Pulmonary Tuberculosis

MYCOBACTERIUM infections of the lung.

Also Known As:

Tuberculosis, Pulmonary; Pulmonary Tuberculoses; Tuberculoses, Pulmonary; Consumption, Pulmonary; Consumptions, Pulmonary; Phthises, Pulmonary; Phthisis, Pulmonary; Pulmonary Consumptions; Pulmonary Phthises; Pulmonary Consumption; Pulmonary Phthisis

Networked: 12774 relevant articles (369 outcomes, 1292 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Tuberculosis (Tuberculoses)
2.	Infections
3.	Body Weight (Weight, Body)
4.	Meningeal Tuberculosis (Tuberculous Meningitis)
5.	Pneumonia (Pneumonitis)

Experts

1.	Babu, Subash: 37 articles (01/2022 - 12/2012)
2.	Selvaraj, P: 33 articles (09/2018 - 05/2000)
3.	Diacon, Andreas H: 30 articles (01/2022 - 06/2009)
4.	Narayanan, P R: 30 articles (07/2009 - 05/2000)
5.	Hernández-Pando, Rogelio: 24 articles (02/2022 - 01/2005)
6.	Li, Ji-Cheng: 24 articles (01/2022 - 06/2010)
7.	Banurekha, Vaithilingam V: 23 articles (11/2021 - 01/2013)
8.	Urazova, O I: 23 articles (11/2019 - 01/2005)
9.	Johnson, John L: 22 articles (01/2022 - 07/2002)
10.	Moideen, Kadar: 22 articles (01/2022 - 09/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pulmonary Tuberculosis:

