|5.||Wounds and Injuries (Trauma)
|1.||Konturek, S J: 33 articles (10/2011 - 05/2000)|
|2.||Brzozowski, T: 32 articles (10/2013 - 05/2000)|
|3.||Konturek, P C: 31 articles (10/2011 - 05/2000)|
|4.||Kirsner, Robert S: 27 articles (09/2015 - 08/2002)|
|5.||Chan, Francis K L: 25 articles (07/2014 - 01/2002)|
|6.||Armstrong, David G: 24 articles (05/2015 - 09/2002)|
|7.||Hawkey, C J: 23 articles (05/2008 - 02/2000)|
|8.||Lietman, Thomas M: 21 articles (06/2015 - 11/2008)|
|9.||Acharya, Nisha R: 21 articles (06/2015 - 09/2009)|
|10.||Higuchi, Kazuhide: 20 articles (12/2015 - 07/2002)|
|1.||Omeprazole (Esomeprazole)FDA LinkGeneric
01/01/1989 - "In conclusion, omeprazole 20 mg each morning was found to be safe and highly effective for treatment of gastric and prepyloric ulcer in Korean patients, producing a 98% healing rate. "
01/01/1989 - "The healing efficacy of omeprazole was assessed in 57 Korean patients with endoscopically-proven gastric (GU) and/or prepyloric (PPU) ulcers of at least 5 mm diameter. "
04/01/1999 - "Horses treated with omeprazole had significantly (P < 0.01) more improvement in ulcer scores at the end of the study compared with controls. "
11/01/2008 - "Both the extracts produced significant reduction in ulcer index (P < 0.05) in all the models and the results were comparable with that of omeprazole-treated group. "
06/01/2005 - "DG showed significant protection against CRU (68.37%), AL (88.87%), ASP (38.2%), PL (40.63%) and HST (63.15%) induced ulcer models, whereas standard drug omeprazole (OMZ) showed protection index of 83.86, 56.35, 70.31 and 84.21%, respectively in CRU, ASP, PL and HST models. "
|2.||Ranitidine (Zantac)FDA LinkGeneric
02/13/1982 - "Ranitidine appears to be a safe and highly effective treatment of gastric ulceration, with about 90% of ulcers healed after eight weeks."
12/01/2005 - "The clinical effects of the combination of Jianweiyuyang granules and ranitidine capsules were better than those of western medicine, with improvement in symptoms and syndrome (P < 0.01 to 0.05), but there was not significant difference with the rate of ulcer healing and the Hp clearance among the combination of Jianweiyuyang granules and ranitidine capsules, Jianweiyuyang granules, and ranitidine capsules (P > 0.05). "
08/01/1985 - "Nocturnal gastric acid inhibition was significantly greater in patients who responded to ranitidine than in those whose ulcer did not heal. "
06/01/1982 - "Ulcer symptoms resolved or improved in a greater proportion of patients on ranitidine, and this was associated with a significantly lower antacid consumption. "
02/01/1990 - "Other ulcer related symptoms such as fullness etc. were more rapidly relieved with ranitidine. "
|3.||Cimetidine (Biomet)FDA LinkGeneric
01/01/1978 - "In most studies Cimetidine is superior to placebo or equipotent to a high dose antacid regimen, the latter being accepted to be of beneficial effect on ulcer healing. "
07/01/1991 - "Cimetidine provided the best protection against stress-induced ulcers. "
01/01/1978 - "3. The marked sustained reduction of acid production most probably accounts for the protective effects of cimetidine against ulcer production in the rat stomach."
09/01/1978 - "Cimetidine, therefore, seems to be very effective in preventing stress induced ulcers in rat when instilled in the stomach before the stress."
