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Uroporphyrinogen Decarboxylase (Uroporphyrinogen III Decarboxylase)

An enzyme that catalyzes the decarboxylation of UROPORPHYRINOGEN III to coproporphyrinogen III by the conversion of four acetate groups to four methyl groups. It is the fifth enzyme in the 8-enzyme biosynthetic pathway of HEME. Several forms of cutaneous PORPHYRIAS are results of this enzyme deficiency as in PORPHYRIA CUTANEA TARDA; and HEPATOERYTHROPOIETIC PORPHYRIA.
Also Known As:
Uroporphyrinogen III Decarboxylase; Carboxy-Lyase, Uroporphyrinogen; Decarboxylase, Uroporphyrinogen; Decarboxylase, Uroporphyrinogen III; Uroporphyrinogen Carboxy Lyase; Uroporphyrinogen Carboxy-Lyase; Uroporphyrinogen-III carboxy-lyase
Networked: 221 relevant articles (2 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Phillips, J D: 5 articles (09/2011 - 01/2001)
2. Méndez, Manuel: 4 articles (06/2013 - 02/2004)
3. Anderson, Karl E: 4 articles (12/2012 - 02/2002)
4. Phillips, John D: 4 articles (12/2011 - 10/2002)
5. Kushner, James P: 4 articles (12/2011 - 10/2002)
6. Morán-Jiménez, María-Josefa: 3 articles (06/2013 - 08/2010)
7. Lee, Chul: 3 articles (12/2012 - 03/2010)
8. Grady, James J: 3 articles (12/2012 - 03/2010)
9. Franklin, Michael R: 3 articles (12/2011 - 10/2002)
10. Badenas, C: 3 articles (09/2011 - 08/2008)

Related Diseases

1. Porphyria Cutanea Tarda
2. Hepatoerythropoietic Porphyria
3. Porphyrias
4. Hepatic Porphyrias (Hepatic Porphyria)
5. Erythropoietic Porphyria (Congenital Erythropoietic Porphyria)

Related Drugs and Biologics

1. Iron
2. DNA (Deoxyribonucleic Acid)
3. Hexachlorobenzene (HCB)
4. Tetrachlorodibenzodioxin (TCDD)
5. Cytochrome P-450 CYP1A1 (CYP1A1)
6. Liver Extracts
7. Genetic Markers (Genetic Marker)
8. Blood Group Antigens (Blood Groups)
9. Heme (Haem)
10. Porphyrins

Related Therapies and Procedures

1. Radiotherapy
2. Renal Dialysis (Hemodialysis)