1.	Isoniazid (Ftivazide)FDA LinkGeneric 11/01/2022 - "Correction to: Treatment With a Three-Drug Regimen for Pulmonary Tuberculosis Based on Rapid Molecular Detection of Isoniazid Resistance: A Noninferiority Randomized Trial (FAST-TB)." 08/01/2022 - "Treatment With a Three-Drug Regimen for Pulmonary Tuberculosis Based on Rapid Molecular Detection of Isoniazid Resistance: A Noninferiority Randomized Trial (FAST-TB)." 07/12/2018 - "Objective: To study the relationship between the weight change trend of initial treatment patients with pulmonary tuberculosis and the dose change trend of isoniazid, and therefore to analyze the appropriate dose of isoniazid. " 07/01/2011 - "This study was designed to characterize the population pharmacokinetics of isoniazid in South African pulmonary tuberculosis patients. " 11/15/2004 - "In these studies, the EBA of isoniazid during the first 2 days of treatment was determined for 97 patients with sputum smear-positive pulmonary tuberculosis following isoniazid doses of < or =37.5 mg, 75 mg, 150 mg, 300 mg, and 600 mg. The NAT2 genotype was determined in 70 patients, and the association between EBA and genotype was examined in this subgroup. "
2.	Rifampin (Rifampicin)FDA LinkGeneric 05/04/1974 - "Therapeutic efficacy of rifampin in newly detected pulmonary tuberculosis." 06/01/2021 - "Efficacy of the Xpert Mycobacterium tuberculosis/rifampicin assay for diagnosing sputum-smear negative or sputum-scarce pulmonary tuberculosis in bronchoalveolar lavage fluid." 07/01/2005 - "Since the introduction of rifampicin, it has been believed that pulmonary tuberculosis can be cured with medication alone. " 11/01/2000 - "To assess the efficacy of a daily, self-administered 8-month rifampicin-containing regimen for the treatment of pulmonary tuberculosis (TB) in human immunodeficiency virus (HIV) infected adults. " 11/01/2000 - "Efficacy of an unsupervised 8-month rifampicin-containing regimen for the treatment of pulmonary tuberculosis in HIV-infected adults. "
3.	VaccinesIBA 01/15/2002 - "Bacille Calmette-Guerin (BCG) is the world's most widely used vaccine, but there are concerns that it provides little protection against pulmonary tuberculosis of humans in countries that have a high prevalence of environmental mycobacteria. " 10/01/2020 - "Bacillus Calmette-Guérin (BCG) vaccination induces variable protection against pulmonary tuberculosis (TB), and a more effective TB vaccine is needed. " 01/01/2013 - "The failure of Mycobacterium bovis Bacille Calmette-Guérin to impart satisfactory protection against adult pulmonary tuberculosis has necessitated the development of more effective TB vaccines. " 09/01/2013 - "One-month Phase II trial was conducted in 43 sputum smear-positive patients with pulmonary tuberculosis randomized into treatment (n = 22) and placebo (n = 21) arms to investigate the safety and efficacy of an orally-administered therapeutic TB vaccine (V7) containing 10 μg of heat-killed Mycobacterium vaccae provided by Longcom company. " 01/01/2022 - "However, it shows only partial efficacy against pulmonary tuberculosis (TB) in adults, so new vaccines are urgently needed. "
4.	BCG Vaccine FDA Link 10/01/2016 - "The commonly used Bacillus Calmette-Guérin (BCG) vaccine only induces moderate T cell responses and is less effective in protecting against pulmonary tuberculosis (TB) in adults and ageing populations. " 01/01/2012 - "The Bacille-Calmette Guérin (BCG) vaccine does not provide consistent protection against adult pulmonary tuberculosis (TB) worldwide. " 07/15/2010 - "Mutations that arose in bacille Calmette-Guérin (BCG) daughter strains during decades of in vitro cultivation have long been suspected of reducing the efficacy of the BCG vaccine against pulmonary tuberculosis. " 02/01/2002 - "The efficacy of Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine against pulmonary tuberculosis (TB) varies enormously in different populations. " 10/01/2012 - "Clinical trials worldwide have proved the inadequacy of the BCG vaccine in preventing the manifestation of pulmonary tuberculosis in adults. "
5.	Streptomycin (Streptomycin Sulfate)FDA Link 07/01/1950 - "[Limits of the efficacy of PAS in primary pulmonary tuberculosis and indications for associated PAS-streptomycin treatment; research and considerations on 185 cases]." 01/01/2021 - "In this Series paper, we provide a historical perspective on clinical trial research by revisiting the 1948 streptomycin trial for pulmonary tuberculosis, which was the first documented randomised clinical trial in the English language, and we discuss its close connection with global health. " 01/01/2010 - "This paved the way for the first randomized control trial of streptomycin in pulmonary tuberculosis carried out in 1946 by MRC of the UK. " 04/01/2004 - "The 1948 report of the British Medical Research Council's randomized trial of streptomycin for pulmonary tuberculosis is widely regarded as marking the beginning of the modern history of controlled clinical trials. " 05/01/1957 - "[Studies on the clinical pictures of pulmonary tuberculosis patients and the bacteriostatic effects of tubercle bacillus in the resected specimens, with special reference to streptomycin-resistance. "
