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Tyrothricin

A polypeptide antibiotic mixture obtained from Bacillus brevis. It consists of a mixture of three tyrocidines (60%) and several gramicidins (20%) and is very toxic to blood, liver, kidneys, meninges, and the olfactory apparatus. It is used topically.
Also Known As:
Codétricine; Dermotricine; Hydrotricine; Martricin; Tyroderm; Tyrosur
Networked: 69 relevant articles (5 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Rautenbach, Marina: 2 articles (06/2022 - 06/2007)
2. Leussa, Adrienne N-N: 1 article (06/2022)
3. Adegoke, O: 1 article (10/2020)
4. Atkinson, R: 1 article (10/2020)
5. Evangelista, C: 1 article (10/2020)
6. Maillard, J-Y: 1 article (10/2020)
7. Shepard, A: 1 article (10/2020)
8. Wesgate, R: 1 article (10/2020)
9. Bell, John: 1 article (12/2019)
10. Burgoyne, Douglas S: 1 article (12/2019)

Related Diseases

1. Wounds and Injuries (Trauma)
2. Pharyngitis (Sore Throat)
06/01/2016 - "In daily practice, the application of tyrothricin containing formulations is relatively limited: It is used in sore throat medications and in agents for the healing of infected superficial and small-area wounds. "
12/01/2018 - "The aim of this multi-centre, randomised, double-blind, placebo-controlled trial was to compare the efficacy and safety of the fixed combination of 0.5 mg tyrothricin, 1.0 mg benzalkonium chloride, and 1.5 mg benzocaine (study drug marketed as Dorithricin® ) in repeat dosing for 3 days to match placebo lozenges in the treatment of acute pharyngitis in adults. "
12/01/2018 - "Local treatment with the fixed combination (0.5 mg tyrothricin, 1.0 mg benzalkonium chloride, and 1.5 mg benzocaine) provides a rapid analgesic effect and is effective in relieving both severe throat pain as well as difficulty in swallowing associated with acute pharyngitis leading to a 64% improved complete remission within 72 hours. "
10/01/2020 - "The aims of this study were to explore the development of bacterial resistance and cross-resistance in four common human pathogens following realistic exposure to antibiotics found in over-the-counter (OTC) sore throat medicines: gramicidin, neomycin, bacitracin and tyrothricin. "
12/01/2019 - "Eligible studies included those in patients with sore throat of any aetiology receiving the topical (local) antibiotics tyrothricin, bacitracin, gramicidin or neomycin where the antibiotic was topically/locally applied via the nasal cavity or throat. "
3. Seborrheic Dermatitis
4. Pain (Aches)
5. Mycoses (Diseases, Fungus)

Related Drugs and Biologics

1. Benzocaine (Americaine)
2. Benzalkonium Compounds (Benzalkonium Chloride)
3. Chitosan
4. Propylene Glycol (1,2 Propanediol)
5. Peptides (Polypeptides)
6. Fatty Acids (Saturated Fatty Acids)
7. Analgesics (Analgesic Drugs)
8. benzocaine drug combination benzalkonium chloride tyrothricin
9. Neomycin
10. Bacitracin (Baci-Rx)

Related Therapies and Procedures

1. Therapeutics
2. Intravenous Administration
3. Root Planing