Tularemia

10/01/2002 - "Although an improved vaccine against tularemia is highly desirable, attempts to devise such a vaccine have been limited by the inability to construct defined allelic replacement mutants and by the lack of information on the mechanisms of virulence of F. "
01/01/2012 - "The tularemia vaccine, Francisella tularensis live vaccine strain (LVS), does not elicit complete protection against lethal challenge with a virulent type A Francisella strain. "
01/01/2018 - "We compare the virulence and efficacy of these vaccine candidates with that of LVS and discuss factors that can significantly impact the development and evaluation of live attenuated tularemia vaccines. "
01/01/2016 - "Thus, development of a successful vaccine against tularemia will require an understanding of the impact gender has on vaccine-induced protection against this organism. "
01/01/2021 - "A greater understanding of LVS attenuation may reveal new mechanisms of pathogenesis and inform strategies toward the development of an improved vaccine against tularemia."

09/01/2013 - "These data demonstrate that treatment with anti-HMGB1 antibody is beneficial in enhancing the effectiveness of current antibiotics in treating tularemia. "
03/01/1992 - "Efficacy of antibiotics in the treatment of experimental tularemia was studied comparatively on various biological models. "
04/01/2009 - "tularensis in studies of tularemia biology, especially where the use of multi-copy plasmids or antibiotic markers may not be suitable."
08/01/1967 - "[Study of the mechanism of action of antibiotics on the development of immunity in experimental tularemia]."
02/01/1962 - "[Studies on the sensitivity of some types of tularemia pathogen and Pasteurella to antibiotics in vitro]."

01/01/2014 - "Thus, liposomal ciprofloxacin is a promising treatment for tularemia and further research with the aim of enabling licensure under the animal rule is warranted. "
01/01/2001 - "The efficacy of ciprofloxacin treatment of tularemia in children is also discussed."
11/01/2022 - "Seven individuals associated with the aspiration event were screened for tularemia and treated with prophylactic ciprofloxacin. "
10/01/2022 - "An oropharyngeal form of tularemia was diagnosed and oral ciprofloxacin (2 x 750 mg) was given for three weeks by starting at the 14th gestational week. "
07/01/2019 - "A diagnosis of tularemia was made serologically, but treatment with ciprofloxacin initially failed. "

07/01/2011 - "The results of our study suggest that streptomycin is an effective choice of first-line treatment for pediatric oropharyngeal tularemia patients."
09/01/1971 - "[Study of the immunizing effect of the virulent Tularemia strain treated by streptomycin]."
12/30/1949 - "Study of three cases of tularemia observed in the Paris region; rabbit transmission; isolation of a human strain; treatment with streptomycin."
07/01/1994 - "Because of the recent lack of availability of streptomycin--currently considered the drug of choice for the treatment of tularemia--we reviewed the literature on alternative drugs that have been used for this purpose. "
07/01/1994 - "Streptomycin and alternative agents for the treatment of tularemia: review of the literature."

04/20/2007 - "The T lymphocyte antigens, which may have a role in protection against tularemia, were predicted by immunoinformatics analysis of Francisella tularensis Schu4. "
09/01/2011 - "PHR was the most effective study method that allowed to detect tularemia antigen in the environmental objects in high quantities (up to 9.2% of positive samples) and high titers (up to 1:1600). "
10/01/2006 - "Tularemia antigen was annually detected in the study samples. "
06/01/1991 - "tularemia antigen-stimulated PBMC increased 2 weeks after tularemia onset, but the mean number of CD8+ DR+ T lymphocytes did not vary during the study period and no correlation could be found between the soluble CD8 and number of CD8+ DR+ T lymphocytes. "
03/01/1981 - "The serologic study of 908 specimens of avian excrements collected during the period from autumn to spring (1977-1978) revealed that tularemia antigen could be constantly detected, starting from October. "

10/01/2014 - "This is the first report of a defined live attenuated vaccine that demonstrates efficacy against pulmonary tularemia in a NHP, and indicates that the low human virulence F. "
10/01/2002 - "An unlicensed live attenuated vaccine is available, which does appear to offer protection against ulceroglandular and pneumonic tularemia. "
02/12/2013 - "A mutant lacking this modification may be used as a live attenuated vaccine against tularemia."
01/01/2013 - "Identification of a live attenuated vaccine candidate for tularemia prophylaxis."
09/18/2009 - "novicida mutant (DeltaiglB) as a live attenuated vaccine against pneumonic tularemia. "

01/01/2017 - "Fluoroquinolone (FQ) resistance is a major health concern in the treatment of tularemia. "
05/01/2006 - "Fluoroquinolones may therefore be considered useful candidates for the treatment of pneumonic tularemia."
10/01/1999 - "Treatment of tularemia with fluoroquinolones: two cases and review."
01/01/2007 - "Comparative in vitro and in vivo efficacy of new fluoroquinolones with respect to pathogens of tularemia, glanders, melioidosis and anthrax was estimated. "
05/01/2013 - "In addition, all isolates except 1 had a minimal inhibitory concentration (MIC) for erythromycin of > 256 μg/ml. Since the fluoroquinolones showed the lowest MIC values and have advantages such as excellent bioavailability and activity, availability of oral formulations, and lower toxicities, they represent candidate therapeutic options in the first-line treatment of tularemia. "