6.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2002 - "The use of endobronchial and intracavernous myramistine in combination with antituberculous agents to patients with destructive pulmonary tuberculosis caused by multidrug-resistant MBT strains reduced the latter's resistance to antibiotics, cured tubendobronchitis in most patients, created conditions for obliteration of the cavernous cavity. " 10/01/2016 - "The absence of a gold standard to determine when antibiotics induce a sterilizing cure has confounded the development of new approaches to treat pulmonary tuberculosis (PTB). " 07/01/1958 - "[Correlations between functional disturbances and radiological improvement in several cases of extensive pulmonary tuberculosis treated with antibiotics]." 01/01/1954 - "[Several cases of ulcerated pulmonary tuberculosis cured with antibiotics alone]." 06/01/2015 - "This study also confirms poorer prognoses for pulmonary tuberculosis sufferers hospitalized in sanatoria before antibiotics and reveals that a significant number of patients survived enough time to develop bone lesions."
7.	Pyrazinamide FDA LinkGeneric 12/01/2019 - "Safety of pyrazinamide-including regimen in late elderly patients with pulmonary tuberculosis: A prospective randomized open-label study." 09/01/2006 - "This study was designed to characterize the population pharmacokinetics of pyrazinamide in South African pulmonary tuberculosis patients, with special reference to interindividual and interoccasional variability (IIV and IOV, respectively). " 01/01/1990 - "[Clinical and laboratory studies in patients with pulmonary tuberculosis treated with pyrazinamide]." 01/01/2019 - "Serum pyrazinamide concentrations in patients with pulmonary tuberculosis." 01/01/2017 - "We found good penetration of pyrazinamide into lung tissue among patients with pulmonary tuberculosis with a variety of radiological lesion types. "
8.	Ethambutol (Myambutol)FDA LinkGeneric 01/31/1969 - "[Management of chronic pulmonary tuberculosis using ethambutol (6 months of treatment)]." 01/01/2019 - "Early discontinuation of ethambutol in pulmonary tuberculosis treatment based on results of the GenoType MTBDRplus assay: A prospective, multicenter, non-inferiority randomized trial in South Korea." 12/24/1983 - "In a controlled study of culture-positive advanced pulmonary tuberculosis we have compared treatment regimens with PZA in a dosage of less than 2 g and with ethambutol (EMB). " 01/01/1966 - "[Contribution to the study of respiratory function in subjects with pulmonary tuberculosis treated with ethambutol]." 05/01/2022 - "This case highlights that ethambutol toxicity is rare in cases of new onset pulmonary tuberculosis where ethambutol has been administered for only 2 months."
9.	Proteins (Proteins, Gene)FDA Link 01/01/1956 - "[Dynamics of sedimentation of erythrocytes and protein fractions of the blood in phases of fulmination and remission of pulmonary tuberculosis]." 09/01/2023 - "Therefore, the current study was designed to evaluate the utility of previously identified proteins, encoded by in vivo expressed mycobacterial transcripts in pulmonary tuberculosis, as diagnostic targets for a serodiagnostic assay. " 02/01/2019 - "In the present study we have assessed T cell immuno-phenotypes in BCG vaccinated healthy individuals and patients with active pulmonary tuberculosis in response to two latency associated DosR Regulon Proteins Rv2626c and Rv2032. " 01/01/2018 - "In this study, we wanted to examine the levels of neutrophil and eosinophil granular proteins in individuals with pulmonary tuberculosis (PTB) and to compare them with the levels in individuals with latent TB (LTB). " 01/01/2015 - "Our study employed two-dimensional gel electrophoresis and mass spectrometry to analyze the proteins associated with active pulmonary tuberculosis complicated with diabetes. "
10.	AcidsIBA 01/01/2003 - "Although mycobacterial culture positivity is the gold standard for the diagnosis, the initial approach to the diagnosis of pulmonary tuberculosis (PTbc) is the detection of acid-fast bacilli (AFB) in respiratory specimens as recommended by the World Health Organization. " 08/15/2019 - "The aim of this study was to determine the diagnostic accuracy of Xpert MTB/RIF in sputum smear-negative pulmonary tuberculosis using acid-fast bacilli (AFB) culture as the gold standard. " 10/15/2016 - "We collected sputum specimens before treatment from Gambians and Ugandans with pulmonary tuberculosis, revealed by positive results of acid-fast bacillus smears. " 09/01/2002 - "To evaluate the efficacy of three sputum acid-fast bacillus (AFB) smears to rule out pulmonary tuberculosis, sputum AFB smear and culture results were analyzed at two university-affiliated teaching hospitals. " 06/02/2023 - "The aim of this study was to compare metagenomic next-generation sequencing (mNGS) with other methods, including Xpert MTB/RIF, Mycobacterium tuberculosis (MTB) culture, and acid-fast bacillus (AFB) staining in the diagnosis of pulmonary tuberculosis (PTB) using bronchoalveolar lavage fluid (BALF). "