01/01/1988 - "The decrease in the size of the ulcer was significantly greater in the first two weeks of cimetidine treatment than in the cimetidine-placebo group (P less than 0.05). "
|4.||Ethanol (Ethyl Alcohol)IBA
08/01/1996 - "It is highly effective against ethanol-induced ulcers. "
01/01/2014 - "africana was effective against ethanol even after the induction of ulcer, indicating that it can have protective and curative effects against gastric lesion. "
09/01/2011 - "In the model of ethanol-induced ulcers, we observed a significant reduction in all the parameters analysed; the curative ratios obtained were 49.31±0.57, 74.31±0.91 and 79.86±0.59 for the groups treated with 50 and 100mg/kg of extract of M. "
01/01/2015 - "The HEGG (50-200 mg/kg) showed a significant reduction in ulcer index in HCl/Ethanol-induced ulcer. "
11/01/2014 - "All the studied parameters indicated that the total extract of Ficus cordata at 500mg/kg possess moderate hepatoprotective effect, good protection against ethanol induced ulcer and weak nephroprotective effect. "
|5.||Sucralfate (Carafate)FDA LinkGeneric
12/01/2005 - "After the intervetion, there was a significant improvement in hand-hygiene practices (p<0.001) among healthcare providers and increased use of sucralfate (p=0.05) for stress ulcer prophylaxis. "
02/01/2001 - "The drug given orally in doses of 200 and 600 mg/kg twice daily for five days, showed significant protection against all the above experimental ulcer models and the results were comparable with those elicited by sucralfate (SF, 250 mg/kg, p.o., BD x 5 days). "
07/01/1994 - "The potential advantages of sucralfate lie in the better quality of ulcer healing associated with longer duration of remission."
06/09/1989 - "It is concluded that 1 g sucralfate twice daily is more effective than a placebo and is safe for the maintenance treatment of duodenal and pyloric ulcer disease."
01/01/1995 - "The mucosal-coating drug sucralfate has not been found effective in preventing NSAID ulcers. "
|6.||Indomethacin (Indometacin)FDA LinkGeneric
11/01/1986 - "These compounds, as well as the 7-(2-chloropropionyl) derivative 2d, also exhibited antiinflammatory activity; in addition, 2c,d were highly effective in inhibiting indomethacin-induced ulcers in the rat."
02/01/1993 - "After a 2-week treatment with indomethacin, a histological study of the ulcers showed that the length of rupturing of the muscularis mucosa was significantly greater than that observed in the control group. "
01/01/2015 - "Results indicate absence of ulcers and significantly higher and prolonged anti-inflammatory efficacy for formulations F1 and F2, with carrier: coat ratio, 5:1 and drug loads of 20 and 40 %, respectively, compared with standard oral indomethacin. "
01/01/2015 - "Animals pretreated with GC extract showed a significant reduction in ulcer score, ulcer index, gastric volume, and gastric total acidity in indomethacin-induced ulcer models in a dose dependent manner when compared to the ulcerated control group. "
11/01/2004 - "It also afforded significant protection against alcohol and indomethacin induced ulcer as well as stress induced ulceration. "
|7.||Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/01/1992 - "It is effective in preventing NSAID-induced ulcers, and does not interfere with the desired analgesic or anti-inflammatory effects of NSAIDs. "
01/01/1989 - "H2-receptor antagonists have proved effective in ulcer treatment, and their use as prophylaxis against the side effects of NSAIDs is being widely studied. "
01/01/1988 - "H2-receptor antagonists have proved effective in ulcer treatment, and their use as prophylaxis against the side-effects of NSAIDs is being widely studied. "
09/01/2008 - "To clarify this situation we have performed a systematic literature search to find randomized controlled trials comparing the efficacy of eradication in patients receiving NSAIDs to prevent ulcer development. "
09/15/2001 - "The author created a study (1989-1994) to determine the efficacy of one exposure (ulcer-healing drugs) in preventing the serious upper gastrointestinal toxicity associated with another exposure (nonsteroidal anti-inflammatory drugs (NSAIDs)). "
|8.||Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/01/2012 - "Treatment with Terminalia belerica methanolic extract further provided significant antiulcer protection against aspirin induced ulcers but not in cold stress restraint model. "
07/16/1994 - "52% of the aspirin-treated group showed significant reduction in ulcer size compared with 26% of placebo recipients (p < 0.007). "
07/01/2013 - "max was found to be effective against aspirin induced ulcers."