05/01/2023 - "Moxifloxacin (56.25%) was used most frequently in the treatment of tularemia, and surgical drainage was performed for 31% of the patients. "
07/01/2016 - "In a mouse model of lethal pneumonic tularemia, MSNs loaded with moxifloxacin prevent weight loss, illness, and death, markedly reduce the burden of F. "
11/24/2015 - "Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia."
01/01/2019 - "Nanoparticle Formulation of Moxifloxacin and Intramuscular Route of Delivery Improve Antibiotic Pharmacokinetics and Treatment of Pneumonic Tularemia in a Mouse Model."
01/01/2019 - "We compared the efficacy of moxifloxacin formulated as free drug vs disulfide snap-top mesoporous silica nanoparticles (MSNs) in a mouse model of pneumonic tularemia. "

09/16/2011 - "tularensis; however, the findings demonstrate proof of principle that an immune response generated against a component of a subunit vaccine is protective against lethal respiratory and intradermal tularemia."
01/01/2018 - "An Improved Tobacco Mosaic Virus (TMV)-Conjugated Multiantigen Subunit Vaccine Against Respiratory Tularemia."
09/01/2008 - "tularensis LPS and other subunit vaccines against tularemia, but there is still a need to test its efficacy against virulent type A and type B F. "
01/01/2015 - "In this study, we used a novel approach for development of a multivalent subunit vaccine against tularemia by using an efficient tobacco mosaic virus (TMV) based delivery platform. "
01/01/2018 - "Our data highlights the potential of this biosynthetic approach for the creation of next-generation tularemia subunit vaccines."

08/01/1972 - "Tularemia treated successfully with gentamicin."
01/01/1980 - "Gentamicin was bactericidal for Francisella tularensis in vitro, was effective in mouse tularemia when given in large doses, and was effective in humans when given in the standard recommended dose."
09/02/2022 - "Gentamicin was administered on the clinical suspicion of ulceroglandular tularemia. "
01/01/2022 - "The patient received 4 weeks of gentamicin for culture-confirmed ulceroglandular tularemia. "
05/05/2021 - "Suspecting tularemia, parenteral gentamycin was added. "

01/01/2015 - "Furthermore, tularemia is not a disease extensively studied in the medical educational system in Iran, and empirical therapy may be effective in many cases. "
01/01/2018 - "This study summarizes critical parameters and endpoints of a well-characterized cynomolgus macaque model of pneumonic tularemia and demonstrates this model is appropriate for qualification, and for testing efficacy of tularemia therapeutics under Animal Rule."
02/28/2009 - "We describe the epidemiological and clinical characteristics and the efficacy of a delayed initiation to therapy in an oropharyngeal tularemia outbreak in Duzce, Turkey. "
01/01/2022 - "Structure determination of membrane localized mature FopA is essential to understand its role in pathogenesis and develop anti-tularemia therapeutics. "
01/01/2020 - "This work paves the road to developing targeted therapeutics against tularemia and aides in our understanding of the disease mechanisms of tularemia."

04/01/2012 - "Superselective neck dissection is a safe and effective option in the treatment of long lasting cervical tularemia unless it responds to medical treatment."

02/06/2015 - "Collectively, this use of orthogonal proteomic approaches reduced the complexity of potential immunogens in MPF by 96% and allowed for prioritization of target immunogens for antibody-based immunotherapies against tularemia. "
11/15/2013 - "This manuscript will review advances made and challenges in the field of immunotherapy against tularemia. "
11/15/2013 - "Immunotherapy for tularemia."
11/15/2013 - "tularensis acquiring resistance to antibiotics via natural or illicit means, augmentation of host immunity, and humoral immunotherapy have been investigated as countermeasures against tularemia. "
10/15/2007 - "These anti-Francisella hybridoma antibodies could be converted to chimeric versions with mouse V regions and human C regions to serve as components of a recombinant polyclonal antibody for clinical testing as immunotherapy of tularemia. "

03/01/1994 - "Approximately 8 years after treatment for tularemia, 14 of 22 (63.6%) individuals tested still had a positive microagglutination test for Francisella tularensis antibodies. "
07/01/1978 - "[Antibiotic treatment of experimental tularemia in mice with special reference to strong immunity established after treatment(author's transl)]."

01/01/2008 - "The treatment of tularemia in irradiated mice twith Riphampicin (daily peroral administration, 5 mg/mouse, duration of treatment--7 days) administered in 4 hours after infection was effective and caused high survival of affected mice. "
07/01/2011 - "A first-line therapy for treating tularemia is aminoglycosides (streptomycin or, more commonly, gentamicin), and treatment duration is typically 7 to 10 days, with longer courses for more severe cases. "