Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Also Known As:
Tumor Necrosis Factor; TNF-alpha; Cachectin-Tumor Necrosis Factor; TNF Superfamily, Member 2; TNFalpha; Cachectin Tumor Necrosis Factor; Tumor Necrosis Factor alpha; Cachectin; Tumor Necrosis Factor Ligand Superfamily Member 2