Uncoupling Agents

Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.

Also Known As:

Networked: 21 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Shulman, Gerald I: 3 articles (01/2018 - 11/2013)
2.	Jurczak, Michael J: 2 articles (01/2017 - 11/2013)
3.	Perry, Rachel J: 2 articles (01/2017 - 11/2013)
4.	Samuel, Varman T: 1 article (01/2018)
5.	Geisler, John G: 1 article (05/2017)
6.	Halpern, Joshua: 1 article (05/2017)
7.	Marosi, Krisztina: 1 article (05/2017)
8.	Mattson, Mark P: 1 article (05/2017)
9.	Abulizi, Abudukadier: 1 article (01/2017)
10.	Aspichueta, Patricia: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 06/01/1961 - "Evaluation of some uncoupling agents in the chemotherapy of experimental cancer: a study of their distribution in tumour-bearing rats." 04/01/1962 - "IX. The effects of uncoupling agents on the oxidation of fatty acids by transplantable tumors." 06/01/1961 - "The effects of uncoupling agents on the uptake and incorporation of glycine by transplantable tumors." 04/01/1983 - "Results obtained demonstrate that (a) the apparent Km and Vmax values for adenosine diphosphate and adenosine triphosphate uptake are significantly lower in hepatoma compared to normal or regenerating liver mitochondria, (b) the Vmax values for adenosine diphosphate uptake correlate with tumor growth rate, and (c) the Km values for adenosine triphosphate in both hepatoma and normal mitochondria are lowered in the presence of added uncoupling agents; however, the extent of decrease is much less in fast-growing tumors than in slow-growing tumors and normal tissues. "
2.	Myocardial Ischemia (Ischemic Heart Diseases) 04/01/2011 - "The purpose of this study was to investigate the roles of loss of oxidative phosphorylation and activation of the mitochondrial ATP-sensitive K+ channel and permeability transition pore in VF development during myocardial ischemia by using mitochondrial uncoupling agents (carbonyl cyanide m-chlorophenylhydrazone and 2,4-dinitrophenol) and channel blockers (5-hydroxydecanoate and cyclosporine A) at concentrations that have been demonstrated to block the intended targets selectively. "
3.	Non-alcoholic Fatty Liver Disease 01/01/2018 - "Finally, a novel class of liver-targeted mitochondrial uncoupling agents increases hepatocellular energy expenditure, reversing the metabolic and hepatic complications of NAFLD." 11/05/2013 - "These results demonstrate that the beneficial effects of DNP on hypertriglyceridemia, fatty liver, and insulin resistance can be dissociated from systemic toxicities and suggest the potential utility of liver-targeted mitochondrial uncoupling agents for the treatment of hypertriglyceridemia, NAFLD, metabolic syndrome, and T2D. "
4.	Hypertriglyceridemia 01/01/2017 - "Taken together, these results provide proof of concept for the development of liver-targeted mitochondrial uncoupling agents as a potential novel therapy for lipodystrophy-associated hypertriglyceridemia, NASH and diabetes.-Abulizi, A., Perry, R. " 11/05/2013 - "These results demonstrate that the beneficial effects of DNP on hypertriglyceridemia, fatty liver, and insulin resistance can be dissociated from systemic toxicities and suggest the potential utility of liver-targeted mitochondrial uncoupling agents for the treatment of hypertriglyceridemia, NAFLD, metabolic syndrome, and T2D. "
5.	Ventricular Fibrillation 04/01/2011 - "Mitochondrial uncoupling agents trigger ventricular fibrillation in isolated rat hearts." 05/01/2003 - "Effects of heart isolation, voltage-sensitive dye, and electromechanical uncoupling agents on ventricular fibrillation."

Related Drugs and Biologics

1.	2,4-Dinitrophenol (2,4 Dinitrophenol)
2.	Adenosine Triphosphate (ATP)
3.	Cyclosporine (Ciclosporin)
4.	mesoxalonitrile
5.	Sodium Azide
6.	Ionophores
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Trichodermin
9.	Thyroid Hormones
10.	Rotenone

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics