Urethral Neoplasms (Urethral Cancer)

Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Primary urethral carcinomas are rare and typically of squamous cells. Urethral carcinoma is the only urological malignancy that is more common in females than in males.

Also Known As:

Urethral Cancer; Cancer of the Urethra; Neoplasms, Urethral; Urethra Cancer; Urethra Neoplasms; Cancer, Urethra; Cancer, Urethral; Cancers, Urethra; Cancers, Urethral; Neoplasm, Urethra; Neoplasm, Urethral; Neoplasms, Urethra; Urethra Cancers; Urethra Neoplasm; Urethral Cancers; Urethral Neoplasm; Cancer of Urethra

Networked: 62 relevant articles (5 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Neoplasm Metastasis (Metastasis)
3.	Lung Neoplasms (Lung Cancer)
4.	Chest Pain (Chest Pains)
5.	Urinary Bladder Neoplasms (Bladder Cancer)

Experts

1.	Briganti, Alberto: 2 articles (01/2021 - 01/2020)
2.	Chun, Felix K H: 2 articles (01/2021 - 01/2020)
3.	Collà Ruvolo, Claudia: 2 articles (01/2021 - 01/2020)
4.	Karakiewicz, Pierre I: 2 articles (01/2021 - 01/2020)
5.	Kluth, Luis A: 2 articles (01/2021 - 01/2020)
6.	Nocera, Luigi: 2 articles (01/2021 - 01/2020)
7.	Saad, Fred: 2 articles (01/2021 - 01/2020)
8.	Shariat, Shahrokh F: 2 articles (01/2021 - 01/2020)
9.	Tian, Zhe: 2 articles (01/2021 - 01/2020)
10.	Wenzel, Mike: 2 articles (01/2021 - 01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Urethral Neoplasms:

1.	Morphine (MS Contin)FDA LinkGeneric 01/01/2011 - "Case 1 suffered serious back and epigastric pain arising from metastasis of lung cancer and Case 2 was not relieved right chest pain by costal metastasis from urethral cancer only by morphine. "
2.	Albumin-Bound Paclitaxel FDA Link 01/01/2014 - "This is the first case report to document the use and efficacy of nanoparticle albumin-bound-paclitaxel in the treatment of unresectable metastatic urethral cancer. "
3.	Prostate-Specific Antigen (Semenogelase)IBA 11/01/2000 - "The urethra-cancer distance correlated with each of the following preoperative factors: preoperative prostate-specific antigen (r = -0. " 09/13/2014 - "The scenarios included: chronic radiation proctitis, Prostate Specific Antigen (PSA) 'bounce', recurrence of cancer, urethral stricture, erectile dysfunction and depression or anxiety. "
4.	Drinking WaterIBA 09/01/1997 - "In both genders, we observed associations of high arsenic levels in drinking water with transitional cell carcinomas of the bladder, kidney, and ureter and all urethral cancers combined. "
5.	Carboplatin (JM8)FDA LinkGeneric 05/01/2017 - "Syndrome of Inappropriate Secretion of Antidiuretic Hormone Caused by Carboplatin After Switching from Cisplatin in a Metastatic Urethral Cancer Patient."
6.	Fluconazole (Zonal)FDA LinkGeneric 05/01/2006 - "Zonal location of cancer, distance to the urethra, cancer volume, Gleason grade and multicentricity were recorded; volume of cancer was measured using the grid-counting method. "
7.	Vasopressins (Vasopressin)IBA 05/01/2017 - "Syndrome of Inappropriate Secretion of Antidiuretic Hormone Caused by Carboplatin After Switching from Cisplatin in a Metastatic Urethral Cancer Patient."
8.	PalladiumIBA 08/01/2015 - "This report presents the utilization of a palladium interstitial implant and a review of the retrospective data published on the management of female urethral cancer. "
9.	MucinsIBA 01/01/2005 - "On histologic examination, the female para-urethral cancers were divided into five cases of mucin-producing-type adenocarcinoma and one case of clear cell-type adenocarcinoma. "
10.	Cisplatin (Platino)FDA LinkGeneric 05/01/2017 - "Syndrome of Inappropriate Secretion of Antidiuretic Hormone Caused by Carboplatin After Switching from Cisplatin in a Metastatic Urethral Cancer Patient."

Therapies and Procedures

1.	Radiotherapy 05/01/2018 - "Novel Treatment Setup for Urethral Cancer: Use of the Prone Technique for Radiotherapy of the Penis." 06/01/2020 - "This report details organ-preserving treatment for a distal penile urethral cancer using definitive radiation therapy (RT). " 10/01/2018 - "Optimizing the Role of Surgery and Radiation Therapy in Urethral Cancer Based on Histology and Disease Extent." 10/01/1993 - "We treated 5 women with stage C urethral cancer by wide local excision with or without concomitant radiation therapy, while preserving the bladder. " 01/01/1986 - "[Radiotherapy of penis and urethral cancers]."
2.	Brachytherapy 06/01/2015 - "Intraluminal brachytherapy seems to be an effective novel treatment for male urethral cancer. " 02/01/2016 - "High-dose-rate interstitial brachytherapy for female peri-urethral cancer." 05/01/1997 - "Although we prefer interstitial implantation as the boost technique for women with urethral cancer, high dose rate brachytherapy is a reasonable option for medically inoperable patients. " 01/01/1994 - "[Brachytherapy in cancer of the urethra]." 07/01/1978 - "[Curietherapy technic in women with urethral cancer]."
3.	Therapeutics 11/01/2016 - "Management of Proximal Primary Urethral Cancer: Should Multidisciplinary Therapy Be the Gold Standard?" 01/01/2021 - "Despite higher rates of multimodal therapy, and despite matching for stage disadvantage, female subjects with urethral cancer exhibited higher CSM." 01/01/2020 - "We found preliminary evidence that multimodal therapy, more commonly used in recent years, was of benefit in patients with primary urethral cancer. " 01/01/2018 - "Patients with early stage urethral cancers do well with single modality therapy, whereas patients who present with advanced cancers may benefit from combined modality therapy. " 11/01/2019 - "Keywords used were: for upper tract urothelial carcinoma (UTUC): endoscopic, ureteroscopic/percutaneous management, laser ablation; for urothelial bladder cancer: bladder preservation, trimodal therapy, muscle invasive bladder cancer (MIBC); for urethral cancer: urethra/penile-sparing, urethral carcinoma. "
4.	Drug Therapy (Chemotherapy) 08/01/2019 - "Metastatic patients were initiated chemotherapy according to the histological type of urethral cancer. " 05/01/2017 - "There is no established chemotherapy regimen in metastatic primary urethral cancer (mPUC). " 07/01/2016 - "[Combined Chemotherapy with Radiation was Tolerable and Effective Treatment in Female Octogenarian Patients with Urethral Cancer -Two Case Reports]." 01/01/1995 - "After surgical removal of the urethral neoplasm the patient was treated with combined chemotherapy (6 cycles of the CHOP scheme). " 07/01/2016 - "We report two octogenarian patients with primary urethral cancer treated with chemotherapy and external beam radiation therapy. "
5.	Chemoradiotherapy 06/01/2007 - "There are few controlled clinical trials using adjuvant or radical radiotherapy +/- chemotherapy in kidney, ureter, and urethra cancers; there are several reports of muscle-invasive bladder cancer using multimodality treatment: intravesical surgery and neo-adjuvant chemotherapy to radiotherapy or concomitant radiochemotherapy with organ preservation. "