|1.||Lazarowski, Eduardo R: 3 articles (07/2013 - 05/2003)|
|2.||Harden, T Kendall: 3 articles (07/2013 - 05/2003)|
|3.||Jacobson, Kenneth A: 2 articles (07/2013 - 12/2009)|
|4.||Barrett, Matthew O: 2 articles (07/2013 - 12/2009)|
|5.||Chen, Hui-Jin: 2 articles (12/2012 - 11/2012)|
|6.||Li, Wen-Juan: 2 articles (12/2012 - 11/2012)|
|7.||Qian, Long-Hua: 2 articles (12/2012 - 11/2012)|
|8.||Mao, Feng-Xia: 2 articles (12/2012 - 11/2012)|
|9.||Lakatoš, Boris: 1 article (05/2015)|
|10.||Sulová, Zdena: 1 article (05/2015)|
01/22/2015 - "The aim of the present study was to further explore whether UDPG, GDNF and/or memantine could promote corresponding self-repair of the subventricular zone (SVZ) and white matter (WM) in neonatal rats with ischemia-induced PVL. "
01/22/2015 - "Labeling with 5'-bromo-2'-deoxyuridine and immunofluorescent cell lineage markers after hypoxia-ischemia or oxygen-glucose deprivation (OGD) revealed that UDPG, GDNF and memantine each significantly increased glial progenitor cells and preoligodendrocytes (preOLs), as well as more differentiated immature and mature oligodendrocyte (OL), in both the SVZ and WM in vivo or in vitro. "
12/01/1978 - "On the contrary, an activating effect of suloctidil and (-)eburnamonine could be observed during the recovery after both hypoxia and hypoxia plus complete ischemia, papaverine being ineffective and UDP-glucose increasing the glycogen synthesis. "
01/22/2015 - "Treatment with UDP-glucose (UDPG), an endogenous agonist of G protein-coupled receptor 17 (GPR17) that may enhance endogenous self-repair potentiality, glial cell line-derived neurotrophic factor (GDNF), a neurotrophic factor associated with the growth and survival of nerve cells, and memantine, a noncompetitive antagonist of N-methyl-d-aspartate (NMDA) receptors that block ischemia-induced glutamate signal transduction, has been reported to achieve functional, neurological improvement in neonatal rats with PVL. "
07/01/1996 - "The UDPG/UDPAG ratio seems to reflect the nature and rate of tumor growth."
10/01/1989 - "Maximal depression (30% of saline control) or PRPP occurred in liver 6 hr after intravenous UDPG at 1000-2000 mg/kg. Enhanced levels of UDPG in plasma (half-life less than 10 min) and tumor was detected at 30 min after intravenous UDPG at 2000 mg/kg. There was no detectable increase in endogenous levels of UDPG in liver at this time, probably as a result of rapid metabolism of UDPG by liver. "
03/01/1987 - "However, the high level of PRPP in the tumors they carried was greatly affected by the UDPG infusion. "
10/01/1989 - "Liver was more sensitive than tumor to the 5-phosphoribosyl pyrophosphate (PRPP)-depleting effects of a single bolus intravenous injection of UDPG, since significantly lower levels of PRPP were found in liver, but not in tumor, at doses of 500-1000 mg/kg of UDPG. "
07/01/1996 - "A positive correlation was found between the UDPG/UDPAG ratio was from 1.73 in typical (benign) neoplasms to 6 or even higher in meningiomas with severe sings of malignancy (anaplastic meningiomas). "
|3.||Liver Diseases (Liver Disease)
03/10/1976 - "Statistically significant evidence was obtained of the efficacy of UDPG in acute and serious liver disease, and of the greater effectiveness of one of the two doses used. "
05/01/1973 - "[Open clinical experience with uridine-diphosphoglucose in icterigenous liver diseases of acute and chronic course]."
|4.||Periventricular Leukomalacia (Neonatal Cerebral Leukomalacia)
11/27/2012 - "Periventricular leukomalacia long-term prognosis may be improved by treatment with UDP-glucose, GDNF, and memantine in neonatal rats."
12/01/2012 - "To evaluate pathologically the effect of the single or combined application of UDP-glucose, GDNF and memantine on the improvement of white matter injury in neonatal rats with periventricular leukomalacia (PVL) under light and electron microscopy. "
11/27/2012 - "The therapeutic effects of UDP-glucose (UDPG), an endogenous agonist of GPR17 that may promote the self-repair of white matter, glial cell line-derived neurotrophic factor (GDNF), a neurotrophic factor correlated with the growth and survival of nerve cells, and memantine, an antagonist of NMDA receptors, were evaluated for functional improvement of neonatal rats with experimental periventricular leukomalacia (PVL). "
|5.||Astrocytoma (Pilocytic Astrocytoma)
04/01/2008 - "In the present study, the occurrence of receptor-promoted release of UDP-glucose was investigated, using 1321N1 human astrocytoma cells. "
04/01/2008 - "Our study demonstrates the occurrence of Ca2+ -dependent release of UDP-glucose from astrocytoma cells in response to a physiologically relevant stimulus, that is, a G-protein-coupled receptor agonist. "
04/01/2008 - "Thrombin-promoted release of UDP-glucose from human astrocytoma cells."
01/01/2006 - "Agonist-promoted release of ATP from 1321N1 astrocytoma cells also results in the release of UDP-glucose but, unlike fast hydrolysable ATP, UDP-glucose was hydrolysed at a markedly slow rate. "
05/01/2003 - "Mechanical stimulation of 1321N1 human astrocytoma cells by a change of medium resulted in an increase in extracellular levels of both ATP and UDP-glucose. "
|1.||Uridine Diphosphate Glucose (UDP Glucose)
|2.||Glial Cell Line-Derived Neurotrophic Factor (GDNF)
|4.||GTP-Binding Proteins (G-Protein)
|5.||N-Methyl-D-Aspartate Receptors (NMDA Receptors)
|7.||Glutamic Acid (Glutamate)
|9.||Uridine Diphosphate (UDP)