Uridine Phosphorylase

An enzyme that catalyzes the transfer of ribose from uridine to orthophosphate, forming uracil and ribose 1-phosphate.
Also Known As:
5-Fluoro-2'-deoxyuridine Phosphorylase; 5 Fluoro 2' deoxyuridine Phosphorylase; Phosphorylase, 5-Fluoro-2'-deoxyuridine; Phosphorylase, Uridine; Uridine:orthophosphate alpha-D-ribosyltransferase
Networked: 55 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Cao, Deliang: 5 articles (12/2011 - 04/2002)
2. Pizzorno, Giuseppe: 5 articles (12/2011 - 04/2002)
3. Wan, Laxiang: 4 articles (12/2011 - 01/2006)
4. Yan, Ruilan: 3 articles (12/2011 - 01/2006)
5. Ziemba, Amy: 2 articles (12/2011 - 06/2010)
6. Zeng, Jianmin: 2 articles (06/2010 - 04/2006)
7. Fukushima, Masakazu: 2 articles (01/2007 - 12/2002)
8. Sotnichenko, Sergey E: 1 article (08/2012)
9. Gabdulkhakov, Azat G: 1 article (08/2012)
10. Mikhailov, Al'bert M: 1 article (08/2012)

Related Diseases

1. Neoplasms (Cancer)
2. Colorectal Neoplasms (Colorectal Cancer)
11/02/1995 - "Using a mouse cDNA probe we have identified a human uridine phosphorylase cDNA clone from the cDNA library of a human colorectal tumor cell line, HCT116. "
05/01/2004 - "Expression of thymidylate synthase (TS) and the 5-fluorouracil (5-FU) metabolic enzymes, including dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT), thymidine phosphorylase (TP), and uridine phosphorylase (UP), has been reported to be associated with the sensitivity to 5-FU-based chemotherapy in colorectal cancer. "
04/01/2006 - "In this study, we evaluated the correlation between sensitivity to 5-fluorouracil (5-FU) and the mRNA expression level of several 5-FU-related metabolic enzymes [thymidylate synthase, dihydropyrimidine dehydrogenase (DPD), thymidylate phosphorylase (TP), orotate phosphoribosyl transferase, and uridine phosphorylase] in primary colorectal cancer and synchronous liver metastases from ten patients to investigate how colorectal cancer acquires 5-FU resistance during liver metastases. "
01/01/2005 - "To predict the sensitivity of colorectal cancer to 5-FU, mRNA is extracted from surgically obtained cancer specimens and expression of thymidylate synthetase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), uridine phosphorylase (UP), es-nucleoside transporter (NT), and E2F1 are detected by real-time reverse transcription polymerase chain reaction (RT-PCR) (TaqMan). "
01/01/2007 - "Activities of seven enzymes involved in nucleic acid metabolism--orotate phosphoribosyltransferase (OPRT), ribonucleotide reductase (RNR), thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, uridine phosphorylase and thymidine kinase (TK)--were measured in tumor and nontumor tissues from 28 patients who were operated on for colorectal cancers. "
3. Neoplasm Metastasis (Metastasis)
4. Carcinoma (Carcinomatosis)
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Fluorouracil (Carac)
2. Carbon Monoxide
3. 5-(phenylselenenyl)acyclouridine
4. Thymidine Phosphorylase
5. Thymidylate Synthase
6. Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)
7. Enzymes
8. doxifluridine
9. Transferases
10. Messenger RNA (mRNA)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Drug Therapy (Chemotherapy)
3. Transplants (Transplant)