Uridine Phosphorylase

An enzyme that catalyzes the transfer of ribose from uridine to orthophosphate, forming uracil and ribose 1-phosphate.

Also Known As:

5-Fluoro-2'-deoxyuridine Phosphorylase; 5 Fluoro 2' deoxyuridine Phosphorylase; Phosphorylase, 5-Fluoro-2'-deoxyuridine; Phosphorylase, Uridine; Uridine:orthophosphate alpha-D-ribosyltransferase

Networked: 69 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - Pentosyltransferases
        Pyrimidine Phosphorylases: 62
        Uridine Phosphorylase: 69
        deoxyuridine phosphorylase: 2
        human UPP1 protein
        human uridine phosphorylase-2

Experts

1.	Cao, Deliang: 6 articles (03/2016 - 04/2002)
2.	Pizzorno, Giuseppe: 5 articles (12/2011 - 04/2002)
3.	Wan, Laxiang: 4 articles (12/2011 - 04/2006)
4.	Yan, Ruilan: 3 articles (12/2011 - 04/2006)
5.	Ziemba, Amy: 2 articles (12/2011 - 06/2010)
6.	Zeng, Jianmin: 2 articles (06/2010 - 04/2006)
7.	Fukushima, Masakazu: 2 articles (01/2007 - 12/2002)
8.	Chen, Dijun: 1 article (01/2022)
9.	Gao, Jian: 1 article (01/2022)
10.	Han, Mingrui: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2011 - "Differential expression of uridine phosphorylase in tumors contributes to an improved fluoropyrimidine therapeutic activity." 01/01/2020 - "Uridine phosphorylase 1 (UPP1) has been reported as an oncogene in several malignancies. " 06/01/2010 - "Uridine phosphorylase (UPase) has been shown to be induced in various human and murine tumors and could potentially serve as a specific target for the modulation of tumor-selectivity of fluoropyrimidines. " 11/01/2006 - "Up-regulated expression of the uridine phosphorylase gene in human gastric tumors is correlated with a favorable prognosis." 06/15/2001 - "The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. "
2.	Colorectal Neoplasms (Colorectal Cancer) 11/02/1995 - "Using a mouse cDNA probe we have identified a human uridine phosphorylase cDNA clone from the cDNA library of a human colorectal tumor cell line, HCT116. " 05/01/2004 - "Expression of thymidylate synthase (TS) and the 5-fluorouracil (5-FU) metabolic enzymes, including dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT), thymidine phosphorylase (TP), and uridine phosphorylase (UP), has been reported to be associated with the sensitivity to 5-FU-based chemotherapy in colorectal cancer. " 01/01/2005 - "To predict the sensitivity of colorectal cancer to 5-FU, mRNA is extracted from surgically obtained cancer specimens and expression of thymidylate synthetase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), uridine phosphorylase (UP), es-nucleoside transporter (NT), and E2F1 are detected by real-time reverse transcription polymerase chain reaction (RT-PCR) (TaqMan). " 04/01/2006 - "In this study, we evaluated the correlation between sensitivity to 5-fluorouracil (5-FU) and the mRNA expression level of several 5-FU-related metabolic enzymes [thymidylate synthase, dihydropyrimidine dehydrogenase (DPD), thymidylate phosphorylase (TP), orotate phosphoribosyl transferase, and uridine phosphorylase] in primary colorectal cancer and synchronous liver metastases from ten patients to investigate how colorectal cancer acquires 5-FU resistance during liver metastases. " 01/01/2007 - "Activities of seven enzymes involved in nucleic acid metabolism--orotate phosphoribosyltransferase (OPRT), ribonucleotide reductase (RNR), thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, uridine phosphorylase and thymidine kinase (TK)--were measured in tumor and nontumor tissues from 28 patients who were operated on for colorectal cancers. "
3.	Neoplasm Metastasis (Metastasis) 10/01/2010 - "ER(-) cells express lower levels of superoxide dismutase, RalA binding protein, galectin-1, uridine phosphorylase 2, cellular retinoic acid-binding protein 1, S100 calcium binding protein A11, and nucleoside diphosphate kinase A or non-metastasis protein 23-H1 (nm23-H1). " 04/01/2006 - "In this study, we evaluated the correlation between sensitivity to 5-fluorouracil (5-FU) and the mRNA expression level of several 5-FU-related metabolic enzymes [thymidylate synthase, dihydropyrimidine dehydrogenase (DPD), thymidylate phosphorylase (TP), orotate phosphoribosyl transferase, and uridine phosphorylase] in primary colorectal cancer and synchronous liver metastases from ten patients to investigate how colorectal cancer acquires 5-FU resistance during liver metastases. " 12/01/2007 - "RNA was extracted from microdissected tumor cells of fixed and embedded specimens of resected liver metastases (94 cases) and analyzed by quantitative reverse-transcription polymerase chain reaction (RT-PCR) for thymidine phosphorylase, dihydropyrimidine dehydrogenase, thymidylate synthase, uridine phosphorylase, uridine/cytidine (monophospho)kinase, Bcl-2 related protein, Cyclin-D1, and Survivin expression. "
4.	Breast Neoplasms (Breast Cancer) 09/01/2006 - "Uridine phosphorylase in breast cancer: a new prognostic factor?" 06/15/2001 - "Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase." 04/15/2002 - "We have reported the elevation of uridine phosphorylase (UPase) in many solid tumors and the presence of a variant phosphorolytic activity in breast cancer tissues (M. " 11/01/2019 - "Uridine phosphorylase 1 (UPP1) is a protein-coding gene and has been detected that UPP1 was the higher expression in many solid malignancies, just as head and neck cancers, breast cancer, compared with paired normal tissue. " 04/01/2006 - "Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5'-deoxy-5-fluorouridine in breast cancer cells."
5.	Carcinoma (Carcinomatosis) 05/01/1984 - "At a nontoxic dose (50 microM), the two potent uridine phosphorylase inhibitors, benzylacyclouridine and benzyloxybenzylacyclouridine (BBAU), potentiated 5-fluoro-2'-deoxyuridine (FdUrd) growth inhibition of human pancreatic carcinoma (DAN) and, to a lesser extent, human lung carcinoma (LX-1) cells in culture. " 12/01/1969 - "Specific activities of uridine phosphorylase and uridine kinase in Ehrlich ascites carcinoma cells and 6-azauracil- and 6-azauridine-treated sublines in successive transplant generations." 04/01/1969 - "Uridine phosphorylase and uridine kinase activities of the Ehrlich ascites carcinoma." 08/01/2008 - "Experimental chemotherapy was performed using human gastric carcinoma xenografts, MKN-45 and TMK-1, to examine anticancer effects and gene expressions of fluoropyrimidine metabolism-related enzymes including thymidine phosphorylase (TP), thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyltransferase (OPRT), and uridine phosphorylase (UP). "

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	5-fluoro-2'-deoxyuridine
3.	5-(phenylselenenyl)acyclouridine
4.	Thymidine Phosphorylase
5.	Enzymes
6.	Thymidylate Synthase
7.	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)
8.	doxifluridine
9.	Transferases
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration