Tyrosine Decarboxylase

A pyridoxal-phosphate protein that catalyzes the conversion of L-tyrosine to tyramine and carbon dioxide. The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine. (From Enzyme Nomenclature, 1992) EC 4.1.1.25.

Also Known As:

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	D'Andrea, Giovanni: 2 articles (01/2015 - 01/2010)
2.	Li, Chao: 1 article (05/2022)
3.	Liu, Xiaomin: 1 article (05/2022)
4.	Ma, Fengwang: 1 article (05/2022)
5.	Wang, Yanpeng: 1 article (05/2022)
6.	Yuan, Xiao: 1 article (05/2022)
7.	Zhang, Zhijun: 1 article (05/2022)
8.	Castejon, Maria: 1 article (01/2019)
9.	El Aidy, Sahar: 1 article (01/2019)
10.	El-Gendy, Ahmed O: 1 article (01/2019)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 11/29/2022 - "Association Between Microbial Tyrosine Decarboxylase Gene and Levodopa Responsiveness in Patients With Parkinson Disease." 01/01/2019 - "Our results highlight the role of microbial metabolism in drug availability, and specifically, that abundance of bacterial tyrosine decarboxylase in the proximal small intestine can explain the increased dosage regimen of levodopa treatment in Parkinson's disease patients." 01/01/2019 - "In situ levels of levodopa are compromised by high abundance of gut bacterial tyrosine decarboxylase in patients with Parkinson's disease. " 08/01/2023 - "Piperine improves levodopa availability in the 6-OHDA-lesioned rat model of Parkinson's disease by suppressing gut bacterial tyrosine decarboxylase." 01/29/2010 - "These findings raise the possibility that Parkinson's disease is firstly characterized by abnormalities of tyrosine decarboxylase, rather than tyrosine hydroxylase, enzyme activity. "
2.	Wounds and Injuries (Trauma) 08/01/2005 - "Elevated tyrosine decarboxylase and tyramine hydroxycinnamoyltransferase levels increase wound-induced tyramine-derived hydroxycinnamic acid amide accumulation in transgenic tobacco leaves." 02/01/2005 - "The wound-activated biosynthesis of phytoalexin hydroxycinnamic acid amides of tyramine was compared in untransformed and transgenic tobacco (Nicotiana tabacum) lines that express tryptophan decarboxylase (TDC), tyrosine decarboxylase (TYDC), or both activities. " 02/01/2005 - "Wound-inducible biosynthesis of phytoalexin hydroxycinnamic acid amides of tyramine in tryptophan and tyrosine decarboxylase transgenic tobacco lines."
3.	Mycoses (Diseases, Fungus) 01/25/1993 - "A group of recently isolated parsley (Petroselinum crispum) cDNAs representing genes that are transcriptionally activated upon fungal infection or elicitor treatment have been demonstrated to encode tyrosine decarboxylase (TyrDC). "
4.	Migraine Disorders (Migraine) 01/01/2015 - "This finding prompts to go over COMT to explain catecholamine derangement in migraine, exploring enzymes involved in catecholamines synthesis and catabolism, such as monoamine-oxidase, dopamine beta-hydroxylase, tyrosine-hydroxylase or tyrosine-decarboxylase, among others."
5.	Infections 05/01/2022 - "Tyrosine decarboxylase (TYDC) is not only involved in the synthesis of dopamine in plants but may also play an important role in the resistance of plants to pathogen infection. "

Related Drugs and Biologics

1.	Levodopa (L Dopa)
2.	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
3.	Tyramine
4.	Enzymes
5.	Coumaric Acids
6.	Amides
7.	Perforin
8.	Virulence Factors (Pathogenicity Factors)
9.	Gelatinases
10.	Vancomycin