01/01/2008 - "There are many potential gastroprotective drugs available in Japan, and studies are needed to assess the relative effectiveness of various strategies including PPI use for the prevention of aspirin-related upper GI ulcer complications and whether any of these other agents also provide protection against small bowel or colonic damage. "
09/01/2015 - "A bespoke web-based trial management system developed for the trial (and housed within the secure NHS Data Network) communicates directly with the HEAT Toolkit software downloaded at participating practices, which issues queries searching entry criteria (≥ 60 years, on chronic aspirin ≤ 325 mg daily, not on anti-ulcer therapy or non-steroidal anti-inflammatory drugs) for GP review of eligibility. "
|9.||Misoprostol (Cytotec)FDA LinkGeneric
09/06/2004 - "Maintenance of ulcer healing is significantly greater in those who receive ongoing PPI treatment compared with placebo, and adverse events and treatment withdrawals are fewer compared with their occurrence in persons treated with misoprostol. "
01/01/1992 - "Although therapy for patients with NSAID-induced ulcers or those at high risk of developing them is still a matter of debate, the current literature supports the use of misoprostol as the only drug effective for the prevention of both NSAID-induced gastric and duodenal ulceration. "
01/08/2001 - "That the Misoprostol Ulcer Complications Outcomes Safety Assessment (MUCOSA) trial found full-dose misoprostol to be more effective in ulcer prevention than it was in prevention of ulcer complications suggests that either many of the ulcer complications were related to H. "
03/01/2000 - "PPI have now been definitively shown to be more effective in the relief of symptoms and in the healing and prevention of ulcers/erosions than H2-antagonists and also better tolerated than misoprostol. "
05/01/1990 - "Studies to date indicate that the only appropriate therapy to prevent NSAID ulcers is misoprostol, and that this drug is also effective in healing such ulcers while NSAID treatment is continued. "
|10.||Proton Pumps (Proton Pump)IBA
01/01/1992 - "The proton pump inhibitor (PPI), significantly more potent and long-acting than H2-blocker, is expected to be more effective for postoperative recurrent ulcers. "
11/21/2014 - "Two-wk treatment with a proton pump inhibitor is as effective as four-week treatment for healing post ESD ulcers."
01/01/2013 - "Several trials have shown the efficacy of 4 or 8 weeks of proton pump inhibitor (PPI) administration for post-ESD ulcers. "
03/01/2010 - "Several trials have shown the efficacy of 4 or 8 weeks of proton pump inhibitor (PPI) administration for post-ESD ulcers. "
02/01/2012 - "Optimal duration of proton pump inhibitor in the treatment of endoscopic submucosal dissection-induced ulcers: a retrospective analysis and prospective validation study."
03/01/2011 - "The study group showed a significant reduction in the median time needed to heal ulcers, reduction of the number of admissions and amputation frequency."
