Tunicamycin

An N-acetylglycosamine containing antiviral antibiotic obtained from Streptomyces lysosuperificus. It is also active against some bacteria and fungi, because it inhibits the glucosylation of proteins. Tunicamycin is used as tool in the study of microbial biosynthetic mechanisms.

Networked: 690 relevant articles (27 outcomes, 78 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hara, Hideaki: 10 articles (01/2015 - 10/2006)
2.	Shimazawa, Masamitsu: 10 articles (01/2015 - 10/2006)
3.	Zhou, Bo: 9 articles (11/2017 - 06/2013)
4.	Li, Huixia: 7 articles (11/2017 - 06/2013)
5.	Xu, Lin: 7 articles (11/2017 - 06/2013)
6.	Jiang, Chen Chen: 7 articles (01/2015 - 06/2007)
7.	Zhang, Xu Dong: 7 articles (01/2015 - 06/2007)
8.	Banerjee, Dipak K: 6 articles (01/2022 - 08/2011)
9.	Liu, Jiali: 6 articles (07/2020 - 06/2013)
10.	Sun, Hongzhi: 6 articles (11/2017 - 06/2013)

Related Diseases

1.	Neuroblastoma 07/01/2006 - "Several chemically synthesized compounds were examined for protective effects against the cell damage in tunicamycin-treated human neuroblastoma IMR-32 cells. " 01/01/2021 - "In vitro study, tunicamycin impaired the viability of VSC4.1 cells (motoneuron-neuroblastoma hybrid cell line) and increased SOCE activity, the effects of which could be abolished by 2-APB. " 02/15/2014 - "Inhibition of PKR protects against tunicamycin-induced apoptosis in neuroblastoma cells." 01/01/2014 - "Neuroblastoma N2A cells were infected with adenovirus expressing myc-tagged DHCR24 (Ad-DHCR24) or lacZ (Ad-lacZ, serving as a control) and subjected to ER-stress, induced with Tunicamycin (TM). " 07/09/2013 - "Interestingly, PADI4 was up-regulated by various stresses such as H2O2, acrylamide, and tunicamycin in neuroblastoma SK-N-SH cells but inhibited by RG. "
2.	Neoplasms (Cancer) 01/01/2018 - "Based on the quantitative and high-throughput ability, we conducted pharmacodynamics study of drug (tunicamycin) on cancer cells. " 09/15/2017 - "Studies suggest that tunicamycin may work as a therapeutic drug to cancer cells by inducing stress in the endoplasmic reticulum (ER) through unfolded protein response (UPR) and thereby promoting apoptosis. " 08/01/2015 - "In this study, we showed via the MTT assay that tunicamycin significantly decreased the viability of cancer cell lines that were co-treated with a chemotherapeutic drug. " 09/01/2014 - "The aim of the present study was to investigate whether tunicamycin (TM) induces autophagy, as well as whether the inhibition of autophagy enhances the apoptosis ofbreast cancer cells induced by TM. " 12/01/2022 - "Importantly, attenuation of the glycosylation using tunicamycin abrogated the effect of ALG8 gene on cancer stemness. "
3.	Melanoma (Melanoma, Malignant) 11/15/1984 - "In cultured melanotic melanoma, a marked decrease of pigmentation has been found to be induced by the addition of tunicamycin [Y. " 09/01/2015 - "Here we investigated gene expression profiles under ER stress in melanoma cells and found that IDH1 was dramatically increased with ER stress induced by tunicamycin. " 01/01/2013 - "Here we report that activation of the UPR response by tunicamycin (TM), an ER stress inducer, leads to accumulation of p27 and G1 cell cycle arrest in melanoma cells. " 07/01/2011 - "To establish a model of ER stress-induced apoptosis with tunicamycin and to examine whether Bim is dysregulated and its potential role in resistance of melanoma cells to apoptosis under endoplasmic reticulum (ER) stress. " 02/01/1997 - "Phages were further selected for reactivities with tunicamycin-treated melanoma cells. "
4.	Inflammation (Inflammations) 01/01/2019 - "Recombinant CCL21 improved pTr and pLE cell proliferation through activation of the PI3K and MAPK pathways and suppression of tunicamycin-induced endoplasmic reticulum (ER) stress or LPS-induced inflammation. " 07/03/2023 - "The ER stress agonist tunicamycin suppressed cell viability as well as induced ER stress, oxidative stress and inflammation. " 01/25/2023 - "The effect of CK on inflammation, pyroptosis, and ERS was blocked by the ERS inducer tunicamycin. " 08/01/2022 - "Tunicamycin led to partial abolition of the protective function of PINO against inflammation, oxidative stress and apoptosis in LPS-challenged HK-2 cells. " 01/18/2022 - "We also find that, in response to tunicamycin-induced ER stress, miR-16-5p suppression decreases apoptosis, inflammation and cardiac damage via activating the ATF6-mediated cytoprotective pathway. "
5.	Insulin Resistance 07/13/2020 - "This study proves recombinant CaMKIV inhibits tunicamycin-induced ER stress and insulin resistance by regulating autophagy. " 01/01/2020 - "Although ULK1 and ATG13 are necessary for autophagy induction after tunicamycin-induced ER stress, autophagy does not seem to directly affect tunicamycin-induced cell death, ER stress, or insulin resistance. " 01/01/2020 - "Notably, ATG13 and ULK1 deficiency ameliorated tunicamycin-induced insulin resistance, with enhanced RPS6KB1 and AKT1 phosphorylation in KO cells compared to WT cells. " 01/01/2017 - "In in vitro experiments, insulin resistance was induced by applying tunicamycin to HUVECs. " 04/01/2019 - "In our study, 3T3-L1 adipocytes were pre-treated with ERS inhibitors tauroursodeoxycholic acid (TUDCA), Ex-4 and an ERS inducer tunicamycin (TM) then induced insulin resistance. "

Related Drugs and Biologics

1.	Thapsigargin
2.	Endoplasmic Reticulum Chaperone BiP
3.	ursodoxicoltaurine
4.	Caspase 3 (Caspase-3)
5.	Adiponectin
6.	Glucosamine (Dona)
7.	salubrinal
8.	Glutamic Acid (Glutamate)
9.	Threonine (L-Threonine)
10.	Serine (L-Serine)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Immunotherapy
4.	Aftercare (After-Treatment)
5.	Intraperitoneal Injections