|1.||Guillemette, Chantal: 7 articles (02/2015 - 05/2002)|
|2.||Lazarus, Philip: 7 articles (12/2012 - 08/2003)|
|3.||Mackenzie, Peter I: 6 articles (06/2015 - 03/2004)|
|4.||Hu, Dong Gui: 5 articles (06/2015 - 08/2009)|
|5.||Huang, Ching-Shan: 5 articles (08/2014 - 08/2005)|
|6.||Yamamoto, Wataru: 5 articles (01/2012 - 02/2006)|
|7.||Sasaki, Yasutsuna: 5 articles (01/2012 - 02/2006)|
|8.||Araki, Kazuhiro: 5 articles (01/2012 - 02/2006)|
|9.||Fujita, Ken-ichi: 5 articles (01/2012 - 02/2006)|
|10.||Nagashima, Fumio: 5 articles (01/2012 - 02/2006)|
12/01/2012 - "Identification and functional characterization of a novel UDP-glucuronosyltransferase 2A1 splice variant: potential importance in tobacco-related cancer susceptibility."
06/01/2008 - "Comparison of expression profiles in androgen dependent and independent prostate tumors demonstrated a marked increase of the expression of UDP-glucuronosyltransferase 2B15 (UGT2B15), an androgen catabolic enzyme. "
02/01/2006 - "We sequenced from 5'-franking region to intron 1 (to 337 bp downstream from exon 1) of the UDP-glucuronosyltransferase (UGT) 1A9 gene prepared from 55 Japanese cancer patients. "
02/01/2006 - "We sequenced exon 1 of the UDP-glucuronosyltransferase (UGT) 1A7 gene from 52 Japanese cancer patients. "
04/01/2005 - "Nineteen genetic variations, including 11 novel ones, were found in exon 1 and its flanking region of the UDP-glucuronosyltransferase (UGT) 1A4 gene from 256 Japanese subjects, consisting of 60 healthy volunteers, 88 cancer patients and 108 arrhythmic patients. "
01/01/1996 - "In an attempt to confirm the efficacy of D3 as an antineoplastic agent, the present investigation aims at characterizing the importance of D3 in modulating hepatic drug metabolizing enzymes, namely, cytosolic glutathione S-transferase (GSHT), microsomal UDP glucuronyl transferase (UDPGT), and cytochrome P-450, which have been reported by us in recent literature as significant neoplastic markers in mice bearing Dalton's lymphoma (DL). "
01/01/1993 - "The potentiating effect of vanadium was supported by biochemical analysis of autopsies relating to markers like microsomal cytochrome P-450, UDP glucuronyl transferase (UDPGT) and cytosolic glutathione-S-transferase (GSHT) in the hepatic tissue of the hosts, which showed substantial alterations in the extent of tumor regression as compared to their lymphoma and normal counterparts, prolonging the survival of the hosts."
02/01/2015 - "Japanese clinical practice guidelines indicate that some clinical biomarkers, such as epidermal growth factor receptor gene mutations, echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion gene and uridine diphosphate glucuronosyltransferase genotypes should be determined in appropriate lung cancer patients. "
01/01/2015 - "The uridine diphosphate glucuronosyltransferase (UGT) gene 1A1*6 polymorphism, which affects irinotecan metabolism, has been associated with improved survival in lymphoma patients treated with of carboplatin, dexamethasone, etoposide and irinotecan (CDE-11). "
|3.||Sickle Cell Anemia (Hemoglobin S Disease)
02/01/1978 - "Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia."
03/01/2008 - "The purpose of the study was to determine if UDP-glucuronosyltransferase (UGT) 2B7 allelic variants encoding for UGT2B7, primary enzyme responsible for morphine glucuronidation contribute to the variability in the hepatic clearance of morphine in sickle cell disease (SCD). "
02/01/1978 - "To determine the effects of this excessive bilirubin load on the microsomal conjugating enzyme, hepatic bilirubin UDP-glucuronyltransferase, levels of this enzyme were measured in liver biopsies from patients with sickle cell anemia and several comparison groups. "
08/01/2003 - "UDP-glucuronosyltransferase 1 gene promoter polymorphism is associated with increased serum bilirubin levels and cholecystectomy in patients with sickle cell anemia."
02/01/1978 - "UDP-glucuronyltransferase activity in 14 patients with sickle cell anemia was 2-fold greater (P less than 0.005) than in 14 nonjaundiced comparison patients without liver disease. "
|4.||Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/01/2015 - "To analyze the distribution of uridine diphosphate glucuronosyltransferase (UGT)1A1 gene polymorphisms in Chinese patients with extensive-stage small-cell lung cancer (E-SCLC), and to evaluate correlations between the UGT1A1 gene polymorphisms and toxicity, and efficacy of irinotecan (CPT-11) based regimen in the patients with E-SCLC. "
11/01/2015 - "This study evaluated the efficacy and safety of irinotecan/cisplatin (IP) and etoposide/cisplatin (EP) in extensive-stage small cell lung cancer (ES-SCLC) and the distribution of uridine diphosphate glucuronosyltransferase (UGT1A1). "
08/01/2007 - "Frequency of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms in neonates with prolonged and pathological jaundice in the Denizli region of Turkey."
04/08/1985 - "Congenital jaundice in rats due to the absence of hepatic bilirubin UDP-glucuronyltransferase enzyme protein."
12/15/1983 - "The congenic inbred rats should provide a stable and reproducible genetic model for studying defective UDP-glucuronosyltransferase specified by the jaundice (jj) locus."
12/15/1983 - "Differences in UDP-glucuronosyltransferase activities in congenic inbred rats homozygous and heterozygous for the jaundice locus."
07/01/1981 - "The inhibiting agent of UDP-glucuronyl transferase (UDPGT), inhibition of which is associated with breast milk jaundice syndrome in infants, was thought to be 3(alpha),20(beta)-pregnandiol. "
|1.||Uridine Diphosphate (UDP)
|4.||Cytochrome P-450 Enzyme System (Cytochrome P450)
|5.||Glutathione Transferase (Glutathione S-Transferase)
|8.||Morphine (MS Contin)
|10.||Etoposide (VP 16)
|1.||Combination Drug Therapy (Combination Chemotherapy)
|2.||Drug Therapy (Chemotherapy)
|3.||Transplantation (Transplant Recipients)