01/01/2005 - "Pooled data from five trials on diabetic ulcers (118 patients) suggested a significant reduction in the risk of major amputation with HBOT (RR: 0.31; c.i. 0.13 to 0.71) with a NNT of 4 (c.i. 3 to 11). "
01/01/2015 - "Moreover, significant improvement in the amputation rate, ulcer healing, and ABI were also found based on the time point and stem cell source. "
01/01/2015 - "After synthesizing data, the meta-analysis showed significant improvement in the amputation rate (OR=0.33, 95%CI=0.22-0.51; P<0.001), ulcer healing (OR=6.11, 95%CI=3.04-12.28; P<0.001), and ABI (SMD=0.65, 95%CI=0.33-0.97; P<0.001) for the stem cell-based therapy group compared with the controls. "
01/01/2015 - "Improvement in walking distance as reported by the patient, measured claudication distance, ulcer healing, major amputation-free survival and delayed complications (> 72 hours) were not reported in either of the studies. "
10/01/2013 - "All patients achieved complete debridement of the necrotic area and a significant reduction of the total ulcer area by day 20, while other parameters improved significantly over time. "
12/01/2003 - "The latter two procedures may be beneficial in the treatment of nonhealing ulceration in horses, but the results of this study suggest that these procedures should only be performed following failure of the ulcer to heal after epithelial debridement."
10/01/2012 - "These two cases suggest that wide excision, thorough debridement and coverage with vascularised tissue are effective in treating radiation ulcers and emphasise that all radiation sources and their management should be strictly controlled."
02/01/2009 - "We reduced the dose of immunosuppressive drug and performed debridement of the ulcer, which responded well to treatment. "
05/01/2006 - "On minimal improvement in the epithelial defect in 1 week, surgical debridement of the ulcer base was performed. "
04/01/2000 - "Postoperative angiography showed satisfactory graft patency and distal run-off, and the ulcer improved. "
01/01/2011 - "autologous skin cell grafts are feasible, well tolerated, and apparently effective in the treatment of diabetic ulcers of the lower limbs in advanced age. "
06/01/2002 - "Pinch grafts are very useful for arterial ulcers. "
01/01/2013 - "In this study, we have evaluated the safety and efficacy of the combination of autologous platelet gel (PG) and skin graft for treating large size recalcitrant ulcers. "
04/01/2015 - "Feasibility and efficacy of endoscopic bio-sheet graft therapy for the management of artificial ulcers and the evaluation of healing conditions based on histology changes in the remaining gastric bed tissues harvested from the stomachs. "
01/01/1988 - "Thus basal and stimulated acid output is normal in most ulcer patients, and this is also so for gastric and duodenal pH. Gastric acid secretion does not separate patients with rapid recurrence after medical treatment from those with a long period of remission, and acid secretion is usually not higher in patients with recurrence after vagotomy than in patients without relapse. "
12/01/1990 - "It was established that intraoperative pH measurement, carried out by an improved procedure, provided for objective control over complete and adequate vagotomy, made it possible to predict the risk of ulcer recurrence in the postoperative period and, in accordance with that, to choose the methods for its prevention."
06/01/2014 - "For patients with perforated ulcers, vagotomy/drainage produced similar outcomes as local procedures but required a significantly greater length of postoperative hospitalization. "
01/01/2008 - "Vagotomy at the patients with ulcers after primary resections demonstrates good results. "
01/01/2000 - "This method of vagotomy was used in 46 patients with ulcer disease of the duodenum and gave good results. "
01/01/2014 - "As compared with the baseline, circulating endothelial progenitor cell level (as shown by flow cytometry) was significantly increased (p<0.003), whereas the CLI-related ulcers and painfulness were significantly improved (all p<0.01) by day 90 after treatment. "
01/01/2010 - "(iii) When the ulcer score estimated after treatment was compared with that before the start of treatment, a significant improvement of the score was noted. "
04/01/2002 - "The result indicated a significant reduction in the ulcer lesion count, volume of gastric juice and acidity and increase in pH and hexosamine after treatment with extract. "
05/12/1979 - "Though a small, consistent improvement occurred with placebo, there was a significant reduction in mean pair scores and numbers of new ulcers recorded daily during the active-treatment periods, the effect lasting for at least four weeks after treatment was stopped. "
01/01/2012 - "Carried out in the dynamics fibrogastroduodenoscopy after treatment showed that 100% of the observed total endoscopic remission which is manifested in the disappearance of opalescent gray overlay on the bottom of the ulcer and ulcer epithelization."