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Unconsciousness (Loss of Consciousness)

Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental stimuli. (From Adams et al., Principles of Neurology, 6th ed, pp344-5)
Also Known As:
Loss of Consciousness; State, Unconscious; Unconscious States; Consciousness, Loss of; Unconscious State
Networked: 1731 relevant articles (25 outcomes, 106 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Headache (Headaches)
2. Pain (Aches)
3. Abdominal Pain (Pain, Abdominal)
4. Wounds and Injuries (Trauma)
5. Amnesia (Dissociative Amnesia)

Experts

1. Laureys, Steven: 17 articles (01/2021 - 01/2010)
2. Hudetz, Anthony G: 15 articles (01/2022 - 07/2006)
3. Brown, Emery N: 14 articles (01/2022 - 12/2010)
4. Devor, Marshall: 13 articles (11/2022 - 10/2001)
5. Boveroux, Pierre: 11 articles (01/2019 - 01/2010)
6. Minert, Anne: 10 articles (11/2022 - 01/2016)
7. Schneider, Gerhard: 10 articles (10/2021 - 11/2004)
8. Purdon, Patrick L: 10 articles (01/2021 - 12/2010)
9. Yu, Tian: 9 articles (07/2021 - 04/2015)
10. Mashour, George A: 9 articles (01/2021 - 11/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Unconsciousness:
1. SteroidsIBA
05/01/2012 - "Age, loss of consciousness, optic canal fracture, preoperative steroid megadose treatment, and optic nerve sheath incision were all factors that showed no significant correlation with therapeutic efficacy. "
02/01/2023 - "The relative risks for prognosticators with a statistically significant range of confidence intervals were poor initial visual acuity, greater relative afferent pupillary defect (RAPD) grades, deranged flash VEP variables (absent VEP, reduction in amplitude ratio (>50%), and increased interocular latency differences), loss of consciousness during injury, age greater than 40 years, and lack of improvement after 48 hours of steroid treatment. "
02/01/2003 - "Four variables showed a significantly increased risk for no recovery of visual acuity: presence of blood within the posterior ethmoidal cells (RR = 2.25, 95% CI 1.25 to 4.04); age over 40 years (RR = 1.79, 1.07 to 2.99); loss of consciousness associated with traumatic optic neuropathy (RR = 2.21, 1.17 to 4.16); and absence of recovery after 48 hours of steroid treatment (p < 0.01, Fisher's exact test). "
10/01/2010 - "The incidences of loss of consciousness and intracranial hemorrhage after head injury, the ratios of admission and craniotomy, the intervals between head injury and steroid treatment, the volumes of olfactory bulbs, and the incidences of subfrontal lobe damage were not significantly different between patients whose thresholds improved and those whose thresholds did not improve. "
01/01/1986 - "Soon after transplantation he developed fever and a skin rash, followed, after response to high-dose steroids, by fever, acute renal failure, jaundice, progressive loss of consciousness and death after 2 weeks of transplant. "
2. Propofol (Diprivan)FDA LinkGeneric
3. Fentanyl (Sublimaze)FDA LinkGeneric
4. Anesthetics (Anesthetic Agents)IBA
5. Oxygen (Dioxygen)IBA
6. Sevoflurane (Ultane)FDA LinkGeneric
7. Hypnotics and Sedatives (Sedatives)IBA
8. Glucose (Dextrose)FDA LinkGeneric
9. Lidocaine (Xylocaine)FDA LinkGeneric
10. Lactic Acid (Lactate)FDA LinkGeneric

Therapies and Procedures

1. Anesthesia
2. Therapeutics
3. Cardiopulmonary Resuscitation (CPR)
4. Cautery
5. Craniotomy