Therapies and Procedures

1.	Therapeutics 10/01/2009 - "Twenty-one patients were lost for follow-up (11%) and 76% of the smear-positive pulmonary tuberculosis therapies were declared successful but only 34% were declared cured with the WHO criteria. " 01/01/2015 - "Objective, reproducible quantification of the extent of abnormalities seen on a chest radiograph would improve the user-friendliness of a previously proposed severity scoring system for pulmonary tuberculosis and could be helpful in monitoring response to therapy, including in clinical trials. " 10/01/2022 - "Here, we present three cases with early RTL that occurred after completing pulmonary tuberculosis (TB) therapy with a cure, and that improved by early diagnosis and therapy. " 05/01/2018 - "She had been previously diagnosed with pulmonary tuberculosis elsewhere and prescribed antitubercular therapy; however, there was little improvement in her symptoms. " 01/01/2017 - "We updated a systematic review and metaanalysis to examine the efficacy of different intermittent dosing schedules in first-line pulmonary tuberculosis therapy. "
2.	Drug Therapy (Chemotherapy) 01/01/1966 - "Bacteriological response is generally considered the best criterion for assessing the efficacy of chemotherapy in patients with pulmonary tuberculosis. " 01/01/1990 - "Appropriate three-stage chemotherapy with the use of surgical interventions, if indicated permits one to achieve in the reformatory institutions of the Ministry of Home Affairs a high efficacy of treatment of ++newly-diagnosed pulmonary tuberculosis patients, which concurrently significantly decreases their epidemic danger for the general population when they are let free." 03/01/2002 - "To assess the efficacy of WHO-recommended standard short-course chemotherapy in newly detected pulmonary tuberculosis cases positive by smear or with extensive lung lesions suggestive of culture positivity, under project conditions. " 06/01/2004 - "Pulmonary resection in combination with chemotherapy appears to be an effective measure for the treatment of multi-drug resistant pulmonary tuberculosis. " 03/09/1984 - "Chemotherapy of pulmonary tuberculosis was effective for existing disease in all ages and prevented dissemination. "
3.	Immunotherapy 12/01/1990 - "Improved immunotherapy for pulmonary tuberculosis with Mycobacterium vaccae." 04/01/2000 - "Adjunctive immunotherapy with heat-killed Mycobacterium vaccae was studied in a randomized, placebo-controlled trial of 120 non-human immunodeficiency virus-infected adults with newly diagnosed pulmonary tuberculosis. " 07/10/1999 - "Immunotherapy with Mycobacterium vaccae in patients with newly diagnosed pulmonary tuberculosis: a randomised controlled trial. " 01/01/1997 - "In this study, 206 previously untreated patients with sputum culture positive pulmonary tuberculosis were randomized to receive an injection of killed Mycobacterium vaccae as immunotherapy, or of saline as placebo, after 1 month of a 6-month chemotherapeutic regime. " 03/01/1995 - "A study to assess the impact of immunotherapy with Mycobacterium vaccae on the treatment of pulmonary tuberculosis was conducted under existing conditions in Kano, a large city in Northern Nigeria. "
4.	Pneumonectomy (Lung Volume Reduction) 04/01/2017 - "We report the case of a female patient aged 53 years who benefited from a left pneumonectomy on pulmonary tuberculosis sequelae. " 06/01/1951 - "[Case of pulmonary tuberculosis cured by pneumonectomy]." 04/01/1995 - "[Long-term study of patients with sequelae of pulmonary tuberculosis after pneumonectomy--obstructive impairment and its causes]." 11/01/1971 - "[Radiological and physiological studies on overdistension of lung after pneumonectomy in patients with pulmonary tuberculosis]." 01/01/1968 - "[Studies on the results of pneumonectomy for pulmonary tuberculosis]."
5.	Retreatment 07/01/2013 - "This study evaluated the efficacy of retreatment of pulmonary tuberculosis (TB) with regard to treatment outcomes and antimicrobial susceptibility testing (ST) profiles. " 11/01/2003 - "Improved cure rates in pulmonary tuberculosis category II (retreatment) with mycobacterium w." 03/01/2017 - "The objective of this study was to investigate the relationship between NLR and pulmonary tuberculosis (PTB) retreatment. " 05/01/2010 - "The aim of the study was to determine drug sensitivity and DNA fingerprints of Mycobacterium tuberculosis strains from retreatment cases of pulmonary tuberculosis. " 01/01/2009 - "250 patients in need of retreatment for pulmonary tuberculosis were enrolled in the study. "