novel therapy in human uveitis. "
10/01/1997 - "Vitrectomy resulted in a marked improvement of visual acuity and clearing of uveitis."
12/01/2005 - "Our study suggests that vitrectomy may be both safe and effective for the management of vitreoretinal complications in Behçet's patients with persistent uveitis. "
08/01/2012 - "Safety and efficacy of small incision, sutureless pars plana vitrectomy for patients with posterior segment complications secondary to uveitis."
01/01/2010 - "To assess the effectiveness and safety of pars plana vitrectomy (PPV) in the management of chronic paediatric uveitis. "
04/01/1985 - "In the experience of the authors and several other investigators, pars plana lensectomy and vitrectomy by ultrasonic fragmentation not only improves vision but apparently causes a remission of uveitis. "
12/01/2010 - "To evaluate the efficacy of the novel ocular drug delivery using these novel micellar nanoparticles, uveitis was induced by intravitreal injection of the endotoxin within the rabbit eyes. "
12/01/1993 - "Used extensively in immunogenic studies Con A has been shown to induce uveitis after intravitreal injection in New Zealand Albino rabbits. "
01/01/2015 - "The local anti-inflammatory effects of AAV-delivered TatM013 were evaluated in an endotoxin-induced uveitis (EIU) mouse model after intravitreal injection of mice with an AAV2-based vector carrying either TatM013 fused to a secreted green fluorescent protein (GFP) tag (sGFP-TatM013) or GFP. "
11/01/2013 - "Intraocular delivery may be a potential alternative for the treatment of noninfectious uveitis, either by intravitreal injection or sustained-release drug-delivery systems, in doses of 50 µg/mL or lower."
01/01/2012 - "Intravitreal injection therapy in the treatment of noninfectious uveitis."
12/01/2010 - "Corticosteroid orbital floor injections resulted in control of active uveitis and visual acuity improvement in most children. "
01/01/1994 - "These results compare favourably with the results of systemic immunosuppression in patients with comparable patterns of uveitis, thus establishing the efficacy of orbital floor steroid injections and their potential value when systemic immunosuppression needs to be avoided."
11/01/2014 - "Periocular corticosteroid injections in uveitis: effects and complications."
07/01/2011 - "Endotoxin-induced uveitis was induced in rats by footpad injections. "
07/01/2010 - "A total of 178 injections were performed; no systemic side-effects, uveitis, or choroidal collateral vascular damage were observed. "
01/01/1990 - "This study confirmed that trabeculectomy predictably reduces the intraocular pressure to within the accepted normal range and that the pressure level below which the intraocular pressure could not be expected to fall was congruent to 14 mm/Hg. It also revealed that although some post operative abnormality was noted in two-thirds of the patients there were no long term problems which could be related to any operative or immediately post-operative complications, including shallow anterior chambers, uveitis and hyphaema. "
10/01/2015 - "Exclusion criteria included previous ocular surgery with the exception of clear cornea phaco or 1 previous trabeculectomy, uveitis, and vitreous in the anterior chamber. "
10/01/2013 - "A retrospective analysis of a single-surgeon series of 31 eyes of 25 patients with UG attending the Manchester Uveitis Clinic who had undergone 5FU-enhanced trabeculectomy between October 2002 and August 2010. "
09/01/2011 - "The eye of one patient was enucleated after failed trabeculectomies prior to referral to our uveitis centre. "
05/01/2004 - "Classical trabeculectomy is known to have a less favourable outcome in uveitis. "
07/01/2007 - "Visual function and uveitis improved after treatment in all patients. "
01/01/1989 - "The paper describes positive results after treatment of 15 patients with severe forms of uveitis by means of administering preparations into the portal vein of the eye. "
06/01/2014 - "Treatment of mice with IL-35 conferred protection from experimental autoimmune uveitis (EAU), and mice lacking IL-35 (p35 knockout (KO) mice) or defective in IL-35 signaling (IL-12Rβ2 KO mice) produced less Breg cells endogenously or after treatment with IL-35 and developed severe uveitis. "
05/01/2014 - "Outcomes of changing immunosuppressive therapy after treatment failure in patients with noninfectious uveitis."
07/01/2013 - "However, all patients developed acute uveitis in a period ranging from 4 to 7 weeks after treatment. "